A system and/or method for diagnosing a neurologic condition. The system comprises a wearable head orientation sensor, a wearable eye imaging module, and a display with a visual target. The head orientation sensor is responsive to pitch or yaw head orientation information. The eye imaging module is configured for imaging a characteristic of the retina, sclera, cornea, limbus, or pupil to determine an eye position or eye movement. An electronic circuit in the system determines an ocular parameter measurement in response to the head orientation sensor and the eye imaging module. The neurologic condition is diagnosed in response to the ocular parameter measurement.

A system and method are provided for obtaining a pupil response profile for a subject. The method include: obtaining scan data as frames of a pupil response over time prior to, during and after exposure to a flash of a light source; locating a candidate pupil to be measured from the scan data; image processing the scan data to obtain a set of pupil candidate measurements to generate a graph of pupil measurements against time; filtering the graph to produce a final set of pupil measurements forming a pupil response profile. The method may also include: measuring profile parameters from the pupil response profile; and using the profile parameters to determine aspects of the pupil response.

A method for enhancing digital images during a microsurgery, e.g., an eye surgery, includes collecting digital images of target anatomy using a digital camera as the target anatomy is illuminated by warm white light. The method includes identifying, via a processor in communication with the digital camera, a predetermined stage of the microsurgery. Within the images, the processor digitally isolates a first pixel region, e.g., a pupil pixel region, from a second pixel region, e.g., an iris pixel region, and adjusts a characteristic of constituent pixels thereof. The method, possibly recorded as instructions in a computer-readable medium, may be used to enhance a red reflex at predetermined stages of an eye surgery. A system includes a lighting source for emitting warm white light having a color temperature of less than about 4000° K, the camera, and the processor.

A method for performing digital measurements by obtaining a first video stream of a user at a first distance to a camera; using an element appearing in the first video stream to generate a transformation factor to convert pixel distance in the first video stream to actual physical distance in the real world; using the transformation factor to obtain a first digital measurement in the first video stream; obtaining a second video stream at a second distance, larger than the first distance; using the first digital measurement and an angular measurement to an item appearing in the second video stream to determine a measurement of the second distance.

An ophthalmological image processing apparatus acquires a plurality of images of a subject eye photographed in a scanning-type imaging optical system, sets any one of the plurality of images as a template, sets corresponding points or corresponding regions between an image of the subject eye and the template at a plurality of positions of each of the image of the subject eye and the template, calculates a movement amount of each of the corresponding points or each of the corresponding regions, and corrects a distortion of the image of the subject eye with respect to the template based on the movement amount of each of the corresponding points or each of the corresponding regions.

The present disclosure relates to a method and a system for detecting a neurological disease and an eye gaze-pattern abnormality related to the neurological disease of a user. The method comprises displaying stimulus videos on a screen of an electronic device and simultaneously filming with a camera of the electronic device to generate a video of the user's face for each one of the stimulus videos, each one of the stimulus videos corresponding to a task. The method further comprises providing a machine learning model for gaze predictions, generating the gaze predictions for each video frame of the recorded video, and determining features for each task to detect the neurological disease using a pre-trained machine learning model.

The present invention relates to sedation assessment. In order to facilitate sedation depth monitoring in an autonomous imaging setting, it is proposed to use the imaging modality itself to measure the response to suitable reflexes in order to determine the depth of sedation wherein suitable reflexes include, but are not limited to, the pupil reflex, so-called superficial reflexes and the withdrawal reflexes. In one embodiment, the pupil reflex may be measured in an MRI system by repeated interleaving of dedicated iris MR imaging with the conventional scan protocol. In another embodiment, superficial reflexes in response to stroking of the skin may be measured. This may involve a dedicated actuator that may be closely integrated with the imaging modality, e.g. an MR receive coil applied to the patient. Alternatively, remote haptic systems may be used. The reflex is then acquired with a suitable diagnostic imaging method. In another embodiment, the withdrawal reflex in response to pain may be measured. This may involve an actuator that induces sudden stitching pain or very local temperature-induced pain and that is closely integrated with the imaging modality, e.g. a pinching device integrated with a patient support or an MR receive coil applied to the patient. The reflex is then acquired with a suitable diagnostic imaging method.

The present invention is directed to a medical imaging binocular indirect ophthalmoscope with onboard sensor array and computational processing unit, enabling simultaneous or time-delayed viewing and collaborative review of photographs or videos from an eye examination. The invention also claims a method for photographing and integrating information associated with the images, videos, or other data generated from the eye examination.

A reflectometry instrument includes a light source for emitting an illumination beam that illuminates the macula. A portion of the illumination beam is reflected from the macula and forms a detection beam. The detection beam is indicative of macular pigment in the macula. The instrument also includes a first mirror for reflecting the illumination beam toward the macula and for reflecting the detection beam from the macula. The instrument is configured so that the illumination beam and the detection beam remain separated between the macula and the first mirror.

A narrow angle illumination light source for an ophthalmic surgical laser system includes multiple light emitting diodes (LEDs), multiple corresponding ball lenses, multiple corresponding upper apertures located between the LEDs and the lenses (optional), and multiple corresponding lower apertures located below the lenses. The light passing through each upper aperture and corresponding lens forms a light cone having a defined divergence angle and cone axis angle; the light cone only illuminates the corneal and sclera of a docked eye without illuminating the patients nose and orbit. The lower apertures may have distinctive shapes to aid video focusing. The multiple LEDs are distributed uniformly in the circle, and may be divided into multiple independently controllable segments which allows directional illumination. The LEDs also have controllable brightness to allow images of darker and brighter illuminations to be taken in short succession.