Some aspects of the present disclosure relate a method for magnetic resonance imaging, which can include acquiring, by applying an imaging pulse sequence, magnetic resonance data associated with a region of interest of a subject. The imaging pulse sequence can include a plurality of RF pulses configured to generate a desired image contrast, and an outer-volume suppression (OVS) module to attenuate the signal outside the region of interest. The method can further include reconstructing, from the acquired magnetic resonance data, a plurality of reduced field of view (rFOV) magnetic resonance images corresponding to the region of interest.

Systems and methods can be used to provide an indication of heart function, such as an indication of mechanical function or hemodynamics of the heart, based on electrical data. For example, a method for assessing a function of the heart can include determining a time-based electrical characteristic for a plurality of points distributed across a spatial region of the heart. The plurality of points can be grouped into at least two subsets of points based on at least one of a spatial location for the plurality of points or the time-based electrical characteristics for the plurality of points. An indication of synchrony for the heart can be quantified based on relative analysis of the determined time-based electrical characteristic for each of the at least two subsets of points.

Systems and methods are provided for performing optical coherence tomography angiography for the rapid generation of en face images. According to one example embodiment, differential interferograms obtained using a spectral domain or swept source optical coherence tomography system are convolved with a Gabor filter, where the Gabor filter is computed according to an estimated surface depth of the tissue surface. The Gabot-convolved differential interferogram is processed to produce an en face image, without requiring the performing of a fast Fourier transform and k-space resampling. In another example embodiment, two interferograms are separately convolved with a Gabor filter, and the amplitudes of the Gabor-convolved interferograms are subtracted to generate a differential Gabor-convolved interferogram amplitude frame, which is then further processed to generate an en face image in the absence of performing a fast Fourier transform and k-space resampling. The example OCTA methods disclosed herein are shown to

An adaptive real-time radial k-space sampling trajectory (ARKS) can respond to a physiologic feedback signal to reduce motion effects and ensure sampling uniformity. In this adaptive k-space sampling strategy, the most recent signals from an ECG waveform can be continuously matched to the previous signal history, new radial k-space locations c were determined, and these MR signals combined using multi-shot or single-shot radial acquisition schemes. The disclosed methods allow for improved

Provided is a system and method of generating an aggregated stability map of one or more rotational sources associated with a heart rhythm disorder. In accordance therewith, a plurality of rotational area profile maps is accessed for a plurality of analysis intervals. Each of the rotational area profile maps includes rotation intensity values for a plurality of locations associated with rotation of the one or more rotational sources. Thereafter, an aggregated stability map is generated map based on the plurality of rotational area profile maps, wherein the aggregated stability map includes a plurality of locations. Each location includes a rotation intensity value based at least on a filter level of highest rotation intensity values for that location from corresponding locations of the plurality of rotational area profile maps.

A system and computer-implemented method for analysing or monitoring a subject, the method comprising: identifying one or more objects of interest that have been segmented from a first image comprising any of a baseline scan, a follow-up scan or a reference image of the subject; identifying predefined landmarks of the objects; determining reference morphometries pertaining to the objects by performing morphometrics on the objects by reference to the landmarks; selecting one or more regions of interest (ROIs) from the objects according to the reference morphometries, comprising identifying respective locations of the ROIs relative to the reference morphometries; performing a first analysis of the one or more ROIs; performing at least one corresponding second analysis of the one or more ROIs in respectively at least one second image comprising any other of a baseline scan, a follow-up scan or a reference image; and generating a comparison of one or more results of the first analysis and one or more corresponding results of the second analysis.

A photo detector can include: a light emitting device configured to emit light; a driving circuit configured to drive the light emitting device; a photo-electric conversion circuit configured to generate an optical current signal according to an optical signal; an isolation circuit configured to transmit the optical current signal in an isolated manner; an ambient light filter configured to filter a current component of the optical current signal corresponding to an ambient light, and to generate a clean optical current signal; a current amplification circuit configured to amplify the clean optical current signal, and to generate an amplified optical current signal; (vii) an analog-to-digital converter configured to convert the amplified optical current signal to a digital signal; and a control circuit configured to output an optical detection signal according to the digital signal.

A pair of new catheters designed to be deployed as a catheter system to allow a simultaneous acquisition of electrograms from widely dispersed electrodes in the left atrium, right atrium, and coronary sinus. The first catheter is the spiral globe catheter which has the primary shape of a spiral globe and has additional modifications to facilitate safe entry into the left atrium, to orient the primary axis of the spiral globe toward the mitral valve, and to maximize contact of electrodes to multiple areas of the left atrium. The second catheter is the right atrial and coronary sinus catheter (RA-CS catheter) which allows for electrogram acquisition from the length of the coronary sinus and dispersed areas of the right atrium. The catheter system is designed to provide adequate electrode sensor information so that panoramic mapping of the both atria and the coronary sinus may be performed.

Devices, methods, systems and procedures for localized, targeted treatment of angiogenic-based therapy in at least one region of interest in one or more layers of cardiac tissue. Various methods can include diagnosing a patient with ischemic heart disease or “at-risk” of manifesting ischemic heart disease, placing the patient into a specific angiogenic-based treatment therapy group, collecting image data, confirming image data and other diagnostic test results, developing a preoperative plan to target region of interest, inserting the catheter into a heart chamber, monitoring the distal end of the catheter tip within the heart on a visual display, contacting at least one layer of cardiac tissue, creating one or more channels in the heart tissue and/or administering the angiogenic-based therapy.

Systems and methods are described for the compositing together of model-linked vascular data from a plurality of sources, including at least one 2-D angiography image, for display in a frame of reference of the at least one angiography image. In some embodiments, a linking model comprises a data structure configured to link locations of angiographic images to corresponding elements of non-image vascular parameter data. The linking data structure is traversed to obtain a mapping to the frame of reference of one or more of the angiographic images.