An aspect of the present disclosure calculates a phase variance value indicating a degree of variance of a phase in a surrounding of each position in a biological tissue, based on phase values of excitation wave at respective positions in the biological tissue that acts in response to excitation caused by propagation of the excitation wave in the tissue, and generates an analysis map, based on a time series of at least part of the phase variance values at the respective positions. Since the phase variance value indicates the degree of variance of the phase in the surrounding, a position having a large degree of variance of the phase in the surrounding may be specified as a rotation center of rotating excitation wave.

Systems and methods are described for implementing a catheter model to estimate shape of a deformable catheter in a three-dimensional space. The catheter model includes two or more model segments that correspond to two or more segments of the deformable catheter. Each model segment includes a length and location of model electrode(s) and/or model magnetic sensor(s) corresponding electrodes and/or magnetic sensors of the deformable catheter. Variable shape parameter define a curvature of the segment. Varying the shape parameters generates a plurality of potential catheter shapes. In conjunction with generating the potential catheter shapes, impedance and/or magnetic responses (e.g., measured responses) are obtained for the physical electrodes and/or physical magnetic sensors of the deformable catheter. Using a selected one (e.g., most likely) of the potential catheter shapes and the measured responses, the shape parameters are updated and a catheter shape is generated and displayed.

Biomarkers and/or risk assessments identify patients having an increased risk of certain clinical disease states including, for example, CHD, type 2 diabetes, dementia, or all-cause death (ACD) using NMR signal to measure a level of “GlycA” in arbitrary units or in defined units (e.g., μmol/L) that can be determined using a defined single peak region of proton NMR spectra. The GlycA measurement can be used as an inflammation biomarker for clinical disease states. The NMR signal for GlycA can include a fitting region of signal between about 2.080 ppm and 1.845 ppm of the proton NMR spectra.

The invention provides various methods of identifying myocardial infarction (MI) patients who have microvascular obstruction (MO), persistent microvascular obstruction (PMO), reperfusion hemorrhage, iron deposition, chronic iron deposition, and/or fat infiltration/accumulation. The invention provides various methods of identifying myocardial infarction (MI) patients who are at risk of prolonged inflammation burden in heart, adverse cardiac remodeling, electrical abnormality, mechanical abnormality, malignant cardiac arrhythmia, ischemic heart failure, and/or sudden cardiac death. The invention also provides various methods of treating these MI patients with chelation drugs, anti-inflammatory drugs, fat-lowering drugs, cooling therapies, or device therapies, or their combinations.

The invention provides methods and systems for imaging.

An imaging steering apparatus includes sensors and an imaging processor configured for: acquiring, via multiple ones of the sensors and from a current position (322), and current orientation (324), an image of an object of interest; based on a model, segmenting the acquired image; and determining, based on a result of the segmenting, a target position (318), and target orientation (320), with the target position and/or target orientation differing correspondingly from the current position and/or current orientation. An electronic steering parameter effective toward improving the current field of view may be computed, and a user may be provided instructional feedback (144) in navigating an imaging probe toward the improving. A robot can be configured for, automatically and without need for user intervention, imparting force (142) to the probe to move it responsive to the determination.

Provided are a medical image processing device, a medical image processing method, a program, and a medical image display system that reduce the amount of movement of a line of sight in a case in which a medical image is observed. A first medical image of a subject is displayed. A second medical image including an anatomical feature structure closest to a designated position in the first medical image is acquired. The first medical image and the second medical image are registered. A region including the identified anatomical feature structure is cut out from the second medical image based on a registration result to generate a second partial region image. The second partial region image is displayed to be superimposed on the first medical image.

For three-dimensional segmentation from two-dimensional intracardiac echocardiography imaging, the three-dimension segmentation is output by a machine-learnt multi-task generator. The machine-learnt multi-task generator is trained from 3D information, such as a sparse ICE volume assembled from the 2D ICE images. The machine-learnt multi-task generator is trained to output both the 3D segmentation and a complete volume. The 3D segmentation may be used to project to 2D as an input with an ICE image to another network trained to output a 2D segmentation for the ICE image. Display of the 3D segmentation and/or 2D segmentation may guide ablation of tissue in the patient.

Provided herein is a catheter assembly including an imaging device for identifying an anatomical structure. The catheter assembly includes a patient cannula configured to be drawn along a catheter or guide wire; a transseptal puncture catheter at least partially enclosed within the patient cannula; and an imaging catheter. The imaging catheter includes a transducer configured to emit an energy beam capable of reflecting from an anatomical structure and to detect energy reflected from the structure. The catheter assembly also includes a transmitter for conveying a signal representative of the detected energy from the transducer to a signal processor for obtaining information about the structure. An imagining system and a method for identifying a predetermined transseptal puncture location on an atrial septum are also provided herein.

Systems and methods are provided for performing optical coherence tomography angiography for the rapid generation of en face images. According to one example embodiment, differential interferograms obtained using a spectral domain or swept source optical coherence tomography system are convolved with a Gabor filter, where the Gabor filter is computed according to an estimated surface depth of the tissue surface. The Gabor-convolved differential interferogram is processed to produce an en face image, without requiring the performing of a fast Fourier transform and k-space resampling. In another example embodiment, two interferograms are separately convolved with a Gabor filter, and the amplitudes of the Gabor-convolved interferograms are subtracted to generate a differential Gabor-convolved interferogram amplitude frame, which is then further processed to generate an en face image in the absence of performing a fast Fourier transform and k-space resampling. The example OCTA methods disclosed herein are shown to achieve faster data processing speeds compared to conventional OCTA algorithms.