Pressure sensing guidewires and methods for making and using pressure sensing guidewires are disclosed. An example pressure sensing guidewire may include a tubular member having a proximal region and a housing region. An optical fiber may be disposed within the tubular member and extend to the housing region. The optical fiber may have a distal end region with a cavity formed therein. A polymeric member disposed within the cavity. A reflective surface disposed along the polymeric member.

A catheter system for optical coherence tomography includes an elongate catheter body, an optical fiber in the elongate catheter body, and an anamorphic lens assembly coupled with a distal end of the optical fiber. The optical fiber and the lens assembly are together configured to provide a common path for optical radiation reflected from a target and from a reference interface between the distal end of the optical fiber and the lens assembly.

The present invention provides compositions and methods for imaging tumor resections.

A surgical system includes a detector, comprising an array of pixels configured to detect light reflected by a surgical instrument and generate a first signal comprising a first dataset representative of a visible image of the surgical instrument. The surgical system also includes a processor configured to receive the first signal, generate a modified image of the surgical instrument that includes a control panel. The control panel includes one or more control elements representative of one or more operating parameters of the surgical instrument. The processor is further configured to receive an input to the control panel from a user, the input being effective to change one of the operating parameters. The processor is also configured to generate a command signal based on the input to change the one of the operating parameters.

A sterile sheath and methods for enclosing a confocal endomicroscopy (CEM) scanner probe with the sterile sheath are provided. The scanner probe includes a probe shaft, a probe tip, a probe body, and a probe umbilical. The sterile sheath for enclosing the CEM scanner probe includes a sheath tube configured to receive the probe shaft and has a distal tube end, a proximal tube end, a sheath tip mounted at the distal tube end of the sheath tube, and a sheath socket configured to receive the probe body. The sheath socket has a distal socket end and a proximal socket end. The proximal tube end of the sheath tube is fixed to the sheath socket at the distal socket end. The sterile sheath further includes a sheath lock ring and a sheath drape mounted on the sheath socket at the proximal socket end with the sheath lock ring.

In part, the invention relates to a probe suitable for use with image data collection system. The probe, in one embodiment, includes an optical transceiver, such as a beam director, and an acoustic transceiver such as an ultrasound transducer. The optical transceiver is in optical communication with an optical fiber in optical communication with a beam director configured to transmit light and receive scattered light from a sample such as a wall of a blood vessel. The acoustic transceiver includes an ultrasound device or subsystem such as a piezoelectric element configured to generate acoustic waves and receive reflected acoustic waves from the sample.

A digital topographic model of the luminal surface is generated by projecting an optical pattern on the luminal surface from the first location within the lumen. At least a portion of the projected pattern is detected from a second location within the lumen which is based apart from the first location. The dimensions of the luminal wall can be measured by triangulation in order to produce the digital topographic model of the body lumen.

A pulse signal corresponding to rotation of an imaging core is input, and a repetition frequency of the input pulse signal is converted in accordance with the number of radially-aligned lines of an ultrasound tomographic image. Based on the pulse signal of which the repetition frequency has been converted, a drive signal for an ultrasound transceiver is generated to obtain an ultrasound tomographic image with the number of lines. A valid pulse is determined in accordance with the number of lines from the pulse signal of which the repetition frequency has been converted. A signal having a pulse train selected, based on the valid pulse from a pulse signal representing a cycle of a light source of light for interfering with the light from an optical transceiver is generated as a pulse signal representing a timing of sampling of an optical coherence signal for generating an optical tomographic image.

A method of modeling lungs of a patient includes acquiring computed tomography data of a patient's lungs, storing a software application within a memory associated with a computer, the computer having a processor configured to execute the software application, executing the software application to differentiate tissue located within the patient's lung using the acquired CT data, generate a 3-D model of the patient's lungs based on the acquired CT data and the differentiated tissue, apply a material property to each tissue of the differentiated tissue within the generated 3-D model, generate a mesh of the 3-D model of the patient's lungs, calculate a displacement of the patient's lungs in a collapsed state based on the material property applied to the differentiated tissue and the generated mesh of the generated 3-D model, and display a collapsed lung model of the patient's lungs based on the calculated displacement of the patient's lungs.

A device and method is provided for a suction tool combined with an optical probe. A suction device is provided having a tip with a hollow tubular body, a plurality of optical fibers embedded in the tip and a concentric ring attached to the tip, wherein the ring end has an inner beveled reflective surface opposing the optical fibers. A method is provided for optically measuring tissue in a medical procedure comprising suctioning a tissue using a suction device, sending optical signals along optical fibers through the suction device; directing the signals from the optical fibers onto the tissue using a beveled surface; receiving optical signals from the tissue in optical fibers via the beveled reflective surface; measuring the received optical signals in a spectrometer or detector; and releasing, resecting or ablating the tissue through the suction device.