This invention is a wearable device or system for optical analysis of breast tissue which be embodied in a “smart bra” or an insert which is placed into the cup of a conventional bra. This device or system has light emitters which transmit light into breast tissue and light receivers which receive the light after it has been transmitted through the breast tissue. It also has expandable chambers which gently compress a breast to reduce light diffusion and improve optical scanning of breast tissue.

A method and apparatus for dual mode imaging uses an ultrasonic detection device, a diffuse optical tomography (DOT) detection device for imaging a breast. The DOT detection device is configured to detect changes of tissue blood oxygen. A host machine in communication with the ultrasonic detection device and the DOT detection device is used for imaging the breast by simultaneously generating functional images and structural information images of the breast based on the imaging.

Described herein are methods and systems for analyzing a sample by applying time resolved laser induced fluorescence spectroscopy to the sample to measure lifetime time decay profile data relating to the sample, and applying multivariate analysis to process the data so as to classify a sample as, for example, normal or abnormal. The sample may be cells, fluid or tissue from any organ. The sample may be in vitro or in vivo. The data may be obtained in situ or in vitro.

A breast imaging apparatus includes a radiation source that irradiates a breast of a subject with radiation, a radiation detector that detects the radiation transmitted through the breast to output a radiographic image, and an ultraviolet light source that performs irradiation of ultraviolet light. The ultraviolet light source irradiates an imaging table, a face guard, a pressing plate, and the like with the ultraviolet light in a case where a turn-on command signal input from an operator through an input device is input.

A portable two-mode probe intended to be applied against a biological tissue to be examined, the probe comprising: an ultrasonic transducer (34, 63), configured to emit ultrasonic waves into the tissue and to receive ultrasonic waves reflected by the tissue, the transducer extending along a transverse axis; at least two optodes (32, 60, 62a, 62b) placed on either side of the transverse axis, such that the transducer extends between the two optodes; each optode comprising a casing (52, 61), the casing containing: a light emitter (31), configured to emit a light wave toward the tissue; and/or an optical detector (32), configured to detect a light wave scattered by the tissue; the optodes being arranged such that at least one light emitter and at least one optical detector are placed on either side of the transducer;
at least one optical detector having a detection area (53, 63a, 63b) formed from a semiconductor and connected to a circuit board (54).

A mammography device is disclosed. The mammography device includes a container configured to surround the breast and a plurality of optical fibers attached to be directed inward in the container and configured to perform radiation and detection of light. The container has a base member having an opening, a plurality of annular members continuously disposed to come in communication with the opening, and a bottom member disposed inside the annular member spaced the farthest distance from the base member. The annular members and the bottom member are configured to relatively displace the adjacent annular member on the side of the base member or the base member in a communication direction. Some of the plurality of optical fibers is attached to the plurality of annular members.

Electromagnetic energy is deposited into a volume, an acoustic return signal from energy deposited in the volume is measured, and a parametric map that estimates values of at least one parameter as spatially represented in the volume is computed. A reference level of a region of interest is determined, and upper and lower color map limits are specified, with at least one of them being determined in relation to the reference level. The parametric map is then rendered in the palette of a color map by mapping the estimated values of the parametric map onto the color map according to the color map limits. Two wavelengths of energy can be applied to the volume, and the parametric map computation can be adapted by applying an implicit or explicit model of, or theoretical basis for, distribution of electromagnetic energy fluence within the volume pertaining to the two wavelengths. The actual electromagnetic energy fluence caused by each wavelength has a propensity, due to variability within the volume, to differ from the modeled or theoretical electromagnetic energy fluence.

The present invention relates to the use of a NIR fluorescent probe comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety in the fluorescence- guided surgery of pathologic regions and to an optical imaging method that comprises using this fluorescent probe for the identification and demarcation of tumor margins during the surgical resection.

Systems, methods, and computer program products are disclosed that can receive temperature data from at least one temperature sensor over a period of time. At least one metric of the temperature data can be calculated, which may utilize the temperature data from a particular sensor over the period of time and may be indicative of variability in the temperature data. A tissue assessment can be determined by utilizing a classifier with at least one feature input to the classifier, the feature(s) being determined from the metric(s).

Systems and methods for spectral analysis of a tissue mass using an instrument, an optical probe, and a Monte Carlo algorithm or a diffusion algorithm are provided. According to one method, an instrument is inserted into a tissue mass. A fiber optic probe is applied via the instrument into the tissue mass. Turbid spectral data of the tissue mass is measured using the fiber probe. The turbid spectral data is converted to absorption, scattering, and/or intrinsic fluorescence spectral data via a Monte Carlo algorithm or diffusion algorithm. Biomarker concentrations in the tissue mass are quantified using the absorption, scattering, and/or intrinsic fluorescence spectral data.