A method of forming a probability map is disclosed. According to one embodiment, a method may include: (1) obtaining multiple measures of multiple imaging parameters for every stop of a moving window on an image, wherein two neighboring ones of the stops of the moving window are partially overlapped with each other; (2) obtaining first probabilities of an event for the stops of the moving window by matching the measures of the imaging parameters to a classifier; and (3) obtaining second probabilities of the event for multiple voxels of a probability map based on information associated with the first probabilities.

Systems, method, and devices useful in medical procedures, such as, e.g., aesthetic and/or reconstructive surgeries, are described. The system may be at imaging system that includes a database and a computer system configured to create, modify, and/or display three-dimensional images created from digital image data of an anatomical region of a subject. The digital image data maybe obtained with an imaging device such as a scanner.

A diffuse-optical-spectroscopy system and method for scanning human tissue is provided. The system includes: (a) a handheld probe operable to emit electromagnetic radiation at one or more wavelengths corresponding to absorption associated with one or more human-tissue constituents, respectively, the handheld probe being operable to detect received electromagnetic radiation at each of the wavelengths; and (b) a processor operable to produce, in response to the received electromagnetic radiation, one or more cross-sectional images of the human tissue respectively associated with the wavelengths.

The handheld probe includes first and second sources for emitting the electromagnetic radiation and one or more sensors for detecting the received electromagnetic radiation. The sensors are aligned along a first axis and face in an outward direction. The first and second sources are aligned along the first axis, face in the outward direction, and are disposed on either side of the sensors.

The present disclosure relates to method for predicting location and depth of abnormal tissue in breast tissue by prediction system. The prediction system predicts location based on 2D thermal image generated based on temperature values and intermediate temperature values. The intermediate temperature values are estimated using triangular and rectangular patterns formed on pre-defined model of breast, thermal conductivity of breast tissue, 2D coordinates on one of triangular and rectangular patterns and temperature values at steady state of breast tissue. The depth is predicted based on 3D thermal image of breast tissue generated using temperature values and intermediate temperature values and error parameter. The intermediate temperature values are estimated based on one of tetrahedral and hexahedral patterns formed on predefined model of breast, density value, thermal conductivity of tissue, blood perfusion rate, specific heat capacity of blood, 3D coordinates, arterial temperature and metabolic heat generation value in normal and abnormal tissue.

A method and system for determining the presence of a mass of cancerous cells in vivo within a tissue body is provided. The method includes: a) performing an examination of the tissue body using a diagnostic method operable to determine the presence of a suspect tissue mass, and determining a location of the same; b) administering a solution containing “RR-CTEs”, the RR-CTEs configured to target and bind with cancerous cells; c) interrogating the tissue body with a beam of light, wherein the RR-CTEs are configured to produce Raman scattered light upon impingement; d) collecting the Raman scattered light; e) processing the collected Raman scattered light to determine a presence or an absence of the a Raman signature; and f) comparing the determined location of the suspect tissue mass with the determined location of the mass of cancerous cells to determine the presence of the mass of cancerous cells.

An aspect of some embodiments of the present invention relates to a method for determining one or more characteristics of a region of interest. The method includes providing stimulation for exciting the region of interest for a first selected time period; monitoring mechanical response of the region of interest for at least a second time period after said first time period; processing data indicative of said mechanical response, and determining data on one or more measures of motion of the region of interest; utilizing data on one or more measures of motion for yielding at least one damping parameter indicative of damping of the mechanical response of the region of interest, and determining at least one characteristic of the region of interest in accordance with at least one damping parameter.

A diffuse-optical-spectroscopy system and method for scanning human tissue. The system includes: (a) a handheld probe operable to emit electromagnetic radiation at one or more wavelengths corresponding to absorption associated with one or more human-tissue constituents, respectively, the handheld probe being operable to detect received electromagnetic radiation at each of the wavelengths; and (b) a processor operable to produce, in response to the received electromagnetic radiation, one or more cross-sectional images of the human tissue respectively associated with the wavelengths. The handheld probe includes first and second sources for emitting the electromagnetic radiation and one or more sensors for detecting the received electromagnetic radiation. The sensors are aligned along a first axis and face in an outward direction. The first and second sources are aligned along the first axis, face in the outward direction, and are disposed on either side of the sensors.

An optoacoustic probe for optoacoustic imaging of a volume, the optoacoustic probe having a distal end operable to contact the volume and a proximal end. The optoacoustic probe includes at least one primary light source and an auxiliary light source that is configured to generate auxiliary light carried through an optical window to a volume. A detection device is configured to detect signals generated from the auxiliary light or primary light reflecting from the volume or the optical window. A microcontroller including one or more processors is also provided, that receives the signals generated from the auxiliary light reflecting from the volume from the detection device, determines contact between the volume and the optoacoustic probe based on the auxiliary light reflecting from the volume, and prevents the at least one primary light source from generating light until the optoacoustic probe is contacting the volume.

The present disclosure relates to method for predicting location and depth of abnormal tissue in breast tissue by prediction system. The prediction system predicts location based on 2D thermal image generated based on temperature values and intermediate temperature values. The intermediate temperature values are estimated using triangular and rectangular patterns formed on pre-defined model of breast, thermal conductivity of breast tissue, 2D coordinates on one of triangular and rectangular patterns and temperature values at steady state of breast tissue. The depth is predicted based on 3D thermal image of breast tissue generated using temperature values and intermediate temperature values and error parameter. The intermediate temperature values are estimated based on one of tetrahedral and hexahedral patterns formed on predefined model of breast, density value, thermal conductivity of tissue, blood perfusion rate, specific heat capacity of blood, 3D coordinates, arterial temperature and metabolic heat generation value in normal and abnormal tissue.

An optoacoustic probe for optoacoustic imaging of a volume, the optoacoustic probe having a distal end operable to contact the volume and a proximal end. The optoacoustic probe includes at least one primary light source and an auxiliary light source that is configured to generate auxiliary light carried through an optical window to a volume. A detection device is configured to detect signals generated from the auxiliary light or primary light reflecting from the volume or the optical window. A microcontroller including one or more processors is also provided, that receives the signals generated from the auxiliary light reflecting from the volume from the detection device, determines contact between the volume and the optoacoustic probe based on the auxiliary light reflecting from the volume, and prevents the at least one primary light source from generating light until the optoacoustic probe is contacting the volume.