A system includes a housing having a first end portion and a second end portion, a SPECT detector disposed in the housing, a first support, a first coupling coupled to the first end portion of the housing and to the first support, a second support defining a bore, and a second coupling coupled to the second end portion of the housing and to the second support, where the housing is disposed between the first support and the second support.

Embodiments access an image of a region of interest (ROI) demonstrating cancerous pathology; extract radiomic features from the ROI; define a radiomic feature expression scene based on the ROI and radiomic features; generate a cluster map by superpixel clustering the expression scene; generate an expression map by repartitioning the cluster map into expression levels; compute a textural and spatial phenotypes for the expression map based on the expression levels; construct a radiomic spatial textural (RADISTAT) descriptor by concatenating the textural and spatial phenotypes; provide the RADISTAT descriptor to a machine learning classifier; receive, from the machine learning classifier, a first probability that the ROI is a responder or non-responder, or a second probability that the ROI will experience long-term survival or short-term survival, based, at least in part, on the RADISTAT descriptor; and generate a classification of the ROI as a responder or non-responder, or long-term survivor or short-term survivor.

Detector designs and systems for enhanced radiographic imaging with integrated detector systems incorporate one or more of Compton and nuclear medicine imaging, PET imaging and x-ray CT imaging capabilities. Detector designs employ one or more layers of detector modules comprised of edge-on or face-on detectors or a combination of edge-on and face-on detectors which may employ gas, scintillator, semiconductor, low temperature (such as Ge and superconductor) and structured detectors. Detectors may implement tracking capabilities and may operate in a non-coincidence or coincidence detection mode.

A radiation detector for combined detection of low-energy radiation quanta and high-energy radiation quanta, the radiation detector (8) having a multi-layered structure, comprising: a rear scintillator layer (5) configured to emit a burst of scintillation photons responsive to a high-energy radiation quantum being absorbed by the rear scintillator layer (5); a rear photosensor layer (6) attached to a back side of the rear scintillator layer (5), said rear photosensor layer (6) configured to detect scintillation photons generated in the rear scintillator layer (5); a front scintillator layer (3) arranged in front of the rear scintillator layer (5) opposite the rear photosensor layer (6), said front scintillator layer (3) configured to emit a burst of scintillation photons responsive to a low-energy radiation quantumbeing absorbed by the front scintillator layer (3); and a front photosensor layer (2) attached to a front side of the front scintillator layer (3) opposite the rear scintillator layer (5), said front photosensor layer (2) configured to detect scintillation photons generated in the front scintillator layer (3), wherein the high-energy radiation quantum is a gamma ray and the low-energy radiation quantum is an X-ray.

A system for low-count quantitative single-photon emission computed tomography (LC-QSPECT) is provided. The system is programmed to a) store a computer tomography (CT) scan of a subject being examining including a plurality of defined volumes of interest (VOIs) of the subject being examined; b) model a system matrix based on the stored CT, wherein the model describes the probability that photons emitted from each of the defined VOIs are detected in different projection bins, wherein a plurality of projection bins are defined around the subject and the defined VOIs; c) adjust the model with analysis of stray-radiation noise around the subject; d) detect, by the one or more sensors, one or more photons being emitted by an alpha-particle-emitting isotope; and e) execute the adjusted model with the one or more detected photons as inputs to determine a source VOI of the detected photons.

A medical image diagnostic device according to an embodiment includes a first collector, a second collector, and an image generator. The first collector collects data from a first region of a subject through a first detector. The second collector collects data from a second region of the subject that is different from the first region through a second detector. The image generator generates a first diagnostic image from the data collected by the first collector and generates a second diagnostic image from the data collected by the second collector.

Detector designs and systems for enhanced radiographic imaging with integrated detector systems incorporate one or more of Compton and nuclear medicine imaging, PET imaging and x-ray CT imaging capabilities. Detector designs employ one or more layers of detector modules comprised of edge-on or face-on detectors or a combination of edge-on and face-on detectors which may employ gas, scintillator, semiconductor, low temperature (such as Ge and superconductor) and structured detectors. Detectors may implement tracking capabilities and may operate in a non-coincidence or coincidence detection mode.

A dual mode radiation detector comprising an x-ray detector layer to convert incident x-ray radiation into x-ray electrical data, said x-ray detector forming an incident face of said dual mode radiation detector, a collimator disposed below the x-ray detector layer, and a gamma photon detector layer disposed below the collimator to convert incident gamma photons into gamma photon electrical data.

Detector module designs for radiographic imaging include first and second layers of scintillator rods or pixel arrays oriented in first and second directions. The first and second directions are transversely oriented to define a light sharing region between the first and second layers. Encoding features may be disposed in, on or between the first and second layers, and configured to modulate propagation of optical signals therealong or therebetween.

A mechanical linkage system of PET and CT/MRI and a linkage scanning method thereof are disclosed. According to an example of the disclosure, the mechanical linkage system includes a PET host, a CT/MRI host, a scanning bed, and a moving system. The PET host includes a PET detector installed in a PET detector fixing plate and configured to form a positron emission computed tomography image. The CT/MRI host has a larger aperture than the PET detector. A front end of the PET host and a front end of the CT/MRI host are oppositely disposed. The scanning bed is located to an end of the CT/MRI host. The moving system is connected with at least one of the PET host or the CT/MRI host and configured to move the PET detector into or out of a scanning field of view of the CT/MRI host.