A portable biometric wrist device having an optical sensor and including at least one light source and at least one light detector installed onto a circuit board, a casing having at least one aperture for said at least one light source and at least one aperture for said at least one light detector, wherein each of said at least one light source and at least one light detector are optically isolated from each other inside said casing with a sealing plate between said casing and said circuit board, said sealing plate having at least one aperture for said at least one light source and at least one aperture for at said least one light detector. The present invention also provides a method for manufacturing said portable biometric wrist device.

According to one embodiment, a power-efficient, low noise photoplethysmographic (PPG) sensor module is provided herein comprising at least one light emitting diode (LED) and at least one photodetector. The LED is generally configured for emitting light, and is positioned on the PPG sensor module for transmitting the emitted light into biological tissue. The photodetector is generally configured for detecting a portion of the light that is transmitted by the LED into the biological tissue and reflected back to the photodetector. The photodetector is an elongated photodetector having a longer dimension that is at least 1.5 times larger than a shorter dimension of the elongated photodetector. By positioning the elongated photodetector on the PPG sensor module, such that the longer dimension is facing towards the first LED, the elongated photodetector is configured to collect substantially more of the reflected light, thereby increasing the signal-to-noise ratio of the detected signal.

Various examples are directed to sleep management devices and methods of operating the same. A sleep management device may comprise a display. The sleep management device may be programmed to detect a first wake event and select a first wake routine associated with the first wake event. The sleep management device may execute the first wake routine at least in part by modulating an output of the display for a first duration. The sleep management device may also detect a second wake event different than the first wake event and second wake routine associated with the second wake event. The sleep management device may execute the second wake routine at least in part by modulating the output of the display for a second duration longer than the first duration.

Various devices, systems and methods for performing targeted sleep tracking are presented herein. Multiple digital radar data streams from multiple antennas may be received. A direction optimization process may be performed to determine a first weighting and a second weighting. The first weighting may be applied to a first digital radar data stream. The second weighting may be applied to a second digital radar data stream. The weighted first digital radar data stream and the weighted second digital radar data stream may be combined to create a first directionally-targeted radar data stream. A sleep analysis can be performed based on the first directionally-targeted radar data stream. Sleep data may be output for a user based on the performed sleep analysis.

A pulse wave analyzing apparatus comprises an acquiring section (11) which acquires a pulse wave that is non-invasively measured, and an analyzer (12) which calculates data on the frequency axis by using the pulse wave, and which obtains the index value of the respiratory-induced variation based on the calculated data on the frequency axis.

The invention relates to a method for measuring the human heartbeat rate, comprising the steps of: 1) obtaining a video of the measured subject; 2) parsing the video into a series of image frames; 3) arranging the multiple generated image frames in sequential order; 4) detecting the position of the region of the face in each image; 5) obtaining the facial fluctuation frequency of the measured object according to the change of the position of the face region in the image frame system.

An extended wavelength defined as a length of a signal waveform corresponding to a locus traced by a detected signal of an inertial sensor in a time domain per unit time is calculated, and an activity state of an observed person observed by the inertial sensor is determined based on the extended wavelength.

This invention provides methods for mapping and ablating renal nerves to treat disease caused by systemic renal nerve hyperactivity, e.g. hypertension, heart failure, renal failure and diabetes. Also provided are catheters for performing the mapping and ablating functions.

Angiopoietin-like protein (ANGPTL)3/8 complexes and antibodies are disclosed, where the antibodies bind to and thereby neutralize ANGPTL3/8 complexes. Pharmaceutical compositions also are disclosed that include one or more anti-ANGPTL3/8 complex antibodies herein in a pharmaceutically acceptable carrier. Methods of making and using the same also are disclosed, especially for increase lipoprotein lipase activity and lowering triglycerides. In this manner, the compounds and compositions may be used in treating lipid metabolism-related and glucose metabolism-related diseases and disorders.

A system, device and method for automatically and remotely acquiring sensor data from a wearable patch mounted on a patient. An example device implemented as a wearable patch includes a sensor assembly comprising a plurality of sensors configured to detect a corresponding plurality of sensory modalities and generate electrical signals representing the sensory modalities. A signal converter receives the electrical signals from the plurality of sensors and converts the signals to sensor data signals comprising a data representation of at least one of the electrical signals. A communications interface communicates the sensor data signals to a sensor data processing system.