A system for in-vivo monitoring of intracranial pressure is provided. The system includes a probe and a controller. The probe includes optical emitters and optical detectors. The optical detectors detect light emitted by the optical emitters generate signals representative of the detected light. The controller includes memory and processor. The controller connects to the probe to energize the optical emitters and receiving signals from the optical detectors. The system may include modelling, extraction, and pressure prediction modules. The modelling module can relate intracranial pressure to features of an optical signal representative of a degree to which light input into a subject's skull is absorbed by the subject's brain. The extraction module can extract signal features from a signal derived from the optical signals output by the detectors. The pressure prediction module can input the signal features into the modelling module and output an indication of intracranial pressure.

Provided herein are systems, methods, and media capable of determining estimated force applied on a target tissue region to enable tactile feedback during interaction with said target tissue region.

Provided is an apparatus configured to estimate bio-information, the apparatus including a pulse wave sensor including a plurality of channels disposed in an isotropic shape, a force sensor configured to measure a force applied by an object to the pulse wave sensor, and a processor configured to detect a center of gravity based on pressure, applied by the object, in a space formed by the plurality of channels based on pulse wave signals measured by each of the plurality of channels included in the pulse wave sensor, provide a user with guide information with respect to contact of the object to the pulse wave sensor based on the detected center of gravity, and estimate bio-information based on the pulse wave signals and the force which are measured based on the guide information.

An optical measuring apparatus includes first and second light-emitting elements that emit light and a controller. Upon detection of the presence of a body by light emitted from the first light-emitting element, the controller performs control so that the second light-emitting element will emit light with an amount for measuring the body.

A method and a device for label-free all-optical neural regulation and imaging are provided. The method stimulates a neural activity through an infrared laser pulse, and acquires an optical scattered signal caused by the neural activity by optical coherence tomography (OCT) to realize label-free all-optical neural regulation and imaging. The method specifically includes: aiming an infrared laser at a target brain region, injecting a certain time series of laser pulses, synchronously scanning and imaging the target brain region by OCT, analyzing a relative change of an OCT scattered signal before and after laser stimulation, and acquiring a brain function signal based on OCT to realize synchronous neural regulation and imaging. The method and the device enable synchronous neural regulation and imaging without causing crosstalk between the regulation and imaging channels, and without the need for injection of a contrast agent or viral transfection.

A measurement apparatus includes a light source, a sensor including light detection cells including a first light detection cell and a second light detection cell, and an electronic circuit. The circuit causes the light source to emit a light pulse, causes the first light detection cell to detect a reflected light pulse from a target in an exposure period including at least part of a period from when an intensity of the reflected light pulse starts increasing to when it starts falling and generate a first signal, causes the second light detection cell to detect the reflected light pulse in an exposure period including at least part of a trailing period from when the intensity of the reflected light pulse starts falling to when it stops falling and generate a second signal. The circuit generates, based on the first and second signals, data representing states of the target.

Systems and methods for providing a user characteristic to a service provider for a virtual conference with a user are provided. In particular, a computing device may collect raw media data associated with the user during the virtual conference between the user and the service provider. During the virtual conference, the computing device may perform a first processing of the raw media data to extract intermediate user data, wherein the intermediate user data comprises one or more of a physiological signal and a behavioral signal associated the user. The computing device may further transform the raw media data into transformed media data and transmit the transformed media data with the intermediate user data to a server for second processing of the intermediate user data.

This fluid evaluation device is provided with an irradiation unit for irradiating a fluid with light, a light reception unit for receiving scattered light from the fluid and outputting a light reception signal, and an estimation unit for estimating at least one from among flow rate and density by mapping input points, which are on a first plane defined by flow rate and frequency and are expressed by light amount information indicating the amount of scattered light included in the light reception signal and frequency information indicating a frequency for a beat signal resulting from the Doppler shifting of the light included in the light reception signal, onto a second plane defined by fluid flow rate and fluid density.

A sleep assessment system includes a blood flow measurement unit and a assessment unit. The blood flow measurement unit acquires first information related to the blood flow of the user. The assessment unit determines the sleep stage of the user based on the first biological information.

Offset illumination using multiple emitters in a fluorescence imaging system is described. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The emitter comprises a first emitter and a second emitter for emitting different wavelengths of electromagnetic radiation. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises one or more of a hyperspectral emission, a fluorescence emission, and/or a laser mapping pattern.