A system for monitoring hemodynamic status of a patient can include a transducer, an adapter and one or more monitor devices. The adapter may be in communication with the transducer and the one or more monitor devices. The adapter can be configured to receive and process data from the transducer such as unprocessed physiological data. The adapter can be configured to transmit data to the monitor device(s) such as processed and/or unprocessed physiological data. The adapter can be configured to generate, and transmit to the monitor devices(s), user interface data for rendering interactive graphical user interfaces to display information such as physiological information relating to a hemodynamic status of the patient. The adapter can be configured to receive and process, from the monitor device(s) user commands or instructions to control an operation of the system or its components.

The present disclosure relates to a method for quantitation of microcirculation in a subject, in which a functional capillary ratio is calculated from a plurality of motion images of target factors over time in a first blood stream passing through the capillaries of the subject, and to an apparatus for measuring microcirculation in a subject. The present disclosure also relates to a method for providing information on microcirculatory disorder in a subject, in which a dynamic element in target factors is analyzed from a plurality of motion images of the target factors over time in a second blood stream passing through the capillaries of the subject, and an apparatus for diagnosis of microcirculatory disorder in a subject. The present disclosure also relates to a composition for prevention or treatment of lung injury, which contains an inhibitor against the expression or activity of macrophage-1 antigen (Mac-1) in neutrophils within pulmonary capillaries and alleviates microcirculatory disorder in the lung, a screening method, and a method for providing information for diagnosis of lung injury and disorder. The composition according to an embodiment of the present disclosure can inhibit the expression or activity of macrophage-1 antigen in neutrophils within pulmonary capillaries to allow erythrocyteserythrocytes to smoothly pass through the pulmonary capillary, whereby gas exchange is increased in a subject suffering from pulmonary microcirculatory disorder and, thus, the microcirculatory disorder in the lung can be alleviated. Thus, the composition exhibits excellent effect as a composition for prevention or treatment of lung injury.

The present disclosure relates to a method for quantitation of microcirculation in a subject, in which a functional capillary ratio is calculated from a plurality of motion images of target factors over time in a first blood stream passing through the capillaries of the subject, and to an apparatus for measuring microcirculation in a subject. The present disclosure also relates to a method for providing information on microcirculatory disorder in a subject, in which a dynamic element in target factors is analyzed from a plurality of motion images of the target factors over time in a second blood stream passing through the capillaries of the subject, and an apparatus for diagnosis of microcirculatory disorder in a subject. The present disclosure also relates to a composition for prevention or treatment of lung injury, which contains an inhibitor against the expression or activity of macrophage-1 antigen (Mac-1) in neutrophils within pulmonary capillaries and alleviates microcirculatory disorder in the lung, a screening method, and a method for providing information for diagnosis of lung injury and disorder. The composition according to an embodiment of the present disclosure can inhibit the expression or activity of macrophage-1 antigen in neutrophils within pulmonary capillaries to allow erythrocyteserythrocytes to smoothly pass through the pulmonary capillary, whereby gas exchange is increased in a subject suffering from pulmonary microcirculatory disorder and, thus, the microcirculatory disorder in the lung can be alleviated. Thus, the composition exhibits excellent effect as a composition for prevention or treatment of lung injury.

There is described a method for calculating a patient-specific hemodynamic parameter. The method comprises measuring at least one pressure measurement in an artery using an intravascular pressure measurement device, and taking at least one medical image of the artery from a medical imaging instrument, the at least one medical image of the artery being synchronous with the at least one pressure measurement. Both the pressure measurement and the medical image are fed to a computing system to calculate a flow from the at least one medical image, to calculate parameters of the artery from at least two artery pressure drops and corresponding flow components, and based on the flow and the parameters of the artery, to calculate a patient-specific hemodynamic parameter or a plurality thereof.

There is described a method for calculating a patient-specific hemodynamic parameter. The method comprises measuring at least one pressure measurement in an artery using an intravascular pressure measurement device, and taking at least one medical image of the artery from a medical imaging instrument, the at least one medical image of the artery being synchronous with the at least one pressure measurement. Both the pressure measurement and the medical image are fed to a computing system to calculate a flow from the at least one medical image, to calculate parameters of the artery from at least two artery pressure drops and corresponding flow components, and based on the flow and the parameters of the artery, to calculate a patient-specific hemodynamic parameter or a plurality thereof.

Provided are a method and apparatus for adjusting blood flow velocity in maximum hyperemia state based on index for microcirculatory resistance. The method comprises: acquiring an index for microcirculatory resistance iFMR during a diastolic phase according to a blood flow velocity v, an aortic pressure waveform, and an physiological parameter (S100); making an adjustment parameter r equal to 1 if the index for microcirculatory resistance iFMR during the diastolic phase is less than K; making the adjustment parameter r satisfy a formula r=1−(iFMR−K)/100 if the index for microcirculatory resistance iFMR during the diastolic phase is greater than or equal to K, wherein K is a positive number less than 100 (S200); acquiring a corrected blood flow velocity in a maximum hyperemia state according to a product of the adjustment parameter and a blood flow velocity in the maximum hyperemia state (S300).

Methods and systems are provided for estimating velocity of blood, flowing along a blood vessel at a blood flow direction, based on measurements made using a medical implement that resided in a portion of the blood vessel and comprised a first electrode and a second electrode. One of the disclosed methods include: accessing voltage measurements measured at the first and second electrodes when a bolus of a fluid went through the portion of the blood vessel at the blood flow direction; wherein the voltage measurements were made at the first and the second electrodes; estimating a time that took the bolus to go from the first electrode to the second electrode based on the accessed voltage measurements; and estimating the velocity of the blood based on the estimated time and a distance known to exist along the medical implement between the first and second electrodes.

A system and method are provided for determining vascular velocity using non-invasively acquired medical images. The method includes reconstructing CT angiography (CTA) data into a plurality of images of the subject by producing a composite image using the CTA data corresponding to a set of the plurality of view angles, backprojecting each view angle in the CTA data and weighting a value backprojected into at image pixel by an attenuation value of a corresponding pixel in the composite image, and summing backprojected values for each image pixel to produce a CT image of the subject. The method also includes determining a flow direction or a velocity of flow within a vessel, calculating, using the flow direction or velocity, a pressure in the vessel, and generating a quantitative map of the subject indicating the flow direction, velocity, or pressure in the vessel against an image of the subject including the vessel.

Hyperspectral, fluorescence, and laser mapping imaging with a minimal area image sensor are disclosed. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation, wherein the pixel array comprises active pixels and optical black pixels. The system includes a black clamp circuit providing offset control for data generated by the pixel array. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises one or more of: electromagnetic radiation having a wavelength from about 513 nm to about 545 nm; electromagnetic radiation having a wavelength from about 565 nm to about 585 nm; electromagnetic radiation having a wavelength from about 900 nm to about 1000 nm; an excitation wavelength of electromagnetic radiation that causes a reagent to fluoresce; or a laser mapping pattern.

Hyperspectral, fluorescence, and laser mapping imaging with a minimal area image sensor are disclosed. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation, wherein the pixel array comprises active pixels and optical black pixels. The system includes a black clamp circuit providing offset control for data generated by the pixel array. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises one or more of: electromagnetic radiation having a wavelength from about 513 nm to about 545 nm; electromagnetic radiation having a wavelength from about 565 nm to about 585 nm; electromagnetic radiation having a wavelength from about 900 nm to about 1000 nm; an excitation wavelength of electromagnetic radiation that causes a reagent to fluoresce; or a laser mapping pattern.