The present disclosure provides methods and systems for flight velocimetry employing at least one bleaching laser, at least one detection laser, at least one dichroic mirror, an objective, a detection system, and a nano stage to bleach a dye to form a bleached blot in a flow pathway.

A sensor includes a light emitting element, a photodetector element for receiving light emitted by the light emitting element, and a circuit board having the light emitting element and the photodetector element mounted thereon. A light emitting surface of the light emitting element is facing the circuit board which is provided with a light-transmitting portion for transmitting the light emitted by the light emitting element.

An apparatus and method of assessing a narrowing in a fluid filled tube having a fluid flow pressure wave having a backward-originating pressure component and a forward-originating pressure component without taking a flow velocity measurement, comprising: taking pressure measurements in the tube; separating the pressure components into the backward-originating pressure component and the forward-originating pressure component; identifying a time window when the differential of flow velocity (dU) is minimal or absent; and deriving the backward and forward pressure components for pressure measurements taken in at least the time window.

An apparatus and method of assessing a narrowing in a fluid filled tube having a fluid flow pressure wave having a backward-originating pressure component and a forward-originating pressure component without taking a flow velocity measurement, comprising: taking pressure measurements in the tube; separating the pressure components into the backward-originating pressure component and the forward-originating pressure component; identifying a time window when the differential of flow velocity (dU) is minimal or absent; and deriving the backward and forward pressure components for pressure measurements taken in at least the time window.

The present disclosure is directed to methods and systems for fusing Phase Contrast Angiography (PCA) with anatomic images to create a perforator PCA (pPCA) data set. In the pPCA) method, vascular and anatomic information may be provided by different MRI sequences. A four-point acquisition scheme may be used for 3D PCA acquisition of vascular images. Anatomical MRI images are acquired and may be enhanced with image post-processing techniques. The vascular and anatomical images may be combined with image fusion to create a high resolution map of abdominal wall vasculature. This high resolution map visualizes not only the size and location of the DIEP perforators, but also their relationship with surrounding tissue, and the blood flow velocity within them. As such, the fused pPCA image has substantially higher SNR and CNR than CTA image of the same slice thickness.

The present disclosure is directed to methods and systems for fusing Phase Contrast Angiography (PCA) with anatomic images to create a perforator PCA (pPCA) data set. In the pPCA) method, vascular and anatomic information may be provided by different MRI sequences. A four-point acquisition scheme may be used for 3D PCA acquisition of vascular images. Anatomical MRI images are acquired and may be enhanced with image post-processing techniques. The vascular and anatomical images may be combined with image fusion to create a high resolution map of abdominal wall vasculature. This high resolution map visualizes not only the size and location of the DIEP perforators, but also their relationship with surrounding tissue, and the blood flow velocity within them. As such, the fused pPCA image has substantially higher SNR and CNR than CTA image of the same slice thickness.

Ruptured Abdominal Aortic Aneurysms (AAA) cause a large number of deaths annually. Ruptures occur even in people who are already diagnosed with AAA and are being monitored. The reason is that the interval between tests is too long because of the need to visit a pathological facility with imaging equipment. It is preferable to estimate the progress of AAA frequently, once detected, in a non-invasive manner, preferably at the subject's home, without the need for the subject to visit a pathological facility. A device is disclosed for detecting a state of a vascular pathology of a subject, comprising a sensor signal unit (103) for providing a signal representative of a blood volume in a body part of a subject, a comparator (107) for comparing the sensor signal with a reference signal, and a user interface (109) for conveying a result based on the comparison to a user of the device.

Ruptured Abdominal Aortic Aneurysms (AAA) cause a large number of deaths annually. Ruptures occur even in people who are already diagnosed with AAA and are being monitored. The reason is that the interval between tests is too long because of the need to visit a pathological facility with imaging equipment. It is preferable to estimate the progress of AAA frequently, once detected, in a non-invasive manner, preferably at the subject's home, without the need for the subject to visit a pathological facility. A device is disclosed for detecting a state of a vascular pathology of a subject, comprising a sensor signal unit (103) for providing a signal representative of a blood volume in a body part of a subject, a comparator (107) for comparing the sensor signal with a reference signal, and a user interface (109) for conveying a result based on the comparison to a user of the device.

An integrated sensing system for characterizing blood flow in a subject includes a light source assembly including a light source configured to emit light of a particular wavelength. The integrated sensing system includes an integrated circuit electrically connected to the light source assembly. The integrated circuit includes a light detector assembly including multiple light detectors configured to detect light of the particular wavelength; and a correlator configured to determining a delay between optical signals detected by respective light detectors of the light detector assembly.

A system and method prevents and diagnoses deep vein thrombosis in a body limb by providing a pressure sleeve having a plurality of individually fillable cells, the pressure sleeve being configurable to be placed around a body limb. A source fills each fillable cell individually, and a pressure sensor measures a pressure in a fillable cell. A controller establishes a fill sequence of each individually fillable cell and a fill time for each individually fillable cell. The controller causes a first individually fillable cell of the pressure sleeve to be filled to a predetermined pressure and causes the pressure of first individually fillable cell of the pressure sleeve to be measured while a second individually fillable cell of the pressure sleeve is filled. The controller determines a presence of deep vein thrombosis in a body limb having the pressure sleeve therearound based upon a measured pressure change in the first individually fillable cell of the pressure sleeve.