To provide a blood flow sensor in which a fluctuation of measurement results is suppressed during measurement of the blood flow volume. A probe portion is provided with a sensor portion which has a laser diode generating laser light, a photodiode receiving light, and a sensor housing having a contact surface contacting a subject and which irradiates a subject with the laser light generated by the laser diode through the contact surface, receives reflected light from the subject in the photodiode, and outputs a signal relating to the received light amount, a holding portion holding the sensor housing so as to be movable in an up-and-down direction crossing the contact surface, and a coil spring absorbing and transmitting external force applied to the holding portion to the sensor portion.

Systems and methods are provided for extracting hemodynamic information, optionally employing portable electronic devices with optional User Interface (UI) features for system implementation. The systems and methods may be employed for acquiring hemodynamic signals and associated electrophysiological data and/or analyzing the former or both in combination to yield useful physiological indicia or results. Such hardware and software is advantageously used for non-invasively monitoring cardiac health.

An optical sensor probe in which one end of optical fibers, of which the other end is connected to a light source or a Doppler measurement device, is linearly supported and arranged in a section of a buckling length L, a movement of the optical fibers in an optical axis direction is restricted at a fiber fixing point on an optical fiber-proximal side in the section of the buckling length L, the optical fibers are protrusively arranged through a restriction hole on an optical fiber-distal side in the section of the buckling length L, and the optical fibers are supported so as to be allowed to move only in the optical axis direction through the restriction hole. A measurement method is capable of measuring a blood flow rate, blood viscosity, or a vascular elastic modulus of the measurement target by measuring a Doppler shift of scattered light from the measurement target due to light emitted from the light source.

Disclosed herein are in vivo non-invasive methods and devices for the measurement of the hemodynamic parameters, such as such as blood pressure, stroke volume, cardiac output, performance of the aortic and mistral heart valves, arterial blood velocity profile, blood viscosity and the blood flow induced arterial wall shear stress, hypertensive/hypotensive and vasodilation/vasocontraction state and aging status of a subject, and the mechanical anelastic in vivo properties of the arterial blood vessels. An exemplary method requires obtaining the peripheral pulse volume waveform (PVW), the peripheral pulse pressure waveform (PPW), and the peripheral pulse velocity waveform (PUW) from the same artery; calculating the time phase shift between the PPW and PVW, and the plot of pulse pressure versus pulse volume; and determining the blood pressures and power law components of the anelastic model from the waveforms PPW and PVW, the cardiac output and heart valves performances from the waveforms PPW and PUW, and the anelastic in vivo properties of the descending, thoracic and abdominal aorta. The disclosed methods and devices can be used to diagnose and treat cardiovascular disease in a subject in need thereof.

Disclosed herein are in vivo non-invasive methods and devices for the measurement of the hemodynamic parameters, such as such as blood pressure, stroke volume, cardiac output, performance of the aortic and mistral heart valves, arterial blood velocity profile, blood viscosity and the blood flow induced arterial wall shear stress, hypertensive/hypotensive and vasodilation/vasocontraction state and aging status of a subject, and the mechanical anelastic in vivo properties of the arterial blood vessels. An exemplary method requires obtaining the peripheral pulse volume waveform (PVW), the peripheral pulse pressure waveform (PPW), and the peripheral pulse velocity waveform (PUW) from the same artery; calculating the time phase shift between the PPW and PVW, and the plot of pulse pressure versus pulse volume; and determining the blood pressures and power law components of the anelastic model from the waveforms PPW and PVW, the cardiac output and heart valves performances from the waveforms PPW and PUW, and the anelastic in vivo properties of the descending, thoracic and abdominal aorta. The disclosed methods and devices can be used to diagnose and treat cardiovascular disease in a subject in need thereof.

The blood flow analysis apparatus includes an acquisition unit and an extractor. The acquisition unit is configured to acquire blood flow information representing time-course changes in a blood flow velocity of a single retinal artery or retinal vein. The extractor is configured to extract one or more parameters corresponding to change in the blood flow velocity from the blood flow information.

System and apparatus for measuring biopotential and implementation thereof. A device for mitigating electromagnetic interference (EMI) thereby increasing signal-to-noise ratio is disclosed. Specifically, the present disclosure relates to an elegant, novel circuit for measuring a plurality of biopotentials in useful in a variety of medical applications. This allows for robust, portable, low-power, higher S/N devices which have historically required a much bigger footprint.

A stethoscope includes a housing that has a first surface and a second surface. The first surface defines a first groove on a first side of the housing and a second groove on a second side of the housing. A photoplethysmogram sensor assembly is operably coupled to the housing and is configured to obtain and push data to a controller. The photoplethysmogram sensor assembly includes a first optical sensor disposed in the first groove and a second optical sensor disposed in the second groove. Each of the first optical sensor and the second optical sensor includes an emitter and a detector. A phonocardiogram sensor is coupled to the second surface of the housing and is configured to obtain and push data to the controller.

Among the various aspects of the present disclosure is the provision of systems and methods of velocity-matched ultrasonic tagging in photoacoustic flowgraphy.

Among the various aspects of the present disclosure is the provision of systems and methods of velocity-matched ultrasonic tagging in photoacoustic flowgraphy.