A method and apparatus to non-invasively measure instantaneous blood pressure using pulse wave velocity are disclosed. A measurement component is affixed to a patient proximate to a blood vessel. One or more sensors, such as an ultrasound sensor, is included in the measurement component. The measurement component substantially simultaneously measures the pulse wave velocity of the vessel and the instantaneous blood velocity within the vessel. The measurement component computes the instantaneous blood pressure of the vessel using, for example, the water hammer equation. The one or more sensors may be contained in a disposable patch or collocated with another sensor, such as a patient-monitor sensor, or the like.

A method and apparatus to non-invasively measure instantaneous blood pressure using pulse wave velocity are disclosed. A measurement component is affixed to a patient proximate to a blood vessel. One or more sensors, such as an ultrasound sensor, is included in the measurement component. The measurement component substantially simultaneously measures the pulse wave velocity of the vessel and the instantaneous blood velocity within the vessel. The measurement component computes the instantaneous blood pressure of the vessel using, for example, the water hammer equation. The one or more sensors may be contained in a disposable patch or collocated with another sensor, such as a patient-monitor sensor, or the like.

A method for estimating a measure of cardiovascular health of a subject (102) comprises: receiving (302) an electrocardiogram, ECG, signal (202); receiving (304) an artery signal (210) representative of pressure pulse wave propagation at a location in an artery; determining (306) a fiducial point in time based on the ECG signal (202) providing an indication of onset of isovolumetric contraction; determining (308) a pre-systolic pressure pulse arrival point in time (212) based on the artery signal (210) to correspond to the onset of the isovolumetric contraction being reflected in the artery signal (210), determining (310) a time period between the onset of the isovolumetric contraction and the pre-systolic pressure pulse arrival point in time, said time period representing a vascular transit time; and determining (312) a pulse wave velocity of the subject (102) based on a physical distance between an aortic valve and the location in the artery and on the vascular transit time.

A method for estimating a measure of cardiovascular health of a subject (102) comprises: receiving (302) an electrocardiogram, ECG, signal (202); receiving (304) an artery signal (210) representative of pressure pulse wave propagation at a location in an artery; determining (306) a fiducial point in time based on the ECG signal (202) providing an indication of onset of isovolumetric contraction; determining (308) a pre-systolic pressure pulse arrival point in time (212) based on the artery signal (210) to correspond to the onset of the isovolumetric contraction being reflected in the artery signal (210), determining (310) a time period between the onset of the isovolumetric contraction and the pre-systolic pressure pulse arrival point in time, said time period representing a vascular transit time; and determining (312) a pulse wave velocity of the subject (102) based on a physical distance between an aortic valve and the location in the artery and on the vascular transit time.

The invention provides a system and a method for calculating a pulse wave velocity based on a plurality of intravascular ultrasonic pulses directed along a vessel. For each ultrasonic pulse, a plurality of echoes is received from a plurality of distances along the vessel. A first ultrasound Doppler signal is received from a first distance from the pulse origin and a second ultrasound Doppler signal from a second distance from the pulse origin. A first and second flow velocity metric is obtained based on the first and second ultrasound Doppler signal, respectively. The pulse wave velocity is calculated based on the time delay, which is based on the first flow velocity metric and the second flow velocity metric.

Computer-implemented methods and systems are provided for quantitative hemodynamic flow analysis, which involves retrieving patient specific image data. A 3D reconstruction of a vessel of interest can be created from the patient specific image data. Geometric information can be extracted from the 3D reconstruction. A lesion position can be determined. Patient specific data can be obtained. Hemodynamic results can be calculated based on the geometric information, the lesion position and the patient specific data.

The present disclosure provides methods and systems for flight velocimetry employing at least one bleaching laser, at least one detection laser, at least one dichroic mirror, an objective, a detection system, and a nano stage to bleach a dye to form a bleached blot in a flow pathway.

The present disclosure provides methods and systems for flight velocimetry employing at least one bleaching laser, at least one detection laser, at least one dichroic mirror, an objective, a detection system, and a nano stage to bleach a dye to form a bleached blot in a flow pathway.

A micro impulse radar (MIR) system includes art MIR transceiver circuit configured to transmit, towards a subject, at least one transmitted radar signal, and receive at least one radar return signal. The system includes a control circuit configured to generate a control signal defining a radar signal parameter of the at least one transmitted radar signal, provide the control signal to the MIR transceiver circuit to cause the MIR transceiver circuit to transmit the at least one transmitted signal based on the radar signal parameter, and determine, based on the at least one radar return signal, a physiological parameter of the subject.

A micro impulse radar (MIR) system includes art MIR transceiver circuit configured to transmit, towards a subject, at least one transmitted radar signal, and receive at least one radar return signal. The system includes a control circuit configured to generate a control signal defining a radar signal parameter of the at least one transmitted radar signal, provide the control signal to the MIR transceiver circuit to cause the MIR transceiver circuit to transmit the at least one transmitted signal based on the radar signal parameter, and determine, based on the at least one radar return signal, a physiological parameter of the subject.