In part, the disclosure relates to computer-based methods, devices, and systems suitable for performing intravascular data analysis and measurement of various types of data such as pressure and flow data. The disclosure relates to probes and methods suitable for determining an event in a cardiac cycle such as flow threshold such as a peak flow, a fraction thereof, other intravascular parameters or a point in time during which peak flow or a change in one of the perimeters occurs. An exemplary probe includes one or more of a pressure sensor, a resistor, a flow sensor and can be used to generate diagnostic data based upon measured intravascular and other parameters. In part, the disclosure relates to methods and systems suitable for determining a coronary flow reserve value in response to one or more of intravascular pressure and flow data or data otherwise correlated therewith.

In part, the disclosure relates to computer-based methods, devices, and systems suitable for performing intravascular data analysis and measurement of various types of data such as pressure and flow data. The disclosure relates to probes and methods suitable for determining an event in a cardiac cycle such as flow threshold such as a peak flow, a fraction thereof, other intravascular parameters or a point in time during which peak flow or a change in one of the perimeters occurs. An exemplary probe includes one or more of a pressure sensor, a resistor, a flow sensor and can be used to generate diagnostic data based upon measured intravascular and other parameters. In part, the disclosure relates to methods and systems suitable for determining a coronary flow reserve value in response to one or more of intravascular pressure and flow data or data otherwise correlated therewith.

The invention provides a ghrelin molecule for use in the treatment and/or prophylaxis of Acute Heart Failure (AHF) in an individual, as well as corresponding methods and uses. The invention further provides associated compositions and kits of parts, for use in the treatment and/or prophylaxis of AHF in an individual.

This word representation device comprises a storage unit and a word representation generation unit. With respect to the streamline structures constituting flow patterns, the storage unit stores the correspondence between each streamline structure and the characters thereof. The word representation generation unit is provided with a root determination means, a tree representation configuration means, and a COT representation generation means. The root determination means determines a root for a given flow pattern. The tree representation configuration means configures a tree representation for the given flow pattern by repeatedly executing a process of extracting the streamline structure of the flow pattern, adding characters to the streamline structure, and deleting the extracted streamline structure, until the root is reached. The COT representation generation means converts the tree representation configured by the tree representation configuration means to a COT representation and generates a word representation of a given flow pattern. The flow constituting the flow pattern includes a flow generated by moving physical boundaries.

This word representation device comprises a storage unit and a word representation generation unit. With respect to the streamline structures constituting flow patterns, the storage unit stores the correspondence between each streamline structure and the characters thereof. The word representation generation unit is provided with a root determination means, a tree representation configuration means, and a COT representation generation means. The root determination means determines a root for a given flow pattern. The tree representation configuration means configures a tree representation for the given flow pattern by repeatedly executing a process of extracting the streamline structure of the flow pattern, adding characters to the streamline structure, and deleting the extracted streamline structure, until the root is reached. The COT representation generation means converts the tree representation configured by the tree representation configuration means to a COT representation and generates a word representation of a given flow pattern. The flow constituting the flow pattern includes a flow generated by moving physical boundaries.

The invention relates to a system for challenging the pericardial space, to provide an indication of the risk of cardiac tamponade in a patient, as well as methods for diagnosis of, and determination of the extent of, a tamponade, and treating a patient in whom there is a detected cardiac tamponade.

The invention relates to a system for challenging the pericardial space, to provide an indication of the risk of cardiac tamponade in a patient, as well as methods for diagnosis of, and determination of the extent of, a tamponade, and treating a patient in whom there is a detected cardiac tamponade.

Medical devices are provided, comprising a medical device and a sensor.

Medical devices are provided, comprising a medical device and a sensor.

Coaptation assist device for repairing cardiac valves and associated systems and methods are disclosed herein. A coaptation assist device configured in accordance with embodiments of the present technology can include, for example, a fixation member configured to press against cardiac tissue proximate to a native valve annulus, and a stationary coaptation structure extending away from the fixation member. The coaptation structure can include an anterior surface configured to coapt with a first native leaflet during systole and a posterior surface configured to displace at least a portion of a second native leaflet. The device also includes at least one sensor configured to detect parameters associated with at least one of cardiac function and device functionality. The sensors can be pressure sensors configured to detect left atrial pressure and/or left ventricular pressure.