Catheters, systems, and related methods for optimized for mapping, minimizing, and treating cardiac fibrillation in a patient, including an array of at least one stacked electrode pair, each electrode pair including a first electrode and a second electrode, wherein each electrode pair is configured to be orthogonal to a surface of a cardiac tissue substrate, wherein each first electrode is in contact with the surface to record a first signal, and wherein each second electrode is separated from the first electrode by a distance which enables the second electrode to record a second signal, wherein the catheter is configured to obtain one or more measurements from at least a first signal and a second signal in response to electrical activity in the cardiac tissue substrate indicative of a number of electrical circuit cores and distribution of the electrical circuit cores for a duration across the cardiac tissue substrate.

A method (94) for aligning a cardiac model can include receiving (95) an initial position signal from three position sensors (17, 39, 40) disposed along a distal end of a coronary sinus catheter (13) positioned in a coronary sinus (41) of a heart (10). The method (94) can include receiving (96) a subsequent position signal from the three position sensors (17, 39, 40). The method (94) can include determining (97) a positional change vector based on a change in position between an initial position associated with the initial position signal and a subsequent position associated with the subsequent position signal. The method (94) can include shifting (98) a point of interest associated with a cardiac model, using the positional change vector. The method (94) can include dynamically aligning (100) the cardiac model based on an updated position of the three position sensors (17, 39, 40).

Various systems and methods for controlling an ultrasonic surgical instrument according to the location of tissue grasped within an end effector are disclosed. A control circuit can be configured to apply varying power levels, via a generator, to an ultrasonic transducer driving an ultrasonic electromechanical system to oscillate an ultrasonic blade. Further, the control circuit can measure impedances of the ultrasonic transducer corresponding to the varying power levels and determine a location of tissue positioned within the end effector according to a difference between the impedances of the ultrasonic transducer relative to a threshold.

Embodiments of the present disclosure include a medical device, comprising an elongate shaft extending along a shaft longitudinal axis and comprising a shaft proximal portion and a shaft distal portion. A navigational assembly is connected to the shaft distal portion and extends along the shaft longitudinal axis. The navigational assembly includes a navigational electrode positioning feature and a magnetic position sensor positioning feature.

A sensor (220) for a body monitoring system (1), having analyte-measuring microneedles (210) that extend parallel to a main direction (Z) from a substrate (242) and define a working plane (Pt), wherein the sensor (220) has at least one conductivity electrode (600) with a metallic track (602), the end of the metallic track extending along the main direction (Z) to a position strictly between the substrate (242) and the working plane (Pt).

An on-body sensor system (30) comprises at least two skin interface units (32, 34) for coupling signals into and out of the body, with one of the units being for placement at a known location. One unit applies electrical signals to the body and the other senses them at a remote location. By analyzing the sensed signals using a set of pre-determined body-transmission parameters, a position of one of the skin interface units can be determined. This allows accurate placement of one or the units, for instance to allow more accurate monitoring of physiological parameters using the unit. The body transmission parameters can change over time, whereas once the interface units are put in position, their position is stable. Hence the system also includes functionality to re-calibrate the transmission parameters using at least one known stable set of initial positions of the interface units. The re-calibration comprises a process of re-calculating the parameters based on the known positions. These can then be stored and used for future determinations of the position of the one of the skin interface units having a moveable location, for instance in the case that it is re-positioned or replaced.

Devices and systems for navigation and positioning a central venous catheter within a patient. In an exemplary embodiment of a system of the present disclosure, the system comprises a first pole and a second pole, the first pole and the second pole configured to generate an electric field within a mammalian body sufficient to obtain a plurality of field measurements therein, and an elongated body configured for at least partial insertion into a blood vessel of the mammalian body and advancement through a vasculature, said advancement dependent upon the plurality of field measurements indicative of one or more locations of a portion of the elongated body within the vasculature. In at least one embodiment, the elongated body is configured as a stylet.

A method and system for determining a location of a treatment element relative to an anatomical feature and for estimating contact between the treatment element and the anatomical feature in the context of a navigation system. The system may include a medical device including at least one treatment element and at least one navigation electrode and a navigation system in communication with the one or more navigation electrodes, the navigation system including a processing unit. The processing unit may be programmed to determine a plurality of points that define a surface geometry of the at least one treatment element, calculate a distance between each of the points and a closest point on the anatomical feature, and estimate the likelihood of contact between the points.

Arterial system navigation methods and devices and systems to perform the same. In an exemplary embodiment of a method of the present disclosure, the method comprises the steps of inserting at least part of an impedance device into an artery of a patient, the artery selected from the group consisting of a femoral artery and a radial artery, obtaining at least one conductance measurement while navigating a distal end of the impedance device through an arterial vasculature of the patient until the distal end is at or near a left ventricle, and performing at least one medical procedure at a location within the arterial vasculature.

A method includes receiving (i) a plurality of electrocardiogram (ECG) signals acquired by a mapping catheter at a plurality of locations on a surface of a heart of a patient, (ii) a reference ECG signal from a reference catheter positioned at a nominal location in a coronary sinus (CS) of the patient, and (iii) position signals indicative of a position of the reference catheter in the CS. An electrophysiological (EP) map of at least part of the heart is calculated by time-referencing the ECG signals relative to the reference ECG signal. Based on the position signals, a displacement of the reference catheter from the nominal location in the CS, which distorts the time-referencing, is estimated. The distortion in the EP map is mitigated using the estimated displacement.