The present disclosure describes a system for metabolic monitoring comprising: collecting exhaled gas from nasal airways of a subject; a mixing chamber for receiving a portion of the exhaled gas; a plurality of sensors for outputting signals related to gas parameters related to inhaled gas and exhaled gas during one or more breaths; and processors configured to determine a flow rate of gas in the interface appliance; determine pressure changes near the mouth of the subject to detect mouth breathing of the subject; determine concentration measurements of O2 and CO2 of the portion of the exhaled gas in the mixing chamber, and discard concentration measurements corresponding to mouth breathing; determine a rate of oxygen consumption VO2 and a carbon dioxide production VCO2 of the subject based on the determined flow rate, the CO2 concentration, and the determined O2 concentration.

A method for inducing a hibernation-like state and a device for the same is described. The method is a chemical and physical method for reducing, in a subject, a theoretical set-point temperature of a body temperature and/or a feedback gain of heat production, or for inducing a hibernation-like state in the subject, the method including applying an excitatory stimulus to pyroglutamylated RFamide peptide (QRFP)-producing neurons. A device used to implement the method is also described.

Disclosed herein is a method and apparatus for determining a parameter of a gas present in an exhaled gas flow comprising: providing an apparatus gas flow with a time-varying parameter to a patient, measuring a parameter of the gas present in a composite gas outflow from the patient, and determining the parameter of the gas present in the exhaled gas flow using the measured parameter of the gas present in the composite gas outflow and the time-varying parameter.

Resuscitation and ventilation monitoring devices are provided. A device includes an inlet in fluid communication with airflows exchanged with lungs of a patient and an airflow meter for measuring characteristics of the airflows. A user may provide a controller with patient information, e.g., height, weight, gender, or age, via a measurement selector, enabling the controller to determine acceptable ranges of measured airflow characteristics. The device may determine a current mode of ventilation and associated ventilator settings based on the measured airflow characteristics. The device may also identify and filter out artifacts present in the ventilation signal, and determine whether a respiratory failure phenotype is present in the ventilation. If the current mode of ventilation and associated ventilator settings fall outside an acceptable range, the ventilation is classified as off-target and the controller may cause a sensory alarm to alert the user. The device may suggest a corrective action based on the type of off-target ventilation detected. The device may also continuously analyze ventilation to determine changes in lung compliance over time and to identify pathological changes over time. The device may work within a network of devices and user interfaces via wired or wireless communication, and is not restricted to or dependent on the type of ventilatory device with which a patient is being supported.

A conventional flow tube for a metabolic cart is usually a straight length of pipe whose inner diameter is fixed by the respiratory burden imposed by the flow tube on the user, with a smaller diameter imposing a higher respiratory burden. The ratio of the straight flow tube's length to diameter is fixed by fluid dynamics, so increasing the flow tube's diameter causes the flow tube's length to increase. As the flow tube gets longer, it exerts more torque on the user's neck and jaw, creating discomfort. Reducing the flow tube's length causes an undesired increase in the respiratory burden but increasing the flow tube's diameter to reduce the respiratory burden makes the flow tube less comfortable, making the flow tube unconformable, hard to breathe through, or both. Bending the flow tube, e.g., in an L shape, makes it possible to increase the flow tube's propagation length without increasing the flow tube's lever arm length.

Mandibular advancement devices (MAD) are disclosed comprising an upper splint, a lower splint, and at least one sensor, wherein the sensor measures a biological or biophysical aspect of a patient. Methods of using the devices are also disclosed.

A nasal device is provided to measure an aspect of gas flowing through a user's nose. The nasal device includes a body having a first interior side and a second, opposing interior side. The body forms a lumen between the first interior side and the second interior side through which the gas flows into and out of the user's nose. The nasal device further includes an emitter coupled to the first interior side and configured to emit emitted energy, a detector coupled to the second interior side and configured to receive detected energy, and a wireless transceiver coupled to the body and configured to transmit data corresponding to at least one of the emitted energy and the detected energy.

A method and apparatus deliver a variable flow of oxygen to a patient. The apparatus may include a flow control valve, a pressure sensor to detect a patient's breathing pressure and ambient pressure, an oxygen flow analyzer to measure oxygen flow to the patient, and a processor to analyze the breathing pressure values, ambient pressure value, and oxygen flow rate values and to determine when a patient is inhaling. When the processor determines the patient is inhaling, the processor calculates an optimal oxygen flow rate to deliver to a patient, which may depend on a pre-selected flow rate and an oxygen backlog, and the processor sends a signal to the flow control valve to deliver the optimal oxygen flow rate to the patient.

Resuscitation and ventilation monitoring devices are provided. A device includes an inlet in fluid communication with airflows exchanged with lungs of a patient and an airflow meter for measuring characteristics of the airflows. A user may provide a controller with patient information, e.g., height, weight, gender, or age, via a measurement selector, enabling the controller to determine acceptable ranges of measured airflow characteristics. The device may determine a current mode of ventilation and associated ventilator settings based on the measured airflow characteristics. The device may also identify and filter out artifacts present in the ventilation signal, and determine whether a respiratory failure phenotype is present in the ventilation. If the current mode of ventilation and associated ventilator settings fall outside an acceptable range, the ventilation is classified as off-target and the controller may cause a sensory alarm to alert the user. The device may suggest a corrective action based on the type of off-target ventilation detected. The device may also continuously analyze ventilation to determine changes in lung compliance over time and to identify pathological changes over time. The device may work within a network of devices and user interfaces via wired or wireless communication, and is not restricted to or dependent on the type of ventilatory device with which a patient is being supported.

A processor obtains input of a logistically attainable end tidal partial pressure of gas X (PetX[i].sup.T) for one or more respective breaths [i] and input of a prospective computation of an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX[i].sup.T for a respective breath [i] using inputs required to utilize a mass balance relationship, wherein one or more values required to control the amount of gas X in a volume of gas delivered to the subject is output from an expression of the mass balance relationship. The mass balance relationship is expressed in a form which takes into account (prospectively), for a respective breath [i], the amount of gas X in the capillaries surrounding the alveoli and the amount of gas X in the alveoli, optionally based on a model of the lung which accounts for those sub-volumes of gas in the lung which substantially affect the alveolar gas X concentration affecting mass transfer.