A system for contactless monitoring of gas levels within an incubator, the system comprising at least one gas sampling line having a proximal end exposed to the internal space of the incubator, and a distal end associated with a monitoring unit for receiving a gas sample obtained from the incubator via the proximal end.

The disclosure is directed to an apparatus and a method for improving manual ventilation and resuscitation by monitoring ventilation parameters and assisting resuscitation. The apparatus includes a gas flow sensor configured to measure a flow rate of exhaled gas of a subject. The apparatus is configured to receive an ideal body weight or a predicated body weight of the subject and calculate a first tidal volume range based on the ideal body weight or the predicated body weight of the subject. The apparatus is also configured to obtain an exhaled tidal volume of the subject based on the measured flow rate and determine whether the exhaled tidal volume is within the first tidal volume range. When it is determined that the exhaled tidal volume is not within the first tidal volume range, the apparatus is further configured to perform a first tidal volume warning.

A universal respiratory detector for detecting a respiratory gas. The universal respiratory detector may include a plurality of layers with a visual indicator to quickly and reversibly change color to detect a respiratory gas parameter such as carbon dioxide. The color change may be visible from both sides of the detector. In some examples, the respiratory detector may be a biocompatible and conformable sticker for mounting on a person’s face or an oxygen delivery device.

A device and a method for metabolism monitoring of a user based on low-cost, energy-effective and ultra-compact metal-oxide semiconductor (MOS) sensor are provided. The device provides information on metabolism/nutrition/physical activity of the user based on measuring the MOS sensor resistance proportional to a ratio of oxygen (O2) to carbon dioxide (CO2) concentrations in exhaled air.

Devices and methods are provided for breath gas analysis when determining the difference in the concentrations of at least one gas in the exhaled breathing air on the one hand and in the ambient air on the other hand. The device may include at least one gas sensor, by means of which the concentration of a gas can be determined, and a line system, through whose lines the exhaled air to be examined, the ambient air and a calibrating gas can be selectively pumped to the gas sensor. The method may include feeding ambient air; feeding calibrating gas to the gas sensor; feeding exhaled air to the gas sensor; feeding calibrating gas to the gas sensor again; and feeding exhaled air to the gas sensor again.

Systems and methods for measurement of end tidal carbon dioxide, including a device having a body and a tubular gas line. The body is adapted to be attached to a patient airway and has a first gas line securing portion which has an aperture through it and is adapted to secure the gas line to the body. The tubular gas line is secured in the aperture. The tubular gas line has a proximal portion extending from a proximal end of the aperture and has a proximal end which is adapted to be connected to an end tidal CO2 monitor. The tubular gas line also has a distal portion extending from a distal end of the aperture and having a distal end which provides an inlet for end tidal CO2 exhaled by a patient.

The present disclosure describes a system for metabolic monitoring comprising: collecting exhaled gas from nasal airways of a subject; a mixing chamber for receiving a portion of the exhaled gas; a plurality of sensors for outputting signals related to gas parameters related to inhaled gas and exhaled gas during one or more breaths; and processors configured to determine a flow rate of gas in the interface appliance; determine pressure changes near the mouth of the subject to detect mouth breathing of the subject; determine concentration measurements of O2 and CO2 of the portion of the exhaled gas in the mixing chamber, and discard concentration measurements corresponding to mouth breathing; determine a rate of oxygen consumption VO2 and a carbon dioxide production VCO2 of the subject based on the determined flow rate, the CO2 concentration, and the determined O2 concentration.

Methods of and devices for detecting a measurable characteristic of the gas sample. The methods and devices are able to detect a value of or a change of measurable characteristic (e.g., such as chemical concentrations), a change of chemical compositions and/or biological responses of a living organism that are induced by a stressor. The biological responses are able to include cellular stress, damage, and immune responses. The stressor is able to include an exposure to ionizing radiation. The effects of the stressors are able to be monitored in terms of changes in the chemical concentrations and chemical compositions in an exhaled breath. The chemicals are able to function as bio-markers. The chemicals that are to be monitored are able to include nitric oxide, carbon monoxide, carbon dioxide, ethane, and other molecules related to specific disease resulting from the stressor.

An aspect of the present invention is a loss-of-consciousness estimation apparatus including: an out-of-range data determination unit configured to execute out-of-range data determination processing for, using an amount correlated with a cerebral blood flow rate of an estimation target as a cerebral blood flow correlation amount, a time series of the cerebral blood flow correlation amount as a cerebral blood flow correlation amount time series, and a position in a time axis direction of data of the cerebral blood flow correlation amount time series as a time position, determining whether or not the cerebral blood flow correlation amount indicated by each piece of the data is out of range of a threshold region, which is a range corresponding to the time position of each piece of the data, based on the cerebral blood flow correlation amount time series; and a ventricular state estimation unit configured to estimate a ventricular state of the estimation target based on the determination result of the out-of-range data determination unit, in which, before the execution of the out-of-range data determination processing, the out-of-range data determination unit executes processing for determining the threshold region of each time position, which is processing for determining the threshold region that is to be determined according to a distribution of the data in a first period, which is a period of a first length including the time position at which the threshold region is determined.

Methods and devices to capture and analyze aerosolized particles such as protein biomarkers and their truncated proteoforms characteristic of a disease, including a respiratory disease, in exhaled breath to enable rapid detection of diseases are disclosed. The disclosed methods and systems selectively capture aerosolized particles using a packed bed column. The captured particles are then eluted using one or more solvents and analyzed using devices including mass spectrometry.