Biosensor performance indicator systems for orthodontic appliances. An orthodontic appliance system may include at least one biosensor system having a bioreceptor configured to cause an interaction with a biomarker in fluid in an oral cavity. The biomarker may be associated with a velocity of tooth root movement. A biotransducer may be coupled to the bioreceptor. The biotransducer may be configured to transduce the interaction into an interaction signal representative of the interaction. A processor may be configured to receive sensor data corresponding to the interaction signal and, based on the sensor data, provide one or more recommendations to change the orthodontic appliance or modify an orthodontic treatment plan when the interaction signal is below a threshold.

A method, user interface and system for detecting and monitoring development of a dental condition. In particular, detecting and monitoring such a development by comparing digital 3D representations of the patient's set of teeth recorded at a first and a second point in time. For example, determining tooth movement for at least one tooth between the first and second point in time based on derived distances.