Devices and methods are described herein for directly and accurately measuring sweat flow rates using miniaturized thermal flow rate sensors. The devices (100, 200, 300, 400, 500, 600, 700, 800, 900, 1000, 1100, 1200, 1300, 1400, 1500) include the flow rate sensors (220, 320, 420, 520, 620, 720, 820, 920, 1020, 1120, 1220, 1320, 1420) in or adjacent to a microfluidic component (230, 330, 430, 530, 630, 730, 830, 930, 1030, 1130, 1230, 1330, 1430, 1530) of a wearable sweat sensing device. The devices and methods optimize the sensitivity of the flow rate sensors, while minimizing the presence of noise, in order to accurately and directly measure sweat flow rates.

Provided is a sweat sensing device (100). The device comprises a body (102) for positioning against skin (104). A recess (108) is defined in the body for receiving sweat from a skin area. The device further comprises an optical detection assembly (114) configured to detect a discrete sweat droplet (106) protruding into the recess from a sweat pore (110) in the skin area, and a fluidic system (116) configured to transport the sweat droplet (106) away from the recess (108) following detection of the sweat droplet by the optical detection assembly (114).

Embodiments herein include testing articles to assess hydration of a test subject. The testing articles can include a carrier portion having a porous medium through which a fluid of the test subject moves. The carrier portion can include a first end and a second end opposite the first end. The testing articles can include a first chemical composition disposed in the porous medium that reacts with chloride ions to produce a first color change. The testing articles can include a wick that is in direct contact with the first end of the carrier portion to allow the transfer of the fluid from the wick to the carrier portion. The testing articles can include a fill indicator element in direct contact with the second end of the carrier portion to allow the transfer of the fluid from the carrier portion to the fill indicator element. Other embodiments are also included herein.

Conformable and wearable sensors with integrated on-chip gate for the detection of biomolecules, chemicals, and other substrates and applications thereof are provided. Biosensor chips can be built with In2O3 nanoribbon field-effect transistors. Biosensor chips can conform to features of a human body, enabling ability for individuals to wear a biosensor.

The disclosed technology provides a system and a computer implemented method for crisis state detection and intervention of a person or group of persons, the method comprising: providing a computer system designed to detect and intervene non-normal, elevated crisis operating states; using one or more sensors that ascertains a crisis state via physical, behavioral, or cognitive indicators; deducing, with computational hardware, the operational state of a user or users from one or more sensors; and administering an immediate, dual intervention of a sensory form to de-escalate the crisis operating state of a person or group of persons.

Disclosed herein are devices for measuring sweat that are substantially clogging free, having low dead volumes, and allowing a quick sensory response. Also disclosed herein are methods of making and using such devices.

Disclosed is a hormone electrochemical biosensor, e.g. an amperometric biosensor, for the detection of a hormone and measurement of the concentration of a hormone. The disclosed hormone biosensor comprises a hormone-catalyzing enzyme, such as KSDH1. Also described herein are systems comprising an amperometric biosensor, e.g., chronoamperometric biosensor and methods of using the chronoamperometric biosensor.

A detection apparatus detects at least one chemical species in the sweat of a human or animal subject, the at least one chemical species being selected from the group consisting of nitrogen oxide NO, nitrite ion NO2— and hydrogen peroxide H2O2. The apparatus has a collection element that is intended to be positioned in an investigation zone of an epidermis of the subject, and a detection device has at least one fluid circuit that is coupled to the collection element in order to direct at least one flow of sweat from the investigation zone and an electrochemical sensor having electrodes that are arranged in the fluid circuit, the electrochemical sensor being configured to produce a signal that represents a concentration of the at least one chemical species in the flow of sweat and a signal that represents a flow speed of the flow of sweat.

Presented herein are systems, methods for collecting fluid from a surface (e.g., skin) and analyzing the fluid (e.g., to measure chemical, physical and/or biological properties of the fluid). For example, a system for fluid collection on a surface (e.g., skin) and fluid analysis includes at least one of the following modules: (i) a collection and delivery module to collect a fluid over a wet or partially wet surface and deliver it to (ii) a main sensing module to perform chemical, physical and/or biological analysis on the fluid. The system also includes (iii) a flow regulation module, for controlling fluid flow (e.g., transport) through the system and (iv) a waste module to collect and/or dispose of the fluid after analysis is complete.

A system having a scope with a longitudinal length extending between a proximal end and a distal end includes a plurality of markers spaced along the longitudinal length. The system also includes a disassociation and positioning device that is configured to enhance unsedated transnasal endoscopic procedures by at least partially occluding the vision of a patient while enabling body cavity access, and optionally record and sense body functions such as temperature, heart rate and oxygenation of the blood stream. The system further includes a sensor integrated into the distraction device, wherein the sensor is configured to detect the markers on the longitudinal length of the scope.