Typical electrochemical sensors measure target-induced changes in current output. Such measures of target binding are inconsistent across individual sensors, and furthermore, signal will drift over time when the sensor is deployed for long periods. These shortcomings can be avoided by the novel use of chronoamperometry to measure current decay kinetics as the indicator of target binding. Current decay lifetimes will vary in a concentration dependent manner, but remain stable across individual sensors and over time, allowing for calibration-free operation. By these methods, aptamer based electrochemical sensors and other sensor types may be deployed in vivo for extended periods of time and will provide accurate measurement of target binding without calibration.

A sweat collection device includes a flexible body having a first, outwardly facing surface and a second, skin-facing surface, and a sweat collection channel formed in the body, the sweat collection channel having a first end defining a sweat inlet port, and a second end defining a sweat outlet port. The sweat inlet port and the sweat outlet port are configured to be closed and sealed such that the sweat collection device and the collected sweat therein may be stored and shipped.

The present disclosure relates to a biosensor for measuring glucose in a biological sample, which contains a filter unit formed of a cytoplasmic membrane, which allows selective permeation of glucose in a biological sample. The biosensor of the present disclosure, which contains the cytoplasmic membrane filter unit allowing selective permeation of glucose in the biological sample, exhibits high glucose detection sensitivity as compared to the commercially available blood sugar measuring sensors and also exhibits high glucose detection specificity despite the addition of signal-interfering substances such as fructose, xylose, maltose, cysteine, ascorbic acid, uric acid, galactose, etc. In addition, because he cytoplasmic membrane filter unit contained in the biosensor for measuring glucose of the present disclosure is not significantly affected by the moisture in the air, it can be applied to various products such as a disposable blood sugar test strip or an attachable or implantable glucose measuring device.

The present invention provides a chemical sensor that can be manufactured at low cost and has high detection sensitivity. The chemical sensor according to the present invention is characterized by comprising: a substrate; a semiconductor thin film having a first contact region and a second contact region; an injection electrode; a first MIS structure; a second MIS structure; a transfer electrode; and a capacitor, wherein the semiconductor thin film has a sensing region provided so that an electric potential thereof changes in direct or indirect response to an object to be measured; the injection electrode is configured to inject an electrical charge into the first contact region; the first MIS structure is configured to control a flow of the electrical charge to the sensing region, the electrical charge being injected into the first contact region by the injection electrode; the second MIS structure is configured to control the flow of the electrical charge from the sensing region to the second contact region; and the transfer electrode is configured to allow the electrical charge in the sensing region to flow to the capacitor through the second contact region.

Described herein is an amperometric biosensor, e.g., chronoamperometric biosensor for the measurement of the concentration of nicotine. Also disclosed herein is a wearable nicotine biosensor device and a biosensor that detects nicotine in smoke. The biosensor disclosed herein comprises a nicotine-catalyzing enzyme, such as NicA2 or mutant NicA2 enzymes. Also described herein are systems comprising said amperometric biosensor, e.g., chronoamperometric biosensor and methods of using said chronoamperometric biosensor.

The present invention is directed to a wearable system wherein elements of the system, including various sensors adapted to detect biometric and other data and/or to deliver drugs, are positioned proximal to, on or in the ear canal of a person. In embodiments of the invention, elements of the system, including drug delivery devices, are positioned on or in the ear canal for extended periods of time. For example, an element of the system may be positioned on the tympanic membrane of a user and left there overnight, for multiple days, months, or years. Because of the position and longevity of the system elements in the ear canal, the present invention has many advantages over prior wearable biometric and drug delivery devices.

Methods, systems, and devices are described herein for various embodiments of using a sample analysis system to analyze a sample of bodily fluid from a user to determine parameters associated with the user including states of hydration, dehydration, rehydration, electrolyte loss, wellness, recovery, and the like. In some embodiments, the methods disclosed can be implemented using a device worn by a user, and operatively coupled to a sample analysis system configured to collect a sample of bodily fluid, and measure and analyze the bodily fluid to determine a property of the bodily fluid and/or a physiological/wellness parameter (e.g., degree of hydration, electrolyte losses, perspiration rate, etc.) of the user.

A wearable measuring device is provided. The wearable measuring device includes a wearable element, a liquid-transferring element, a bio-sensing electrode, a flow-sensing electrode, and a meter. The wearable element has an opening. The liquid-transferring element is disposed in the wearable element and has a sampling portion exposed to the outside through the opening. The bio-sensing electrode and the flow-sensing electrode are connected to a first position and a second position of the liquid-transferring element. The meter is disposed on or in the wearable element and is electrically connected to the bio-sensing electrode and the flow-sensing electrode.

The system features a a method for mood tracking and delivery of a digital/dosage-dependent therapeutic, comprising the steps of: detecting a release of a mood-governing chemical in a user's body via an adhesive detector patch (ADP); assessing and tracking of the mood-governing chemical to determine an emotional or mental state (EMS) of a user; and delivering at least a primary-level message (digital therapeutic) personalized to the user based on at least one of a stored message coupled to the emotional and mental state (EMS).

A wearable device for determining risk of an underlying health concern is disclosed. The wearable device comprises a replaceable medium for absorbing perspiration of a user, wherein the replaceable medium is at least occasionally in contact with the user. The device also includes a power source electrically connected to the medium, and a resistance detector processor for periodically detecting the electrical resistance of the absorbed perspiration, wherein the electrical resistance of the absorbed perspiration is dependent on the salinity of the perspiration. Further, the device includes a risk detector processor for: (1) determining whether the detected resistance meets at least one condition, and (2) triggering an alert signal if the at least one condition is met, a storage device for storing resistance values; and a warning signal generator for providing a warning signal to the user based on the alert signal.