A microneedle device comprising a membrane having an adhesive thereon and a microneedle substrate adhered to the membrane via the adhesive. The microneedle substrate may have a plurality of microneedles coupled thereto, or the microneedle substrate can comprise the plurality of microneedles. The microneedle device can be mated with a reagent container and the microneedles aligned with wells on the reagent container said wells configured to hold reagents thus comprising a system for detecting opioids or other drugs. In another embodiment, the device comprises a sweat-absorbent swatch adhered to a membrane. This embodiment can be mated to a screening pad comprising blisters of reagents on the base layer of the screening pad. Upon mating, a needle device can be used to pierce the blisters such that the reagents are released and react with the sweat absorbent swatch to indicate the presence of opioids or other drugs.

A physiological signal sensing and compensation system is provided, for contacting an object to be measured and sensing a physiological signal. The physiological signal sensing and compensation system includes a physiological signal sensing module, a compensation module, and a computing unit. The physiological signal sensing module provides an initial sensing signal. The compensation module includes a collecting mechanism for collecting a physiological liquid of the object to be measured. The compensation module provides a compensation signal according to the physiological liquid collected by the collection mechanism. The computing unit is electrically connected to the physiological signal sensing module and the compensation module, and calculates and provides a compensated sensing signal based on the initial sensing signal and the compensation signal.

An intelligent wearable device is disclosed. The intelligent wearable device is configured to monitor and obtain biological data associated with a user wearing the device and environmental data associated with an environment that the user is located in through the use of a plurality of sensors of the wearable device. Once the biological and environmental data are obtained, the intelligent wearable device may compare the data to a threshold value that is associated with the safety of the user. If the comparison indicates that the data is outside the threshold value, the intelligent wearable device may output a signal indicating that the user is experiencing an event. The intelligent wearable device may also generate feedback indicating an action to perform in response to the event. The intelligent wearable device may notify devices associated with other users, who may be able to assist the user experiencing the event.

Described herein are apparatuses (e.g., garments, including but not limited to shirts, pants, and the like) for detecting and monitoring physiological parameters, such as respiration, cardiac parameters, and the like. Also described herein are methods of forming garments having one or more stretchable conductive ink patterns and methods of making garments having one or more highly stretchable conductive ink pattern formed of a composite of an insulative adhesive, a conductive ink, and an intermediate gradient zone between the adhesive and conductive ink. The conductive ink typically includes between about 40-60% conductive particles, between about 30-50% binder; between about 3-7% solvent; and between about 3-7% thickener. The stretchable conductive ink patterns may be stretched more than twice their length without breaking or rupturing.

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Technologies and implementations for wearable healthcare devices are generally disclosed. An example method performed by a wrist-wearable device includes: detecting, by a sensor, a physiological parameter of a user; determining, by a processor based on the physiological parameter, that the user is experiencing atrial fibrillation (AF); outputting, by a display, a visual signal indicating that the user is experiencing the AF; and transmitting, by a transceiver to a first external computing device, a first wireless signal indicating that the user experienced the AF.

A monitoring apparatus for monitoring a subject (14) is disclosed. The monitoring apparatus comprises a storage device (18) for storing first skin secretion data (27) of the subject. A detection unit (12) detects a skin secretion at a skin portion of the subject and provides second skin secretion data (28) of the subject. An evaluation unit (16) evaluates the second skin secretion data and determines at least one physical parameter on the basis of the first skin secretion data and the second skin secretion data. One of the at least one physical parameter is a time value (25, 26) determinable on the basis of a difference between the first and the second skin secretion data.

Bodily fluid indicator devices and methods are provided. Such devices and methods can effectively indicate whether the amount of bodily fluid being produced is within a measurable range. In an exemplary embodiment, a bodily fluid indicator device includes a substrate having a surface. Some portions of the surface are covered with a region of absorbent material and other portions of the surface are devoid of the absorbent material. A graduated scale or a reactive feature is printed on the absorbent material. The device is configured to indicate an amount and/or a composition a bodily fluid present on an area of a patient or subject.

A mobile touchable system for user fitness and health monitoring is presented. The system is designed in one form as a mobile phone case and in another form as integrated in a mobile phone. It encompasses a series of measurement devices, including, but not limited to, arrays of electrodes for bio-impedance analysis, impedance tomography, and electrocardiographs, near-infrared spectroscopy for glucose level measurement, and heart rate monitoring. The touchable system performs incidental measurement in the background each time the user holds the mobile phone and hence enables long term health monitoring without user intervention. The touchable monitoring system further performs targeted spot measurements by following defined procedures. Spot measurement is enhanced through an extension measurement cable. Furthermore, an extension strap along with the mobile touchable system provides detailed activity tracking. The touchable system performs long term health monitoring, and provides early alerts for abnormal condition such as diabetes, dehydration, hypertension, cardiovascular anomalies, breast cancer and prostate cancer.

The invention provides a versatile sensing platform for sensing and analysis of biofluids, particularly well-suited for sensing and analysis of sweat. Systems of the invention allows for sensitive and selective detection of a range of analytes in sweat including metabolites, electrolytes and biomarkers. Systems of the invention provide a noninvasive and accurate means for quantitative characterization of important sweat characteristics including sweat volume, sweat loss and sweat rate. Systems of the invention are compatible with materials and device geometries for important class of conformal tissue mounted electronic devices, including epidermal electronic devices.