Novel tools and techniques are provided for physiological monitoring. A method includes receiving, with a computing system, physiological data of a user, analyzing, with the computing system, the received physiological data of the user to identify at least one of one or more body states or one or more transitions between body states of the user, and determining, with the computing system, at least one physiological state of the user, based at least in part on an analysis of the identified at least one of the one or more body states or the one or more transitions between body states of the user. The method further includes sending, with the computing system and to a user device, the determined at least one physiological state of the user, and displaying, on a display screen of the user device, the determined at least one physiological state of the user.

The present disclosure provides a method for detection of an analyte in a sample, comprising contacting a biological sample with a biosensor comprising a container or substrate and a gold (III) chloride gel comprising a plurality of gold chloride nanoparticles, determining an optical condition for the sample, and detecting a concentration of the analyte in the sample based on the optical condition. The method can be used for diagnosing an eye condition in a subject. The present disclosure also provides biosensors and kits for the detection of an analyte.

A wearable consumer electronic product includes at least a housing arranged to carry operational components comprising a processor and a band having a pliable band body and a securing means arranged to secure the band body to the housing. In one embodiment, the pliable band body has a size and shape suitable for wrapping around an individual appendage and that includes an opening that leads to a cavity within the band body suitable for accumulating an amount of water and a band sensor embedded within the band body in communication with the cavity.

The present invention provides electrochemical biosensors for measuring low concentrations of analytes in biological fluid samples. The biosensors comprise one or more working electrodes, a reference electrode, a counter electrode, and a bio-cocktail. The bio-cocktail comprises one or more enzymes and one or more redox mediators in a buffered solution. The present invention also provides methods of measuring low concentrations of analytes in biological fluid samples using the electrochemical biosensors of the invention.

Embodiments describing an approach for detecting user biomarker identifier changes based on audio preferences and generating biometric alerts based on the detected biomarker identifier changes. Receiving a user's current audio preferences. Retrieving the user's historic audio preferences and biometric data associated with the user's historic audio preferences. Analyzing the user's current audio preferences based on the user's historic audio preferences and the biometric data associated with the historic audio preferences. Creating a user biometric profile based on analyzing the user's current audio preferences, the user's historic audio preferences and the biometric data associated with the user's historic audio preferences; and outputting the user biometric profile.

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

An infection sensing system includes a sensor device configured to be fastened onto the skin, the sensor device including multiple sensors and a processor coupled to the sensors. The sensors include at least a temperature sensor to read skin temperature as a proxy for body temperature and a heart rate sensor. The processor inputs data from the sensors, determines data representing body temperature and heart rate, and identifies a combination of: (i) a greater than threshold temperature fluctuation in the body temperature, and (ii) a greater than threshold heart rate, where (i) and (ii) are present for greater than a threshold time duration. Responsive to this identification the system outputs data indicating infection.

The present invention presents a method of fabrication for a physiological sensor with electronic, electrochemical, and chemical components. The fabrication method comprises steps for manufacturing an apparatus comprising at least one electrochemical sensor, a microcontroller, and a transceiver. The fabrication process includes the steps of substrate fabrication, circuit fabrication, pick and place, reflow soldering, electrode fabrication, membrane fabrication, sealing and curing, layer bonding, and dressing. The physiological sensor is operable to analyze biological fluids such as sweat.

Embodiments herein include testing articles to assess hydration of a test subject. The testing articles can include a carrier portion having a porous medium through which a fluid of the test subject moves. The carrier portion can include a first end and a second end opposite the first end. The testing articles can include a first chemical composition disposed in the porous medium that reacts with chloride ions to produce a first color change. The testing articles can include a wick that is in direct contact with the first end of the carrier portion to allow the transfer of the fluid from the wick to the carrier portion. The testing articles can include a fill indicator element in direct contact with the second end of the carrier portion to allow the transfer of the fluid from the carrier portion to the fill indicator element. Other embodiments are also included herein.

Devices and methods of making and using the device for the non-invasive detection of volatile anesthetics are provided. The devices are capable of measuring the concentration of volatile anesthetics transdermally and in a non-invasive manner. The devices and methods can be applied in detection of volatile anesthetics in samples collected from human skin perspiration.