A system to determine medication adherence may include a chemical marker sensor, a verification sensor, and a processor. The chemical marker sensor may be configured to detect one or more markers in sweat vapor of a user. The verification sensor may be configured to detect whether the system is in use. The processor may be communicatively coupled to the chemical marker sensor and the verification sensor and may be configured to determine whether the user has taken a therapeutic agent that includes the one or more markers based on signals generated by the chemical marker sensor and the verification sensor.

A biodegradable system includes a biodegradable substrate which can be a biodegradable paper or polymer. A biodegradable power source is printed or deposited above the substrate, and biodegradable processor and communication circuits are in turn formed on the substrate. The processor and wireless communication system can communicate with a remote computer to provide information about the source of the items (optionally tracked using the blockchain supply chain tracking), the relevant dates (production and expiration dates), any attempt to tamper with the packaging, and suitable warnings or usage instructions, for example. Optionally, a biodegradable display can render information to a customer, for example.

According to an aspect, there is provided switch circuitry (1) for controlling power supplied to a fluid monitoring unit (4). The switch circuitry (1) comprises: a sensor (2) configured to detect fluid derived from the skin of a user and to generate a detection signal in response to detection of fluid; and a controller (3) configured to receive the detection signal, to generate a wake-up signal in accordance with the detection signal, and to supply the wake-up signal to a switch (6) controlling the power supply to the fluid monitoring unit (4) so as to activate the switch (6) and wake the fluid monitoring unit (4), wherein, optionally, the fluid is sweat. According to another aspect, there is provided method of controlling power to a fluid monitoring unit.

A microfluidic system includes a flexible substrate having a skin-facing surface and a back-facing surface; a microfluidic network at least partially embedded in or supported by the flexible substrate; a sensor fluidically connected to the microfluidic network, wherein the microfluidic network is configured to transport a biofluid from a skin surface to the sensor; and a capping layer, having a capping layer skin-facing surface and a back-facing surface, wherein the back-facing surface of the capping layer is attached to the skin-facing surface of the substrate. The flexible substrate is at least partially formed of a thermoplastic elastomer or a polymer configured to provide a high barrier to vapor or liquid water transmission.

The present invention presents a method of fabrication for a physiological sensor with electronic, electrochemical, and chemical components. The fabrication method comprises steps for manufacturing an apparatus comprising at least one electrochemical sensor, a microcontroller, and a transceiver. The fabrication process includes the steps of substrate fabrication, circuit fabrication, pick and place, reflow soldering, electrode fabrication, membrane fabrication, sealing and curing, layer bonding, and dressing. The physiological sensor is operable to analyze biological fluids such as sweat.

A wearable biometric sensing ring apparatus for continuous heart rate and blood pressure monitoring having a ring housing for retention on a finger of a user, an electrodermal activity (EDA) sensor disposed within the housing so as to contact a location of the skin of the finger when the housing is retained on the finger, the EDA sensor configured for measuring changes in skin impedance indicative of SNS activation; a biometric sensor disposed within the housing in proximity to the EDA sensor so as to contact at or near the location of the skin of the finger. Application software is provided for assessing the physiological state of the user based on acquired EDA sensor data and biometric sensor data.

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Aspects of the present disclosure provide a method for obtaining biological information associated with a user, comprising receiving electrical signals via a first electrode on an ear tip of an earpiece inserted in an ear of the user, receiving electrical signals via a second electrode on an external portion of the earpiece, and deriving an electrocardiogram (ECG) based on the signals received via the first electrode and the second electrode. Aspects also provide a method for determining a pulse travel time (PTT) associated with a user, comprising obtaining a proximal signal using an earpiece inserted in of the user, obtaining a distal signal using the earpiece, and deriving the PTT based on the obtained proximal signal and the obtained distal signal.

The disclosed invention provides a fluid sensing device and method capable of collecting a fluid sample, concentrating the sample with respect to one or more target analytes, and measuring the target analyte(s) in the concentrated sample. The invention is also capable of determining the change in molarity of the fluid sample with respect to the target analyte(s), as the sample is concentrated by the device. The invention further includes a method for using a fluid sensing device to concentrate a fluid sample with respect to one or more target analytes. The disclosed method further includes the ability to correlate the measured target analyte concentration to a physiological condition of a device wearer, or of a fluid source.

A system to measure sweat vapor may include a skin contact sensor, a sweat vapor sensor, and a processor. The skin contact sensor may be configured to measure one or more aspects indicative of whether the measuring device is in contact with skin of a user of the measuring device. The sweat vapor sensor may be configured to measure one or more properties of sweat vapor of the user; and the processor may be communicatively coupled to the skin contact sensor and the sweat vapor sensor. The processor may be configured to confirm operation of the measuring device based on the one or more aspects measured by the skin contact sensor, and the sweat vapor sensor receiving the sweat vapor.