Among others, the present invention provides devices each including a micro-filter, a shutter, a cell counter, a selector, a micro-surgical kit, a timer, and a data processing circuitry, wherein the micro-filter is capable of detecting or filtering circulating tumor cells.

The present invention is directed to a wearable system wherein elements of the system, including various sensors adapted to detect biometric and other data and/or to deliver drugs, are positioned proximal to, on the ear or in the ear canal of a person. In embodiments of the invention, elements of the system are positioned on the ear or in the ear canal for extended periods of time. For example, an element of the system may be positioned on the tympanic membrane of a user and left there overnight, for multiple days, months, or years. Because of the position and longevity of the system elements in the ear canal, the present invention has many advantages over prior wearable biometric and drug delivery devices.

Devices for calibrating electrochemical aptamer-based biofluid sensors. In some embodiments a calibrant is located proximate to the EAB sensors, and calibration is facilitated by introduction of the biofluid into the device. Other embodiments include various mechanisms for introducing calibration solution to the sensors, including drawing calibration solution into contact with sensors through electrical potential, a dispensing mechanism such as an ink jet-type nozzle, as well as pressure actuated calibration dispensing. Also included are embodiments employing bifurcated biofluid transport paths that allow alternately for calibration and biofluid sensing.

Embodiments describing an approach for detecting user biomarker identifier changes based on audio preferences and generating biometric alerts based on the detected biomarker identifier changes. Receiving a user's current audio preferences. Retrieving the user's historic audio preferences and biometric data associated with the user's historic audio preferences. Analyzing the user's current audio preferences based on the user's historic audio preferences and the biometric data associated with the historic audio preferences. Creating a user biometric profile based on analyzing the user's current audio preferences, the user's historic audio preferences and the biometric data associated with the user's historic audio preferences; and outputting the user biometric profile.

The disclosed invention provides a biofluid collection device configured with an open microfluidic network, which facilitates nanoliter-scale biofluid collection and transport for biosensing applications. In one embodiment, a biofluid sensing device placed on the skin for measuring a characteristic of an analyte in sweat includes one or more biofluid sensors and a hexagonal open microfluidic network biofluid collector. The disclosed collector provides a volume-reduced pathway for sweat biofluid between the one or more sensors and sweat glands when the device is positioned on the skin. In another embodiment, a biofluid collector includes a network of microchannels comprising three or more repeatedly intersecting channels that provide redundant pathways for biofluid transport. Embodiments of the disclosed invention are also directed to highly stable peptide-based self-assembled monolayers (SAM) and methods of making the SAMs. In some embodiments, the peptide-based SAM is formed on a component of a biofluid sensing device.

Systems, devices, methods, and kits for monitoring one or more physiologic and/or physical signals from a subject are disclosed. A system including patches and corresponding modules for wirelessly monitoring physiologic and/or physical signals is disclosed. A service system for managing the collection of physiologic data from a customer is disclosed. An isolating patch for providing a barrier between a handheld monitoring device with a plurality of contact pads and a subject is disclosed.

A head guard is provided. The head guard includes one or more sensors as part of an sensory input and communications system. The head guard wirelessly communicates data to remote computing devices for intelligent data collection.

Various embodiments disclosed relate to a wearable assay system. The wearable assay system includes a first external surface adapted to contact a wearer and a void defined by a portion of the first external surface. A sample collection probe is positioned near the void and is attached to the first external surface. The sample collection probe is adapted to collect a biological sample from the wearer. An assay unit is adapted to receive the biological sample from the sample collection probe. An actuation system is adapted to position the assay unit in contact with the sample collection probe. A detection system is adapted to detect a property of the biological sample.

Described herein are apparatuses (e.g., garments, including but not limited to shirts, pants, and the like) for detecting and monitoring physiological parameters, such as respiration, cardiac parameters, and the like. Also described herein are methods of forming garments having one or more stretchable conductive ink patterns and methods of making garments having one or more highly stretchable conductive ink pattern formed of a composite of an insulative adhesive, a conductive ink, and an intermediate gradient zone between the adhesive and conductive ink. The conductive ink typically includes between about 40-60% conductive particles, between about 30-50% binder; between about 3-7% solvent; and between about 3-7% thickener. The stretchable conductive ink patterns may be stretched more than twice their length without breaking or rupturing.

A system and method for auto-regulating therapeutic administration to a patient for achieving artificial homeostasis. The system includes a plurality of modules designed to create an automated therapeutic administration system. An auto-regulation module maintains a target vital level within a patient by comparing measured levels with stored target levels; a delivery module delivers an amount of a therapeutic to a patient based on instructions from the auto-regulation module, and a sensor module measures patient levels and transmits the measurements to the auto-regulation unit. The auto-regulation module compares the measured levels with the stored target levels, and, based on the comparison, instructs the delivery module to alter the amount of therapeutic administered to the patient, in an effort to match the measured levels with the target levels, thereby creating a closed feedback loop designed to achieve an artificial homeostasis for a patient.