A wearable sweat sensing device configured to be placed on a wearer's skin includes a sensor component, including at least one analyte-specific sensor for measuring a target analyte in sweat, and at least one electromagnetic shield to protect at least a portion of the sensor component from electromagnetic interference. The at least one electromagnetic shield may include a first electromagnetic shield for protecting the sensor component from electromagnetic interference originating outside the wearer's body and a second electromagnetic shield for protecting the sensor component from electromagnetic interference originating from the wearer's body or propagating through the wearer's body.

Bodily fluid indicator devices and methods are provided. Such devices and methods can effectively indicate whether the amount of bodily fluid being produced is within a measurable range. In an exemplary embodiment, a bodily fluid indicator device includes a substrate having a surface. Some portions of the surface are covered with a region of absorbent material and other portions of the surface are devoid of the absorbent material. A graduated scale or a reactive feature is printed on the absorbent material. The device is configured to indicate an amount and/or a composition a bodily fluid present on an area of a patient or subject.

Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.

A system and apparatus is disclosed for indicating a window of fertility based on the fertility awareness method (FAM).

Devices and methods of making and using the device for the non-invasive detection of volatile anesthetics are provided. The devices are capable of measuring the concentration of volatile anesthetics transdermally and in a non-invasive manner. The devices and methods can be applied in detection of volatile anesthetics in samples collected from human skin perspiration.

The disclosed invention provides a fluid sensing device and method capable of collecting a fluid sample, concentrating the sample with respect to one or more target analytes, and measuring the target analyte(s) in the concentrated sample. The invention is also capable of determining the change in molarity of the fluid sample with respect to the target analyte(s), as the sample is concentrated by the device. The invention further includes a method for using a fluid sensing device to concentrate a fluid sample with respect to one or more target analytes. The disclosed method further includes the ability to correlate the measured target analyte concentration to a physiological condition of a device wearer, or of a fluid source.

Some embodiments relate to a reconfigurable biosensor adapted for performing tests in a plurality of modes or a smartphone or wearable device comprising the reconfigurable biosensor.

Described here are patches and methods for measuring glucose in sweat (and tears and the like). In general, the patches comprise an adhesive layer adapted to bond to skin of an individual, a substrate layer disposed over the adhesive layer and comprising a glucose sensing complex including a chromogen that changes color in the presence of certain concentrations of glucose, and a cover. In typical embodiments, the substrate layer has elements formed to direct and accumulate sweat that migrates from the skin of the individual to the glucose sensing complex. Methods of using the invention can comprise cleaning the skin surface, collecting sweat in a patch comprising this microfluidic constellation of elements, and observing concentrations of glucose collected in the sweat, for example either visually, or by using a smartphone or other computer processing device.

Nanofiber based sensors are described that can be used to detect analytes in biological or non-biological contexts. Each sensor includes at least two nanofiber yarns that are spaced apart from one another so as to avoid electrical (or physical) contact. Each nanofiber yarn of the nanofiber sensor includes a sensing region that is in electrical contact with the rest of the corresponding nanofiber yarn. The sensing regions of the at least two nanofibers are treated with complementary sensing agents so that when the sensing regions (and the corresponding sensing agents) are exposed to the analyte to be detected, an electrical response is detected. This response is then communicated through one or more of the nanofiber yarns for interpretation by a processor.

Among others, the present invention provides apparatus for interacting with a biological subject to detect circulating tumor cells therein, comprising one device for sending a signal to the biological subject and optionally receiving a response to the signal from the biological entity.