The present disclosure provides systems and methods for the determining a rate of change of one or more analyte concentrations in a target using non invasive non contact imaging techniques such as OCT. Generally, OCT data is acquired and optical information is extracted from OCT scans to quantitatively determine both a flow rate of fluid in the target and a concentration of one or more analytes. Both calculations can provide a means to determine a change in rate of an analyte over time. Example methods and systems of the disclosure may be used in assessing metabolism of a tissue, where oxygen is the analyte detected, or other functional states, and be generally used for the diagnosis, monitoring and treatment of disease.

Systems and methods including a device having integrated sensor arrays constructed and configured to measure and analyze multiple biosignatures concurrently in real time and a mobile application to control the device, process data, and transmit data wirelessly via at least one network to at least one remote computing device for analyzing the multiple biosignatures and cross-correlation with at least one external factor resulting in the creation of personal and situation profiles for continued on-going real time monitoring, refinement, alerting, and action recommendations.

Described here are patches and methods for measuring glucose in sweat (and tears and the like). In general, the patches comprise an adhesive layer adapted to bond to skin of an individual, a substrate layer disposed over the adhesive layer and comprising a glucose sensing complex including a chromogen that changes color in the presence of certain concentrations of glucose, and a cover. In typical embodiments, the substrate layer has elements formed to direct and accumulate sweat that migrates from the skin of the individual to the glucose sensing complex. Methods of using the invention can comprise cleaning the skin surface, collecting sweat in a patch comprising this microfluidic constellation of elements, and observing concentrations of glucose collected in the sweat, for example either visually, or by using a smartphone or other computer processing device.

A wearable paper-based platform with simultaneous passive and active feedback for monitoring perspiration is provided. The sensor platform comprises two modules: a disposable wicking-based sweat collection patch with discrete colorimetric feedback, and a reusable electronic detachable module for active feedback. The disposable patch comprises a hygroscopic wicking material laminated between two polymeric films. The wicking material is patterned with a radial finger design that offers discretized visual readout of the sensor. The active module attaches to the film and alerts the user when the film collects a pre-determined volume of sweat. The multi-feedback system allows high-performance athletes who value objective quantification of perspiration to better assess their sweat loss during physical activities.

An embodiment of the invention provides a method to control a mechanical system based on the cognitive state of a user, where a first action is performed at an input device that is associated with the user. The cognitive state of the user is detected at the input device; and, a change to the first action is determined based on the cognitive state of the user. A controlled action is performed based on the recommended change. A system can include an input device associated with user, where a first action is performed at the input device. A processor connected to the input device detects the cognitive state of the user at the input device and determines a change to the first action based on the cognitive state of the user. A controller connected to the processor performs a controlled action based on the recommended change.

Bodily fluid indicator devices and methods are provided. Such devices and methods can effectively indicate whether the amount of bodily fluid being produced is within a measurable range. In an exemplary embodiment, a bodily fluid indicator device includes a substrate having a surface. Some portions of the surface are covered with a region of absorbent material and other portions of the surface are devoid of the absorbent material. A graduated scale or a reactive feature is printed on the absorbent material. The device is configured to indicate an amount and/or a composition a bodily fluid present on an area of a patient or subject.

Aspects of the present disclosure provide a method for obtaining biological information associated with a user, comprising receiving electrical signals via a first electrode on an ear tip of an earpiece inserted in an ear of the user, receiving electrical signals via a second electrode on an external portion of the earpiece, and deriving an electrocardiogram (ECG) based on the signals received via the first electrode and the second electrode. Aspects also provide a method for determining a pulse travel time (PTT) associated with a user, comprising obtaining a proximal signal using an earpiece inserted in of the user, obtaining a distal signal using the earpiece, and deriving the PTT based on the obtained proximal signal and the obtained distal signal.

A method for quantifying a content of hydrophobic components contained in a liquid using a contact area diffusion factor (CADF) of a droplet of the liquid to a solid surface is provided. In addition, the obtained content of the hydrophobic components provides information about prediction for possibility of developing a metabolic disease or dementia, or information about the incidence or progression of a metabolic disease or dementia.

The disclosed invention provides a biofluid collection device configured with a hexagonal open microfluidic network, which facilitates nanoliter-scale biofluid collection and transport for biosensing applications. In one embodiment, a biofluid sensing device placed on the skin for measuring a characteristic of an analyte in sweat includes one or more biofluid sensors and a hexagonal open microfluidic network biofluid collector. The disclosed collector provides a volume-reduced pathway for sweat biofluid between the one or more sensors and sweat glands when the device is positioned on the skin. In another embodiment, a biofluid collector includes a network of microchannels comprising three or more repeatedly intersecting channels that provide redundant pathways for biofluid transport.

Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.