The invention provides systems for handling biofluids including the transport, capture, collection, storage, sensing, and/or evaluation of biofluids released by tissue. Systems of some aspects provide a versatile platform for characterization of a broad range of physical and/or chemical biofluid attributes in real time and over clinically relevant timeframes. Systems of some aspects provide for collection and/or analysis of biofluids from conformal, watertight tissue interfaces over time intervals allowing for quantitative temporal and/or volumetric characterization of biofluid release, such as release rates and release volumes.

Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system 180 is provided having a first working electrode 150 comprising a first sensor element 102 and a second working electrode 160 comprising a second sensor element 104, and a reference electrode 108 for providing a reference value for measuring the working electrode potential of the sensor elements 102, 104.

A lactic acid measurement device includes a stimulus-responsive gel in the form of a gel which reacts with lactic acid contained in sweat and changes its impedance, an electrical property detection part which detects the impedance of the stimulus-responsive gel, and a concentration estimation part which estimates the concentration of lactic acid contained in sweat from the time-series change in the impedance.

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

A sweat sensor device for sensing at least one analyte includes a plurality of sensors for sensing said at least one analyte and for producing data. Data from a subset of said plurality of sensors is prioritized over data from sensors of said plurality of sensors which are outside said subset. A method of sweat sensing and prioritizing data in a device including a plurality of sensors includes determining a subset of sensors from said plurality of sensors by at least one sensing mechanism that measures a presence of or a property of sweat. The method further includes prioritizing data from a subset of the plurality of sensors over data from sensors of said plurality of sensors that are outside said subset.

A sweat sensing device includes at least one sweat generation unit capable of initiating sudomotor axon reflex (SAR) sweating in an indirect stimulation region and at least one analysis unit capable of sensing a physiological parameter of sweat, collecting a sweat sample, or a combination thereof. The at least one analysis unit is located above the indirect stimulation region when the sweat sensing device is placed on skin.

Various embodiments relate to a method of assisting a user with administering a sweat test based on monitoring one or more physiological conditions of the user by a wearable device. In an embodiment, a wearable device may receive an indication of a selected sweat-test type from the user and determine as a function of the sweat-test type, which of the plurality of physiological sensors to use for data collection. Following data collection, it may be determined on the wearable device, if one or more test-triggering physiological conditions are present in the user. If one or more test-triggering physiological conditions are present, instructions to deploy the sweat-test strip to a location of the user and to start the sweat test may be provided to the user. Instructions may also be provided to the user to end the sweat test.

Disclosed is an apparatus for analyzing the composition of bodily fluid. The apparatus can include a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and a pump unit in operative engagement with the fluid handling network. The pump unit can have an infusion mode, in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode, in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus can include a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample.

Systems and methods of analyzing biological fluid biomarkers, calculating biomarker data, transmitting data to a transceiver device, and storing the data and/or analytics in a database and/or on at least one remote computer server.

A device for receiving and analysing a sample, wherein the analysing involves use of a solution. The device comprises: a sample receiving portion for receiving a sample to be analysed; and a solution capsule having a sealed configuration in which the solution capsule is sealed and a release configuration in which contents of the solution capsule are released via a flow path that provides fluid communication between the solution capsule and the sample receiving portion. The device further comprises a bistable release mechanism comprising an actuator wherein the bistable release mechanism releases only in the event that a force applied to the actuator reaches a threshold force and wherein actuation of the actuator results in one-way conversion of the solution capsule from the sealed configuration into the release configuration.