Systems, devices, methods, and kits for monitoring one or more physiologic and/or physical signals from a subject are disclosed. A system including patches and corresponding modules for wirelessly monitoring physiologic and/or physical signals is disclosed. A service system for managing the collection of physiologic data from a customer is disclosed. An isolating patch for providing a barrier between a handheld monitoring device with a plurality of contact pads and a subject is disclosed.

A smart clothing and backpack system enables a user to perform many actions. The smart clothing includes circuitry and/or is made of a conductive material enclosed in an insulation material. The smart clothing includes a set of sensors configured to detect body information. The smart clothing includes multiple electromagnets configured to adjust a size of the smart clothing. The electromagnets are configured to have an increased attraction to make the smart clothing tighter on the body of the user. The system includes a smart backpack to communicate with the smart clothing. The smart backpack includes a Radio Frequency IDentification (RFID) reader configured to detect RFID tags on or in items within the smart backpack. Many other features are able to be implemented with the smart clothing and backpack system. The smart clothing is able to include a wetsuit configured to communicate with a surfboard and/or a backpack.

According to embodiments of the present invention, a sweat sensing device is provided. The sweat sensing device includes a continuous piece of hydrophilic paper including a first region for receiving sweat, a second region opposite the first region, and a third region therebetween; a flexible hydrophobic film having an opening; and a sensor unit. The hydrophobic film and the hydrophilic paper are arranged adjacent to each other with the opening aligned to and exposing the second region. The sensor unit is configured to facilitate a measurement based on the diffused sweat. The hydrophobic film and the hydrophilic paper are collectively folded in a stacked manner such that the sensor unit is sandwiched between the third and second regions. The hydrophilic paper is adapted for the received sweat to diffuse laterally along the hydrophilic paper. According to further embodiments, a method for forming the sweat sensing device is also provided.

Provided is a method of determining a concentration (C.sub.a) of a first analyte (a) in sweat excreted by a first sweat gland type at a first skin location (i) having the first sweat gland type and a second sweat gland type. The method comprises measuring a first concentration (I) of the first analyte in sweat excreted at the first skin location and measuring at least one parameter of sweat excreted by the second sweat gland type at a second skin location (ii) having the second sweat gland type but not the first sweat gland type. The at least one parameter is used to determine a dilution factor (II) which quantifies dilution of the first analyte by sweat excreted by the second sweat gland type at the first skin location. This dilution factor (II) is then used to correct the first concentration (I) so as to determine the concentration (C.sub.a). Further provided is an apparatus (100) for determining the concentration (C.sub.a).

An enzyme sensor may be configured to measure a measurement target substance included in a secretion of a living body. The enzyme sensor may include a layered structure including, in this order, (a) an absorber layer configured to absorb the secretion, (b) an enzyme layer containing an enzyme, (c) a mediator layer, and (d) an electrode part. The absorber layer may include a polymeric material having a chemically bound crosslinked structure.

In an embodiment, the present disclosure pertains to a wearable sensor. In some embodiments, the wearable sensor includes a double-sided adhesive layer, a paper microfluidic layer, and an encapsulation layer. In an additional embodiment, the present disclosure pertains to a method of biochemical analysis. In general, the method includes collecting biofluid from a subject via a wearable sensor and quantifying the biofluid. In some embodiments, the wearable sensor includes a double-sided adhesive layer and a paper microfluidic layer having a microfluidic channel in a serpentine configuration. In some embodiments the microfluidic channel includes an inlet to receive the biofluid, an outlet to collect the excess biofluid, and a plurality of plasmonic sensors.

An electronic device includes a fingerprint module for at least receiving fingerprint information and a chemical analysis module for analyzing the fingerprint information for chemical features to derive distinguishing characteristics therefrom used for formulating at least one response. The distinguishing characteristics are identified by selecting a number of molecules and/or organic compounds from the fingerprint information analyzed for the chemical features. The distinguishing characteristics include at least age, gender, race, dietary information, and lifestyle information or a combination thereof.

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.

Support structures for positioning sensors on a physiologic tunnel for measuring physical, chemical and biological parameters of the body and to produce an action according to the measured value of the parameters. The support structure includes a sensor fitted on the support structures using a special geometry for acquiring continuous and undisturbed data on the physiology of the body. Signals are transmitted to a remote station by wireless transmission such as by electromagnetic waves, radio waves, infrared, sound and the like or by being reported locally by audio or visual transmission. The physical and chemical parameters include brain function, metabolic function, hydrodynamic function, hydration status, levels of chemical compounds in the blood, and the like. The support structure includes patches, clips, eyeglasses, head mounted gear and the like, containing passive or active sensors positioned at the end of the tunnel with sensing systems positioned on and accessing a physiologic tunnel.