Provided is an apparatus (100) for transporting sweat droplets. The apparatus comprises a plurality of chambers for filling with sweat. Each chamber is defined in a substrate, and has an inlet lying adjacent the surface of the skin. The inlet permits sweat to enter and fill the chamber. Each chamber also has an outlet, delimited by a surface of the substrate, from which a sweat droplet protrudes once the chamber has been filled. The outlets are radially grouped around a central portion (135) of the surface of the substrate to define at least first, second and third groups of chambers. The apparatus further comprises an electrowetting arrangement comprising a plurality of electrodes. Each of the electrodes is electrically chargeable and dischargeable. The electrowetting arrangement comprises at least first, second, and third limbs of electrodes (134, 136, 138) configured to permit transport of the sweat droplets centrally from the first group in the case of the first limb, centrally from the second group in the case of the second limb, and centrally from the third group in the case of the third radial portion by charging and discharging of the electrodes. The electrowetting arrangement also includes a conductive trace arrangement (140A-O; 142A-O) arranged to electrically connect electrodes of the first, second, and third limbs to each other.

Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.

A wearable monitoring system includes a first flexible substrate encapsulating a current ramping system to provide a current to an electrode in direct contact with a predetermined location of skin of a user to promote bodily fluid secretion, and a second flexible substrate placed over the predetermined location, the second flexible substrate having an integrated electrochemical sensor to determine bodily fluid concentration levels secreted through the skin.

Biological detection apparatuses, systems and methods are provided. A biological detection apparatus may include a flexible substrate and a biosensor. The biosensor is provided on the flexible substrate and configured to obtain substance information of a living body.

This disclosure relates generally to a method and system for designing a baseline peptide bioreceptor. State-of-the-art methods provide peptide designing through specific target selection and through desired conformational stability. However, considering individual properties of amino acid while designing a peptide sequence have a greater role in imparting stability in designing the peptide sequence. The disclosed method provides a baseline peptide sequence by identifying active binding sites for a ligand using a computational docking technique. The active sites are selected based on binding affinity of protein-ligand complex. Further, selected binding sites are utilized in identifying energetically favorable interactions of protein-ligand complex through molecular dynamics simulation performed in a biofluid environment. Finally, multi-parameter optimization model with parameters such as sequence length, binding affinity etc. is executed to obtain the baseline peptide.

A sweat sensing device (20) comprises at least one sweat generation unit (22) capable of initiating sudomotor axon reflex (SAR) sweating in an indirect stimulation region and at least one analysis unit (24, 26) capable of sensing a physiological parameter of sweat, collecting a sweat sample, or a combination thereof. The at least one analysis unit (24, 26) is located above the indirect stimulation region when the sweat sensing device is placed on skin.

A body fluid-based biological detection apparatus and method are disclosed, the apparatus including a water filter layer, a molecularly imprinted polymer layer, and a flexible printed circuit board layer in sequence from the bottom to the top, the flexible printed circuit board layer being integrated with a biochemical sensor, where in one state, the water filter layer filters water from a body fluid, and the molecularly imprinted polymer layer recognizes and binds a biomarker in the filtered body fluid, and the binding of the biomarker to the molecularly imprinted polymer layer results in a change in electrical current of the biochemical sensor, so as to convert a biological signal in the body fluid into a physical signal. The present disclosure is a body fluid-based biological detection apparatus and method with high sensitivity and stable detection results.

Described here are embodiments of processes and systems for the continuous manufacturing of implantable continuous analyte sensors. In some embodiments, a method is provided for sequentially advancing an elongated conductive body through a plurality of stations, each configured to treat the elongated conductive body. In some of these embodiments, one or more of the stations is configured to coat the elongated conductive body using a meniscus coating process, whereby a solution formed of a polymer and a solvent is prepared, the solution is continuously circulated to provide a meniscus on a top portion of a vessel holding the solution, and the elongated conductive body is advanced through the meniscus. The method may also comprise the step of removing excess coating material from the elongated conductive body by advancing the elongated conductive body through a die orifice. For example, a provided elongated conductive body 510 is advanced through a pre-coating treatment station 520, through a coating station 530, through a thickness control station 540, through a drying or curing station 550, through a thickness measurement station 560, and through a post-coating treatment station 570.

The technologies described enable tracking statuses of and performance metrics for alcohol sensing devices, with respect to performing device integrity checks in order to ensure that testing of provided samples is performed properly. Systems described include alcohol testing devices including flow tubes, alcohol sensors, pumps, supplementary sensors, processors, and user interfaces. Methods described include steps for performing a set of integrity checks in coordination with receiving samples (e.g., breath samples, transdermal samples, etc.) from users.

Provided is a system for correcting a sweat analyte measurement for temperature. The system comprises a sweat collector (106) for collecting sweat from skin (102). The collected sweat is drawn from the sweat collector to an outlet (110) via a capillary (108). The sweat is drawn through the capillary by capillary action and evaporation of the sweat from the outlet. The evaporation of the sweat from the outlet depends on the temperature. A flow sensor (112) measures a flow rate of the sweat being drawn through the capillary. An analyte sensor (114) obtains the sweat analyte measurement. The system further comprises a controller which is configured to determine a temperature from the measured flow rate. The sweat analyte measurement is then corrected using the determined temperature. Further provided is a method for correcting a temperature-dependent sweat analyte measurement.