In an embodiment an optoelectronic sensor includes a radiation-emitting semiconductor region, a radiation-detecting semiconductor region, a first polarization filter arranged above the radiation-emitting semiconductor region and including a first polarization direction and a second polarization filter arranged above the radiation-detecting semiconductor region and including a second polarization direction, wherein the first polarization direction and the second polarization direction are perpendicular to each other, wherein a radiation-reflecting or radiation-absorbing layer is arranged on side flanks of the radiation-emitting semiconductor region and/or the radiation-detecting semiconductor region and/or the first polarization filter and/or the second polarization filter.

System and method for non-invasive monitoring of physiological measurements of a subject, including at least one monitoring device, to detect changes in measured physiological signals, the monitoring device including at least one measuring unit, wherein each measuring unit includes: at least two light emitting sources, and at least one sensor, to detect light beams emitted from the at least two light emitting source, and a computerized device, in communication with the at least one monitoring device, the computerized device to receive data from monitoring device, wherein the monitoring device is configured to be removably attachable to the subject's body.

An imaging device and method are provided. Light from an object is provided as a plurality of sets of light beams to a phase difference array having a plurality of elements. The phase difference array is configured to provide different optical paths for light included within at least some of a plurality of sets of light beams. The light from the phase difference array is received at an imaging element array. The imaging element array includes a plurality of imaging elements. Information obtained from hyperspectral imaging data based on output signals of the imaging element array can be displayed.

The present invention relates to a system and method for determining at least one vital sign of a subject. To improve the ambient light robustness, said system comprises an illumination unit (2) comprising a plurality of radiation sources (21, 22), which are configured to emit electromagnetic radiation and which are controllable individually or in groups, a control unit (3) configured to control the radiation sources (21, 22) of the illumination unit (2), wherein the control unit (3) is configured to control one or more of the direction, the beam width, and the strength of a radiation beam emitted by a radiation source based on skin region information indicating the location of one or more skin regions of the subject and/or based on vital sign information indicating the quality of the extracted vital sign to illuminate the one or more skin regions of the subject, a detection unit (4) configured to detect high-frequency variations in electromagnetic radiation reflected from the skin region of the subject and to generate a detection signal from the detected high-frequency variations in the electromagnetic radiation, and a vital signs determination unit (5) configured to extract a vital sign from the detection signal.

A glucose sensor comprising an optical energy source having an emitter with an emission pattern; a first polarizer intersecting the emission pattern; a second polarizer spaced a distance from the first polarizer and intersecting the emission pattern, the second polarizer rotated relative to the first polarizer by a first rotational amount Θ; a first optical detector intersecting the emission pattern; a second optical detector positioned proximal to the second polarizer, the first polarizer and the second polarizer being positioned between the optical energy source and the second optical detector, the second optical detector intersecting the emission pattern; a compensating circuit coupled to the second optical detector; and a subtractor circuit coupled to the compensating circuit and the first optical detector.

The present invention relates to a system and method for determining at least one vital sign of a subject. To improve the ambient light robustness, said system comprises an illumination unit (2) configured to illuminate a skin region of the subject, said illumination unit comprising a first radiation source (20) and a second radiation source (21), which are configured to emit differently modulated electromagnetic radiation in two or more wavelength channels and/or in two or more polarization channels, a detection unit (4) configured to detect electromagnetic radiation reflected from the skin region of the subject and to generate detection signals, wherein the detection unit (4) comprises a plurality of detection elements and wherein a detection signal is generated per detection element or group of two or more detection elements, a processing unit (11) configured to demodulate the detection signals corresponding to the modulation applied by the illumination unit to obtain demodulated detection signals, and a vital signs determination unit (5) configured to determine, per wavelength or polarization channel, a statistical measure from said demodulated detection signals at the same instant of time and to extract a vital sign from said statistical measures.

The present invention relates to a wearable device for acquiring physiological information of a subject. To combine the advantages of a contact sensor and a contactless sensor, the wearable device comprises an optical emitter (10) for emitting light into the subject's skin, an optical sensor (20) for receiving light scattered back from the subject's skin in response to the emission of light into the subject's skin, the received light representing or allowing the derivation of physiological information of the subject, and a carrier (30) for being held at the subject's skin and for carrying said emitter (10) and said sensor (20) such that a light receiving area (12), at which the emitted light enters the subject's skin, substantially corresponds to a light reflecting area (22), at which at least part of the scattered light leaves the subject's skin and is received by said optical sensor, the optical sensor (20) is arranged between the optical emitter (10) and the light receiving area (12) and is at least partially transparent for the light emitted by the optical emitter or the optical emitter (10) is arranged between the optical sensor (20) and the light reflecting area (22) and is at least partially transparent for the light reflected from the light reflecting area.

The present invention is a camera with video-rate acquisition and processing for medical imaging applications. In particular, the invention is used to determine the health of a body area by quantitatively measuring blood oxygen levels and melanin content from a real-time video image of a body segment. In certain embodiments, a camera comprises an objective lens; a filter tray located at an aperture stop of the objective lens, wherein the filter tray comprises a plurality of elements, each element passes a spectral band of light; a micro-lens array located at an exit pupil of the objective lens comprising a plurality of micro lenses to form an image plane, wherein the objective lens produces a focused image at the image plane; and a focal plane array comprising a plurality of sensors, wherein each sensor receives light from at least one micro-lens of the micro-lens array.

The present invention relates to a method of identifying or monitoring circulatory failure in a subject, which method comprises assessing the subject's microcirculation in respect of the following parameters: (a) functional capillary density (FCD); (b) heterogeneity of the FCD; (c) capillary flow velocity; (d) heterogeneity of capillary flow velocity; (e) oxygen saturation of microvascular erythrocytes (SmvO.sub.2); and (f) heterogeneity of SmvO.sub.2; wherein parameters (a) to (d) are assessed visually by microscopy and parameters (e) and (f) are assessed by diffuse reflectance spectroscopy (DRS); well as apparatus and software designed for performance of such a method.

Embodiments concern coupling polarized light at two or more wavelengths across the aqueous humor of the eye (e.g., as part of a noninvasive glucose monitoring system). An approach discloses non-contact and minimal contact eye-coupling designs that are part of a system for providing glucose concentration levels via measurements acquired by passing two or more optical beams through the cornea/aqueous chamber in the eye. The approach provides for coupling the light to account for the index mismatch incurred while allowing for monitoring the light polarization. Specifically, in an embodiment the light transitions from the device, through the air, through the proximal side of the cornea, through the aqueous humor, through the medial side of the cornea, and through the air back into the device. Embodiments address the index of refraction mismatch and polarized light maintaining concerns with a coupling approach that can take the form of contact and non-contact mechanisms.