A method for determining a region in which the actual concentration is located, in a medium, of a substrate made up of any molecule likely to undergo catalysed oxidation-reduction by a catalyst. The method includes the following steps: taking at least one group of at least two biosensors, each biosensor having a calibration curve of the signal induced by the oxidation-reduction reaction and having identical initial portions of their calibration curves up to a concentration value of the substrate from which the measurement of the signal differ; and when more than one group is present, the biosensors in different groups having different calibration curves without identical initial portions; placing the biosensors in contact with the medium; measuring the signal induced by the oxidation or reduction reaction for each biosensor in the group/groups; comparing all the signal values produced by the biosensors and following the method described in the description.

Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

Disclosed embodiments include methods and systems including a receiver unit of a glucose monitoring system. The receiver is configured for communicating with a remote transmitter unit coupled with a glucose sensor. The glucose sensor generates data signals associated with a glucose level. The receiver unit includes a processor, a display, and a memory for storing instructions which, when executed by the processor: access a transmitter key associated with the remote transmitter unit; transmit a command to the remote transmitter unit after verifying the transmitter key; receive communication packets from the remote transmitter unit including a first data segment with data signals indicative of the glucose level and a second data segment with information corresponding to a remaining life of the remote transmitter unit; estimate a remaining life of the remote transmitter unit; process the data signals; and output the estimated remaining life and the processed data signals for display.

Disclosed is a method for initializing an analyte measurement system (1, 2, 3), the analyte measurement system (1, 2, 3) being designed for continuous in-vivo measurement of a body fluid analyte concentration. The method including the steps of: a) providing the analyte measurement system (1, 2, 3,) with a control device (3) and a separate skin-mountable patch device (1, 2), the patch device (1, 2) including a disposable unit (1) and an electronics unit (2), the disposable unit (1) including a transcutaneous analyte sensor (10) and machine-readable sensor identifier (121), the electronics unit (2) being configured to releasable couple for an application time period to the disposable unit (1); b) providing a number of stored initialization data sets in a remote database system (4), each stored initialization data set comprising initialization data for an analyte sensor batch; c) reading, via a reading device (31) of the control device (3), the sensor identifier from the disposable unit (1) into the control device (3) and transmitting the sensor identifier to the remote database system; d) determining a matching initialization data set, the matching initialization data set being a stored initialization data set that matches the sensor identifier; e) transmitting the matching initialization data set from the remote database system to the control device (3); f) transmitting the matching initialization data set to the electronics unit (2) and storing the matching initialization data set in a memory (21) of the electronics unit (2).

Embodiments relate to an insertion device that includes: a plunger coupled with a lock collar. The insertion device houses contents including: a striker including self-locking striker snap arm(s) where the striker is kept from firing by a striker spring captured between the plunger and the striker when the insertion device is in a cocked position; a sensor assembly; and a needle carrier that holds a piercing member, the needle carrier captured between the striker and a needle carrier spring where a self-releasing snap(s) keeps the needle carrier cocked, where the plunger prevents the self-releasing snap(s) from repositioning and releasing the needle carrier. The striker fires the needle carrier such that the self-locking striker snap arm(s) are positioned to allow the striker to snap down. The needle carrier is then retracted when the user releases the plunger and the piercing member is encapsulated within the insertion device.

A device includes a multiple analyte sensor, a transimpedance amplifier, and a differential amplifier. The multiple analyte sensor includes a first working electrode, a second working electrode, a counter electrode, and a reference electrode. Each of the first working electrode and the second working electrode is configured to receive a signal indicative of a presence of a respective analyte. The counter electrode is a sum of the received signal of each of the first working electrode and the second working electrode. The transimpedance amplifier is configured to receive a first signal of the received signals from the first working electrode and a second signal of the received signals from the second working electrode. The transimpedance amplifier converts the received first signal and the received second signal to an output including a variable bias offset. The differential amplifier is configured to subtract the variable bias offset from the output.

A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.

Systems configured to perform determining a measurement time period, generating a plurality of clock signals, receiving a plurality of analog signals during the determined measurement time period, the measurement time period establishing a maximum signal resolution associated with the clock and a sigma-delta modulator as a function of analog to digital conversion time to obtain a higher signal resolution, modulating the received plurality of analog signals to generate a frequency data stream over the measurement time period based on the received plurality of analog signals by synchronizing each of the received plurality of analog signals to a corresponding one of the generated plurality of clock signals, and filtering one or more signal artifacts from the frequency data stream over the measurement time period.

Disclosed are devices, systems and methods for in vivo monitoring of localized environment conditions within a patient user by measuring analytes, including glucose, oxygen, and/or other analytes. In some aspects, a sensor device includes a wafer-based substrate, at least one electrochemical sensor two-electrode contingent including a working electrode and a reference electrode on the substrate and configured to detect a target analyte in a body fluid when the sensor device is deployed within a subject's body, where the working electrode is functionalized by a chemical layer configured to facilitate a reaction involving the target analyte that produces an electrical signal; and an electronics unit in communication with the electrochemical sensor electrode contingent to transmit the electrical signal to an external processor.

A remotely actuated pilot valve provides for a pilot gas valve that includes safe lighting and complete shutoff capabilities in the event that the flame that is heating a thermocouple is extinguished, the pilot valve having a pilot flow interrupter to provide pilot gas only when initially opened. A heater system that utilizes such a pilot gas valve is provided as is a method whereby the pilot gas valve used in such a system can be remotely and electronically actuated when required. Remote actuation is accomplished by use of a solenoid that is incorporated within the valve design and which is controlled by a remote operator.