According to an embodiment of the invention, a body fluid sampling device is disclosed. The device includes a channel for allowing passage of the fluid through the channel, a flow controller for maintaining flow of the fluid in the channel; a flow direction controller for changing the direction of the flow of the fluid towards a collection medium; and the flow controller for delivering a portion of the fluid as a sample onto the collection medium.

The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

A method for preparing a bone including percutaneously forming a path to the cancellous bone using a multi-lumen cannula, providing a first passage to the cancellous bone in a central lumen and a second passage in a concentric outer lumen, introducing a rinsing fluid in one of the passages to rinse bone marrow and other soft tissue from the cancellous bone, and removing the rinsed bone marrow from the other passage. Also, a method for percutaneously treating a tissue affected by a lesion, including introducing a rinsing fluid in one of the passages to rinse the lesion and removing the rinsed lesion from the other of the passages. Also, a method of treating tissue with a lesion including introducing a thick flowable material through one lumen of the cannula and applying suction through the other lumen of the cannula.

The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

Provided is a non-invasive blood measuring device comprising: a fixture which in part or in whole is buried in bone tissue of a patient; an abutment provided in a space inside the fixture; a sensing unit including biosensors for measuring a substance in the blood; a filter through which the substance in the blood to be measured is passed through; and an outcall unit.

A method of harvesting bone marrow, including percutaneously introducing a multi-lumen cannula into a cancellous bone, applying suction through a first passage defined in a first lumen of the cannula, injecting a thick flowable material into the bone from a second passage in a second lumen of the cannula, extruding the thick flowable material through a distal end of the cannula into the cancellous bone in order to displace the bone marrow and other bone fluids, the suction applied through the first passage providing a hydraulic force guiding the displaced bone marrow and collecting the displaced bone marrow for a therapeutic or diagnostic purpose. A thick flowable material for use in harvesting bone marrow in the cancellous portion of a bone and a method for percutaneously preparing a bone with a multi-lumen cannula and an inflatable device are also discussed.

The present invention comprises methods and devices for collection of fluids, including cells and cellular materials, from the uterus. A device of the present invention comprises a central tubing member to which, at least, a flexible tubing member and an absorbable member are connected at least at one point. The absorbable member is connected to at least one portion of the central tubing member and to at least one portion of the flexible tubing member. The devices of the present invention are useful in methods of collection of uterine fluids, including blood, cells and cellular material.

The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.