A cartridge is designed to secure and position a waste tube during a blood draw operation. The cartridge includes a T-shaped body with a tubular central portion and one or more gripping flanges. The tubular central portion has an open first end and an elongated cavity elongated cavity that is sized and shaped to receive the waste tube through the open first end. The one or more gripping flanges are attached to a second end of the tubular central portion opposite the first end and extend out away from the tubular central portion in a plane substantially perpendicular to elongated cavity. The cartridge further includes a plunger mechanism affixed to the T-shaped body. The plunger mechanism includes a stem adapted to slide into the cavity through the second end of tubular central portion responsive to an applied external force to eject the waste tube from the cavity through the open first end of the cavity.

An apparatus includes an elongate body including a proximal portion and a distal portion. The elongate body defining a lumen. A set of sensors are disposed on the distal portion of the elongate body. An electrical connector may be coupled to the proximal portion of the elongate body, and is coupled to the set of sensors via an electrical wire extending through the elongate body. A guide member is disposed on the distal portion near the set of sensors, the guide member transitionable between an undeployed configuration and a deployed configuration. The guide member in the deployed configuration is configured to guide movement of the distal portion of the elongate body through a vascular system of a subject using blood flow. The elongate body may have a diameter less than or equal to 8 millimeters (mm).

A dermal patch for collecting a physiological sample includes a housing with a collection chamber, a sample channel and a pin within a receptacle of the housing. The sample channel is configured to direct a physiological sample drawn from a subject to the collection chamber. The pin is removably positioned within the receptacle and is configured to move from an undeployed position to a deployed position. The pin is configured to seal the receptacle when in the undeployed position and is further configured to facilitate generation of negative pressure in the sample channel when the pin is moved from the undeployed to the deployed position.

Disclosed is a syringe apparatus. Syringe apparatus has a barrel including an inner surface, an open end, and an inlet end; a plunger including a plunger head received in slidable sealing contact with the inner surface of the barrel and forming a reservoir therein; and an extensible member, optionally including an additive, is contained in the reservoir. Extensible member can be coupled between the inlet end and the plunger head and is extensible in length L as a bio-liquid (e.g., whole blood) is drawn into the reservoir. Methods of mixing or adding an additive such as an anticoagulant, coagulant, or marker, to a bio-liquid are provided, as are other aspects.

An apparatus includes a housing, a flow control mechanism, and an actuator. At least a portion of the flow control mechanism is movably disposed within the housing. The apparatus further includes an inlet port and an outlet port, and defines a fluid reservoir. The outlet port is fluidically coupled to a second fluid reservoir and is fluidically isolated from the first fluid reservoir. The actuator is configured to move the flow control mechanism between a first configuration, in which the inlet port is placed in fluid communication with the fluid reservoir such that the fluid reservoir receives a first flow of bodily-fluid, and a second configuration, in which the inlet port is placed in fluid communication with the outlet port.

A blood collection apparatus may include a connector, which may include a distal end, a proximal end, and a lumen extending there between. The distal end may include a male luer lock fitting configured to couple to a proximal end of a catheter adapter, and the proximal end may include a male luer slip fitting. The blood collection apparatus may include a lid, which may include a body, a closure, and a tether connecting the body to the closure. The body may include a cover portion and an inner wall extending from the cover portion. The inner wall may be aligned with an aperture extending through the cover portion. The inner wall and the aperture may form a channel configured to receive the male luer slip fitting.

A flow restriction device may include a housing with first and second end portions forming respective first and second openings, and a cavity configured to receive an insert body defining a fluid passage that extends from a first opening of the housing at the first end portion to a second opening of the housing at the second end portion, where the fluid passage extends in more than one direction along a path between the first and second end portions of the housing to induce a resistance to a fluid flow moving through the device, thereby reducing a flow rate and pressure of the fluid, and where the fluid is blood, reduce the hemolysis index of the blood.

A catheter system is provided that includes a catheter and a first catheter adapter having an adapter body and an adapter wing. The catheter body includes distal, proximal and side ports thereon, with the catheter proximal end secured to the distal port and the side port comprising a luer connection. The adapter wing is joined to the adapter body and includes first and second flexible wings configured to be brought into contact with each other when a pinching force is applied thereto. An extension tube is connected to the proximal port and a second catheter adapter is connected to the proximal end of the extension tube. A blood draw device is coupled to the side port and includes a flow tube configured to be advanced distally out from the blood draw device and through the first catheter adapter and into the catheter to perform a blood draw.

A dermal patch device for acquisition and analysis of a physiological sample from a subject can include, a lancet port configured to receive a lancet to pierce the skin of the subject and thereby obtain the physiological sample, a sensor disposed in a sensor chamber, and a plurality of fluid pathways. The dermal patch device can further include a first fluid-filled ampoule, a second fluid-filled ampoule, and a third fluid-filled ampoule. The first fluid-filled ampoule can be actuated to release calibration fluid into the sensor chamber via a first group of the fluid pathways. The second fluid-filled ampoule can be actuated to evacuate the calibration fluid from the sensor chamber via a second group of the fluid pathways among the plurality of fluid pathways. The third fluid-filled ampoule can be actuated to draw the physiological sample into the sensor chamber via a third group of the fluid pathways.

An apparatus includes a housing, a flow control mechanism, and an actuator. At least a portion of the flow control mechanism is movably disposed within the housing. The apparatus further includes an inlet port and an outlet port, and defines a fluid reservoir. The outlet port is fluidically coupled to a second fluid reservoir and is fluidically isolated from the first fluid reservoir. The actuator is configured to move the flow control mechanism between a first configuration, in which the inlet port is placed in fluid communication with the fluid reservoir such that the fluid reservoir receives a first flow of bodily-fluid, and a second configuration, in which the inlet port is placed in fluid communication with the outlet port.