Embodiments of a syringe-based device for procuring bodily fluid samples can include a housing having a port that can be coupled to a lumen-defining device for receiving bodily fluids, an actuator mechanism retained at least partially within the housing, the actuator mechanism including a pre-sample reservoir, a plunger operably coupled with pre-sample reservoir, a plunger cap, a plunger tube, a valve, a plunger seal, an a selectively attachable collection vial for capturing a bodily fluid sample.

Blood sample optimization systems and methods are described that reduce or eliminate contaminates in collected blood samples, which in turn reduces or eliminates false positive readings in blood cultures or other testing of collected blood samples. A blood sample optimization system can include a blood sequestration device located between a patient needle and a sample needle. The blood sequestration device can include a sequestration chamber for sequestering an initial, potentially contaminated aliquot of blood, and may further include a sampling channel that bypasses the sequestration chamber to convey likely uncontaminated blood between the patient needle and the sample needle after the initial aliquot of blood is sequestered in the sequestration chamber.

A biological fluid separation device and a separation process that allows for efficient separation of plasma from a blood sample is disclosed. A biological fluid separation device of the present disclosure is adapted to receive a blood sample having a cellular portion or cells and a plasma portion or plasma. A biological fluid separation device of the present disclosure separates plasma from cells using a track-etched membrane and cross-flow filtration.

Bodily fluid sample collection systems, devices, and method are provided. The sample is collected at a first location and subjected to a first sample processing step. The sample may be shipped to a second location and subjected to a second sample processing step that does not introduce contaminants into a plasma portion of the sample formed from the first processing step. The sample may also be mixed with other material(s) in the collection device.

An independent blood filter device depends on flow geometry to deliver blood serum or plasma free of detrimental levels of hemoglobin. It depends critically on an upstream flow rate or pressure differential limiting control element or device that limits the rate of change of pressure differential across the filter element. Pre-evacuated versions can be used to simultaneously draw blood from a living being and provide pressure differential across the filter element between an evacuated collector and a supply end open to atmosphere. A unit pressurized by hand motion employs the external shape of a partially filled blood collection tube as a piston to produce pressure in advance of the control element or device to create the pressure differential across the filter element to a collector vented to atmosphere. The control element or device is disclosed in numerous forms, including specially sized flow constrictions and compliant arrangements.

A specimen transfer device adapted to receive a blood sample is disclosed. The specimen transfer device includes a housing and an actuation member. A deformable material is disposed within the housing and is deformable from an initial position in which the material is adapted to hold the sample to a deformed position in which at least a portion of the sample is released from the material. A viscoelastic member is disposed within the housing between the material and the housing and between the material and the actuation member. The viscoelastic member is engaged with the actuation member and the material such that movement of the actuation member from a first position to a second position deforms the material from the initial position to the deformed position.

A fluid sample optimization device for optimizing a fluid sample collected by a fluid collection device from a fluid source, where a first portion of the fluid sample potentially has contaminants. The device includes an inlet configured to connect with the fluid source, an outlet configured to connect with the fluid collection device, a sample path connected between the inlet and the outlet, and a contaminant containment reservoir connected between the inlet and the outlet. The contaminant containment reservoir has an air permeable fluid resistor proximate the outlet, and is arranged to receive the first portion of the fluid sample from the fluid source to displace air therein, such that upon receipt of the first portion of the fluid sample and containment of the contaminants in the contaminant containment reservoir, subsequent portions of the fluid sample are conveyed by the sample path from the inlet to the outlet when subsequent pressure differentials are applied between the inlet and the outlet. The fluid sample optimization device can further include a displaceable plug between the inlet and the sample path, that can be displaced by the subsequent pressure differentials to allow the subsequent portions of the fluid to be conveyed through the sample path.

Embodiments in accordance with the present disclosure are directed to sample collecting and dispensing methods and apparatuses. An example apparatus includes a capillary sampler disposed on a device first end, wherein the capillary sampler is configured to collect a fluid sample via an opening and a capillary body. The apparatus further includes a reagents chamber in fluid communication with the capillary sampler, and a barrier assembly disposed between the capillary sampler and the reagents chamber, wherein the barrier assembly is configured to separate fluid in the reagents chamber from the capillary sampler. A plunger assembly disposed on a device second end opposite the device first end, may modify the barrier assembly to dispense the fluid from the reagents chamber to the capillary sampler responsive to application of a force in the direction of the device first end.

An object of the present invention is to provide a blood analysis method and a blood test kit, which are for performing quantitative analysis of components by precisely obtaining a dilution factor. According to the present invention, provided is a blood analysis method including: a step of diluting a collected blood sample with a diluent solution; a step of determining a dilution factor by using a normal value of a normal component which is homeostatically present in blood; and a step of analyzing a concentration of a target component in the blood sample, in which the blood analysis method uses a member selected from the group consisting of a first storing instrument for storing the diluent solution, a collection instrument for collecting the blood, a separation instrument for separating and recovering blood plasma from the blood sample diluted with the diluent solution, a holding instrument for holding the separation instrument, and a second storing instrument for storing the recovered blood plasma, and in which the dilution factor is corrected after calculating in advance an amount of the normal component derived from the diluent solution, and/or an amount of the normal component derived from at least one of the members which may be contained in the diluent solution.

A kit for separating and concentrating body fluid cells is provided. The kit includes a first sealing cap provided with a first close contact body; a first cap connection housing having a first inner connection body in which a first elastic body having a first slit line formed at an end thereof, with which the first close contact body comes into elastic contact when coupled to the first sealing cap, is inserted and disposed in an inner hole so that the first inner connection body is assembled with the first sealing cap; a first housing having one end screw-coupled to the first cap connection housing, and having an inner partition wall formed therein so that a first connection hole corresponding to the inner hole is formed through the inner partition wall; a central housing having one end screw-coupled to the other end of the first housing.