Methods and devices are provided for sample collection and sample separation. In one embodiment, a device is provided for use with a formed component liquid sample, the device comprising at least one sample inlet for receiving said sample; at least a first outlet for outputting only a liquid portion of the formed component liquid sample; at least a second outlet for outputting the formed component liquid sample at least a first material mixed therein.

Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container.

A blood collection tube comprises: 1) a body including a proximal end and a distal end, and defining an axial extent between the proximal end and the distal end; 2) a chamber within the body, the chamber including a plurality of mixing ribs; 3) a vacuum port; and 4) a cap arranged on the proximal end, wherein the cap comprises: a) a top face including a first septum; b) a first conduit having an inlet extending from the first septum and an outlet in fluid communication with the chamber; c) a lateral face including a second septum; d) a second conduit extending radially from the second septum to the first conduit; and a plurality of mixing ribs; wherein, when a fluid source is fluidically connected to the first septum or the second septum, and a vacuum is applied at the vacuum port, the vacuum draws fluid from the fluid source, through the first or second septum, and into the first conduit; and when the tube is rotated around an axis defined by the axial extent, the mixing ribs of the cap and the mixing ribs of the chamber cause fluids therein to swirl, thereby effecting mixing of the fluids therein.