Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.

Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.

Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.

The various embodiments disclosed herein are devices that deliver electrical stimulation and/or vibration stimulation to the surface of skin in proximity to insulin injections and/or glucose testing in order to decrease or eliminate the pain of these procedures.

The various embodiments disclosed herein are devices that deliver electrical stimulation and/or vibration stimulation to the surface of skin in proximity to insulin injections and/or glucose testing in order to decrease or eliminate the pain of these procedures.

A device for monitoring a skin surface for leakage of blood at, for example, a wound or a vascular access. The device comprises a patient unit, a connection unit and a monitor unit. The patient unit comprises a patch, including an adhesive layer to be attached to the skin surface of the patient. The adhesive layer is arranged to attach the patch to the skin so that a predetermined removal force, such as 30N, is required for removing the patch from the skin surface. A patient optical fiber is arranged at the patch and has a proximal end for connection to the connection unit. A patient connector is arranged at the distal end of a connection optical fiber. The connector has an opening passing through the connector, whereby the connection optical fiber is arranged in one end of the opening. The patient optical fiber may be inserted in the other end of the opening so that the proximal end of the patient optical fiber is arranged in register with the distal end of the connection optical fiber in order to transmit light between the optical fibers. A spring is arranged in the connector for exerting a force at the patient optical fiber at a side surface thereof for preventing unintentional withdrawal of the patient optical fiber. However, when the withdrawal force is larger than the removal force of the patch, the patient optical fiber is withdrawn from the connector. Thus, the patch is not removed from the skin even when a large force is exerted on the optical fibers.

Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.

The disclosure relates to a method (100) for notifying a clotting event in an arterial line (1) of a human being (2), to a corresponding system, computer program product and data carrier signal. The method (100) comprises providing (110) a hemodynamic signal indicative of an arterial blood pressure waveform (10) in the arterial line (1); determining (120) a hemodynamic contraction parameter related to a contraction of the heart based on the hemodynamic signal; determining (130) a hemodynamic relaxation parameter related to a relaxation of the heart based on the hemodynamic signal; determining (140) a clotting event in the arterial line (1) in case the hemodynamic contraction parameter indicates a decrease of contractility and the hemodynamic relaxation parameter indicates an increase of contractility, and providing (150) a signal notifying of the determined clotting event.