Blood sample optimization systems and methods are described that reduce or eliminate contaminates in collected blood samples, which in turn reduces or eliminates false positive readings in blood cultures or other testing of collected blood samples. A blood sample optimization system can include a blood sequestration device located between a patient needle and a sample needle. The blood sequestration device can include a sequestration chamber for sequestering an initial, potentially contaminated aliquot of blood, and may further include a sampling channel that bypasses the sequestration chamber to convey likely uncontaminated blood between the patient needle and the sample needle after the initial aliquot of blood is sequestered in the sequestration chamber.

An integrated peripheral intravenous (IV) catheter configured for blood draw both at the time of catheter placement and during catheter indwell. The peripheral IV catheter includes a catheter adapter having a catheter configured to be inserted into a patient's vasculature and a side inlet defining a fluid pathway into and out of the catheter. The peripheral IV catheter also includes a side port member having a main branch, the main branch including a distal end configured to couple the side port member to the side inlet of the catheter adapter and a connector portion accessible via a proximal end of the main branch. Additionally, the peripheral IV catheter includes a blood collection adapter removably and directly coupled to the connector portion of the side port member at the proximal end of the main branch. Furthermore, side pore member of the peripheral IV catheter may include a side branch.

A system for facilitating instrument delivery through a peripheral intravenous catheter may include a catheter adapter having a proximal end, a distal end, and a lumen extending there through. The catheter adapter may include a side port. The system may include an extension tube extending from the side port. The system may include a blood control valve disposed in the lumen of the catheter adapter. The system may include a peripheral intravenous catheter extending distally from the catheter adapter.

A blood collection tube for physically separating the plasma and red blood cell fractions of a centrifuged sample is described. The blood collection tube has an elastomeric sleeve with rigid tube segments at both ends. Following blood collection and centrifugation, the elastomeric sleeve may be twisted to constrict its inner diameter and physically separate the two fractions. The blood collection tube may be secured in this position with a pin and a clamp, and further with an adhesive tape with pH paper. This enables blood samples to be transferred over long distances to a central lab facility without spoiling.

A device (100) having a proximal end (20) and end a distal end (40) for withdrawal of a liquid sample, fractionation, and separation of one or more fractions comprising: a piston assembly (300) comprising a piston (302) dismountably attached at its proximal end (20) to an actuating rod (350); a container (200) having a body (202) disposed with a cylindrical chamber (204) for slidable movement of the piston (302) therein; wherein the cylindrical chamber (204) is provided at the distal end (40) with a resealable septum (410) for co-operation with a puncture needle assembly (600) for withdrawal of the liquid sample, an at the proximal end (20) with a stop member (206), which stop member (206) limits movement of the piston (300) in a proximal direction, wherein the container body (202) is dimensioned to fit inside a centrifuge rotor, and is configured for breakability into two parts at a temperature of 0 deg C. or lower at a breakable zone (210).

An intravenous catheter device may include a guidewire for actively repositioning the catheter tip. A guidewire assembly may be configured to enable a clinician to actively reposition the catheter tip by moving proximal ends of segments of the guidewire. By repositioning the catheter tip, the guidewire assembly may facilitate the collection of a blood sample or the injection of a fluid through the catheter even in instances when the catheter tip has become occluded.

A catheter extension set may include a housing, which may include a distal end, a proximal end, and a lumen. The catheter extension set may include a distal connector coupled to the distal end of the housing and configured to couple to a catheter assembly. The catheter extension set may include a handle, an advancement element, and an instrument. The instrument may extend through a U-shaped channel of the advancement element and may include a fixed first end and a second end. A translation feature may be disposed between the handle and the housing and within a pocket of the advancement element such that in response to distal movement of the handle a first distance, the advancement element moves distally within the lumen the first distance and the second end of the instrument advances distally a second distance. The second distance may be at least twice the first distance.

A catheter extension set may include a housing, which may include a distal end, a proximal end, and a lumen. The catheter extension set may include a distal connector coupled to the distal end of the housing and configured to couple to a catheter assembly. The catheter extension set may include a handle, an advancement element, and an instrument. The instrument may extend through a U-shaped channel of the advancement element and may include a fixed first end and a second end. A translation feature may be disposed between the handle and the housing and within a pocket of the advancement element such that in response to distal movement of the handle a first distance, the advancement element moves distally within the lumen the first distance and the second end of the instrument advances distally a second distance. The second distance may be at least twice the first distance.

A syringe-based device includes a housing, a pre-sample reservoir, and an actuator. The housing defines an inner volume between a substantially open proximal end portion and a distal end portion that includes a port couplable to a lumen-defining device. The pre-sample reservoir is fluidically couplable to the port to receive and isolate a first volume of bodily fluid. The actuator is at least partially disposed in the inner volume and has a proximal end portion that includes an engagement portion and a distal end portion that includes a sealing member. The engagement portion is configured to allow a user to selectively move the actuator between a first configuration such that bodily fluid can flow from the port to the pre-sample reservoir, and a second configuration such that bodily fluid can flow from the port to a sample reservoir defined at least in part by the sealing member and the housing.

A syringe-based device includes a housing, a pre-sample reservoir, and an actuator. The housing defines an inner volume between a substantially open proximal end portion and a distal end portion that includes a port couplable to a lumen-defining device. The pre-sample reservoir is fluidically couplable to the port to receive and isolate a first volume of bodily fluid. The actuator is at least partially disposed in the inner volume and has a proximal end portion that includes an engagement portion and a distal end portion that includes a sealing member. The engagement portion is configured to allow a user to selectively move the actuator between a first configuration such that bodily fluid can flow from the port to the pre-sample reservoir, and a second configuration such that bodily fluid can flow from the port to a sample reservoir defined at least in part by the sealing member and the housing.