A syringe-based device includes a housing, the housing including a port, and an actuator mechanism including a first member and a second member configured to be movably disposed within the housing. The first member includes a syringe body and a plunger movably disposed within the syringe body and including a first plunger seal. The second member includes a second plunger seal defining a channel and a valve fluidically coupled with the channel of the second plunger seal. The device also includes a first fluid reservoir and a second fluid reservoir. The device transitions from a first configuration to a second configuration in which a first type of fluid in the first fluid reservoir is delivered through a port, to a third configuration in which a second type of fluid within the second fluid reservoir is delivered through the port.

A wearable device mounted on a living body can detect an analyte response signal transmitted from tissue in the living body. The tissue contains at particles conjugated to at least one complex of (i) an antibody labeled with a fluorophore, the labeled antibody having a target analyte binding site; and (ii) protein M labeled with a quencher that is complimentary to the fluorophore of the labeled antibody, wherein the labeled protein M competes with the target analytes for the target analyte binding site on the labeled antibody; wherein the fluorophore and quencher are spectrally matched such that there is a detectable change in the fluorescent signal. The analyte response signal is related to interaction of the target analytes with the complexes. A processor can determine a presence or absence of the analytes based on the analyte response signal.

A biopsy needle unit includes a biopsy needle and an elastically deformable safety tube for partially covering the biopsy needle inserted to a lumen extending in a longitudinal direction. A marker is arranged on the biopsy needle at a position protruding from an end portion of the safety tube on an opposite side of a needle tip of the puncture needle when the needle tip portion is accommodated in the lumen. The safety tube has portions in which the lumen is curved at least partially with respect to the longitudinal direction so that the safety tube is elastically deformed due to contact between an inner circumferential face of the lumen and an outer circumferential face of the biopsy needle when the biopsy needle is inserted to the lumen to cause frictional resistance between the inner circumferential face of the lumen and the outer circumferential face of the biopsy needle.

An evacuated container assembly suitable for use in connection with blood collection including: (a) a container member formed of a first polymeric material and having a sidewall and one or more openings; (b) a nanocomposite barrier coating disposed on the container member having a thickness of up to about 30 microns and being derived from an aqueous dispersion including (i) a dispersed barrier matrix polymer; and (ii) a substantially exfoliated silicate filler having an aspect ratio of more than 50; and (c) one or more sealing members disposed in the opening(s) operative to hermetically seal the cavity; wherein the cavity is evacuated and maintains a pressure below atmospheric pressure and exhibits a draw volume loss lower than that of a like assembly without a nanocomposite barrier film by a factor of at least 1.5.

An evacuated container assembly suitable for use in connection with blood collection including: (a) a container member formed of a first polymeric material and having a sidewall and one or more openings; (b) a nanocomposite barrier coating disposed on the container member having a thickness of up to about 30 microns and being derived from an aqueous dispersion including (i) a dispersed barrier matrix polymer; and (ii) a substantially exfoliated silicate filler having an aspect ratio of more than 50; and (c) one or more sealing members disposed in the opening(s) operative to hermetically seal the cavity; wherein the cavity is evacuated and maintains a pressure below atmospheric pressure and exhibits a draw volume loss lower than that of a like assembly without a nanocomposite barrier film by a factor of at least 1.5.

The present invention relates to a device for collecting body fluids including (a) a fluid receiving part including a fluid receiving space in which an internal low pressure less than an external atmospheric pressure is formed; (b) a fluid collection part including a hollow microstructure connected to form an open system with the fluid receiving space of the fluid receiving part; and (c) a microstructure hollow barrier for blocking the hollow of the microstructure to maintain the internal low pressure formed in the fluid receiving means.

A blood collection device to reduce hemolysis in a peripheral intravenous catheter system may include a distal end. The distal end of the blood collection device may include a male luer adapter, which may include a distal opening. The blood collection device may include a cannula in fluid communication with the male luer adapter. The cannula may include a distal end and a sharp proximal tip. The blood collection device may include an elongated neck disposed between the male luer adapter and the sharp proximal tip. The blood collection device may include a fluid pathway extending from the distal opening through the sharp proximal tip. A diameter of the fluid pathway may be constant. An entire length of the fluid pathway is represented by L, and the diameter of the fluid pathway is represented by D. D.sup.4/L may be equal to or less than a predetermined value.

The present invention relates to a method and system for estimating blood analyte levels using a noninvasive optical coherence tomography (OCT) based physiological monitor. An algorithm correlates OCT-based estimated blood analyte data with actual blood analyte data determined by other methods, such as invasively. OCT-based data is fit to the obtained blood analyte measurements to achieve the best correlation. Once the algorithm has generated sets of estimated blood analyte levels, it may refine the number of sets by applying one or more mathematical filters. The OCT-based physiological monitor can be calibrated using an Intensity Difference plot or the Pearson Product Moment Correlation method.

A fluid control device includes an inlet configured to be placed in fluid communication with a bodily fluid source and an outlet configured to be placed in fluid communication with a fluid collection device, which can produce a negative pressure differential between the outlet and the inlet. A sequestration portion is in fluid communication with the inlet and includes a first flow controller configured to transition from a first state to a second state to place the sequestration portion in fluid communication with the outlet when the negative pressure differential has a first magnitude. A sampling portion is in fluid communication with an outlet and includes a second flow controller configured to transition from a first state to a second state to place the sampling portion in fluid communication with the inlet when the negative pressure differential has a second magnitude greater than the first magnitude.

A blood collection tube holder that prevents a blood collection tube from falling even when pressed by an elastic sheath body being compressed is provided. A blood collection tube holder 1 includes a blood collection tube holder body 11 and a holding member 12. The blood collection tube holder body 11 includes a needle tube 17 supported by a needle base 15, and an elastic sheath body 18 covering the needle tube 17, and the holding member 12 includes a press-contact member 22. The blood collection tube holder body 11 includes a tongue-shaped protrusion piece 20.