The pulsed pump magnetometer (PPM) is a new type of magnetometer with much higher dynamic range, linearity, and sensitivity than all other types of magnetometers. These features allow more faithful subtracting and cancelling sources of magnetic noise, enabling high quality biomagnetic measurements. Using an array of PPM sensors enables high quality measurements of biomagnetic signals even in magnetically noisy, real-world conditions like medical offices. Arrays of PPM sensors improve upon pulsed magnetic gradiometers in providing higher sensitivity per sensor and superior noise rejection through noise decorrelation and covariance modeling. Arrays of PPM sensors enable localization and imaging of biomagnetic sources.

The pulsed pump magnetometer (PPM) is a new type of magnetometer with much higher dynamic range, linearity, and sensitivity than all other types of magnetometers. These features allow more faithful subtracting and cancelling sources of magnetic noise, enabling high quality biomagnetic measurements. Using an array of PPM sensors enables high quality measurements of biomagnetic signals even in magnetically noisy, real-world conditions like medical offices. Arrays of PPM sensors improve upon pulsed magnetic gradiometers in providing higher sensitivity per sensor and superior noise rejection through noise decorrelation and covariance modeling. Arrays of PPM sensors enable localization and imaging of biomagnetic sources.

Described herein are methods, software, systems and devices for detecting the presence of an abnormality in an organ, tissue, body, or portion thereof of a subject by analysis of the electromagnetic fields generated by the organ, tissue, body, or portion thereof.

Described herein are methods, software, systems and devices for detecting the presence of an abnormality in an organ, tissue, body, or portion thereof of a subject by analysis of the electromagnetic fields generated by the organ, tissue, body, or portion thereof.

In a magnetic field measurement apparatus, a light source irradiates a gas cell with linearly polarized light serving as pump light and probe light in a Z axis direction, and a magnetic field generator applies, to the gas cell, a magnetic field A.sub.x which is a time function f(t) having the amplitude A.sub.0 taking n fixed values f.sub.i (where i=1, . . . , and n), and a magnetic field A.sub.y which is a time function g(t) having the amplitude A.sub.0 taking m fixed values g.sub.j (where j=1, . . . , and m) in each of X axis and Y axis directions. A calculation controller calculates a magnetic field C (C.sub.x, C.sub.y, C.sub.z) of a measurement region using the X axis and Y axis components A.sub.x and A.sub.y of an artificial magnetic field A, and a spin polarization degree M.sub.x corresponding to a measurement value W.sub.? from a magnetic sensor.

A method of using a magnetometer system (30) to analyse the magnetic field of a region of a subject's body is provided. The method comprises using one or more detectors (60) to detect the time varying magnetic field of a region of a subject's body, using a digitiser (42) to digitise a signal or signals from the one or more detectors (60), each signal that is digitised including noise and a periodic signal produced by one or more of the one or more detectors (60) due to the time varying magnetic field of the region of the subject's body, and averaging the digitised signal or signals over plural periods. The magnetometer system (30) is configured such that the noise in each signal provided to the digitiser for digitisation is greater than about 25% of the interval between digitisation levels of the digitiser (42).

The exemplified technology facilitates de-noising of magnetic field-sensed signal data (e.g., of an electrophysiological event) using signal reconstruction processes that fuse the magnetic field-sensed signal data with another sensed signal data (e.g., voltage gradient signal data) captured simultaneously with the magnetic field-sensed signal data. To this end, the purely algorithmic processing technique beneficially facilitates removal and/or filtering of noise from a sensor lead of a noisy captured source and rebuilds the signal for that lead from information simultaneously obtained from other leads of a different source. In some embodiments, a data are fused via a sparse approximation operation that uses candidate terms based on Van der Pol differential equations.

In a magnetic field measurement apparatus, a light source irradiates a gas cell with linearly polarized light serving as pump light and probe light in a Z axis direction, and a magnetic field generator applies, to the gas cell, a magnetic field A.sub.x which is a time function f(t) having the amplitude A.sub.0 taking n fixed values f.sub.i (where i=1, . . . , and n), and a magnetic field A.sub.y which is a time function g(t) having the amplitude A.sub.0 taking m fixed values g.sub.j (where j=1, . . . , and m) in each of X axis and Y axis directions. A calculation controller calculates a magnetic field C (C.sub.x, C.sub.y, C.sub.z) of a measurement region using the X axis and Y axis components A.sub.x and A.sub.y of an artificial magnetic field A, and a spin polarization degree M.sub.x corresponding to a measurement value W.sub.? from a magnetic sensor.

An organ evaluation device, system, or method is configured to receive electrophysiological data from a patient or model organism and integrates the data in a computational backend environment with anatomical data input from an external source, spanning a plurality of file formats, where the input parameters are combined to visualize and output current density and/or current flow activity having ampere-based units displayed in the spatial context of heart or other organ anatomy.

An organ evaluation device, system, or method is configured to receive electrophysiological data from a patient or model organism and integrates the data in a computational backend environment with anatomical data input from an external source, spanning a plurality of file formats, where the input parameters are combined to visualize and output current density and/or current flow activity having ampere-based units displayed in the spatial context of heart or other organ anatomy.