Abnormalities in electromagnetic fields in the heart, brain, and stomach, among other organs and tissues of the human body, can be indicative of serious health conditions. Described herein are methods, software, systems and devices for detecting the presence of an abnormality in an organ or tissue of a subject by analysis of the electromagnetic fields generated by the organ or tissue.

A computer system receives a plurality of signals corresponding to first time-series magnetic data generated from a plurality of unshielded magnetometers proximate to the human subject. The first time-series magnetic data corresponds to magnetic fields generated from the human subject. The plurality of signals includes contributions from a biomagnetic field from at least a portion of the subject's organ and a background magnetic field. The computer system synchronizes the first time-series magnetic data to a common clock to generate synchronized time-series magnetic data. The computer system applies one or more filters to the synchronized time-series magnetic data to obtain filtered data. The computer system applies one or more noise reduction techniques to the filtered data to generate updated time-series magnetic data.

An apparatus for measuring magnetic fields from a subject's organ comprises a plurality of unshielded magnetometers in a three-dimensional arrangement. A respective pair of magnetometers, in the plurality of magnetometers, has a respective known separation. Each magnetometer in the plurality of magnetometers is configured to simultaneously detect a biomagnetic field from at least a portion of the subject's organ and a background magnetic field and output a signal indicative of the detected biomagnetic field and the background magnetic field.

An apparatus for measuring magnetic fields from a subject's organ comprises a plurality of unshielded magnetometers in a three-dimensional arrangement. A respective pair of magnetometers, in the plurality of magnetometers, has a respective known separation. Each magnetometer in the plurality of magnetometers is configured to simultaneously detect a biomagnetic field from at least a portion of the subject's organ and a background magnetic field and output a signal indicative of the detected biomagnetic field and the background magnetic field.

Devices, systems and methods for monitoring of fetal health through determination of fetal heart rate are described. In an example, beat-to-beat decelerations and accelerations are monitored to estimate fetal position and orientation within the womb using magnetometer sensors. The described embodiments enable long-term monitoring that can be remote from a clinical setting, and is sufficiently portable to be operable while the mother engages in substantial motion during daily activity. An example method includes receiving, from a magnetic sensor, a combined heart signal comprising a mixture of a maternal heart signal and the fetal heart signal, estimating, based on the combined heart signal, one or more parameters associated with a location/motion of the magnetic sensor, generating a de-noised combined heart signal by performing a de-noising operation on the combined heart signal, and tracking, based on the de-noised combined heart signal, an estimate of the fetal heart signal.

Devices, systems and methods for monitoring of fetal health through determination of fetal heart rate are described. In an example, beat-to-beat decelerations and accelerations are monitored to estimate fetal position and orientation within the womb using magnetometer sensors. The described embodiments enable long-term monitoring that can be remote from a clinical setting, and is sufficiently portable to be operable while the mother engages in substantial motion during daily activity. An example method includes receiving, from a magnetic sensor, a combined heart signal comprising a mixture of a maternal heart signal and the fetal heart signal, estimating, based on the combined heart signal, one or more parameters associated with a location/motion of the magnetic sensor, generating a de-noised combined heart signal by performing a de-noising operation on the combined heart signal, and tracking, based on the de-noised combined heart signal, an estimate of the fetal heart signal.

Described is a low voltage, pulsed electrical stimulation device for controlling expression of, for example, follistatin, a muscle formation promotion protein, by tissues. Epicardial stimulation is especially useful for heart treatment. Follistatin controlled release is also useful for treating other ailments, such as erectile dysfunction, aortic aneurysm, and failing heart valves.

Described is a low voltage, pulsed electrical stimulation device for controlling expression of, for example, follistatin, a muscle formation promotion protein, by tissues. Epicardial stimulation is especially useful for heart treatment. Follistatin controlled release is also useful for treating other ailments, such as erectile dysfunction, aortic aneurysm, and failing heart valves.

Provided is a magnetic field measurement device which includes a magnetic sensor array that is composed of a plurality of magnetic sensor cells, each of which has a magnetic sensor and an output unit for outputting an output signal, arranged at lattice points between two curved surfaces, each of which is bent in one direction, so as to be three-dimensionally arranged, and is capable of detecting an input magnetic field in three-axial directions, a measurement data acquisition unit configured to acquire measurement data measured by the magnetic sensor array, and a magnetic field reconstruction unit configured to reconstruct a magnetic field of a component orthogonal to a virtual sensor array plane with respect to one or more positions on the virtual sensor array plane, which is a plane specified in a three-dimensional space, using the measurement data.

An organ evaluation device, system, or method is configured to receive electrophysiological data from a patient or model organism and integrates the data in a computational backend environment with anatomical data input from an external source, spanning a plurality of file formats, where the input parameters are combined to visualize and output current density and/or current flow activity having ampere-based units displayed in the spatial context of heart or other organ anatomy.