Techniques are described for determining cognitive impairment, an example of which includes accessing a set of epochs of magnetoencephalography (MEG) data of responses of a brain of a test patient to a plurality of auditory stimulus events; processing the set of epochs to identify parameter values one or more of which is based on information from the individual epochs without averaging or otherwise collapsing the epoch data. The parameter values are input into a model that is trained based on the parameters to determine whether the test patient is cognitively impaired.

Techniques are described for determining cognitive impairment, an example of which includes accessing a set of epochs of magnetoencephalography (MEG) data of responses of a brain of a test patient to a plurality of auditory stimulus events; processing the set of epochs to identify parameter values one or more of which is based on information from the individual epochs without averaging or otherwise collapsing the epoch data. The parameter values are input into a model that is trained based on the parameters to determine whether the test patient is cognitively impaired.

The present application provides a method and an apparatus of modulating a neuronal firing frequency at a brain functional site in a brain, the method comprising: generating an electromagnetic field with its power in variation at the preset modulating frequency; and arranging the generated electromagnetic field near the brain such that the brain functional site is within the range of the near field of the electromagnetic field, to polarize extracellular fluid at the brain functional site with the power of the electromagnetic field, such that a polarization density of the extracellular fluid varies at the preset modulating frequency and neurons in the extracellular fluid are modulated to fire at the preset modulating frequency.

The present application provides a method and an apparatus of modulating a neuronal firing frequency at a brain functional site in a brain, the method comprising: generating an electromagnetic field with its power in variation at the preset modulating frequency; and arranging the generated electromagnetic field near the brain such that the brain functional site is within the range of the near field of the electromagnetic field, to polarize extracellular fluid at the brain functional site with the power of the electromagnetic field, such that a polarization density of the extracellular fluid varies at the preset modulating frequency and neurons in the extracellular fluid are modulated to fire at the preset modulating frequency.

A biological information measurement system includes a dewar, a single imaging device, and a hardware processor. The dewar covers a head of a subject and contains sensors that are arranged for detecting biological signals. The single imaging device acquires an image in which three or more reference points and the dewar are captured, the reference points being set in relation to the subject. The hardware processor is configured to: measure brain neural activity of the subject based on the biological signals detected by the sensors; determine positional relationships between the reference points of the subject and the sensors based on the reference points and positional relationship data of the dewar; and re-determine the positional relationships between the reference point of the subject and the sensors, based on images that are acquired by the single imaging device at different times.

A biological information measurement system includes a dewar, a single imaging device, and a hardware processor. The dewar covers a head of a subject and contains sensors that are arranged for detecting biological signals. The single imaging device acquires an image in which three or more reference points and the dewar are captured, the reference points being set in relation to the subject. The hardware processor is configured to: measure brain neural activity of the subject based on the biological signals detected by the sensors; determine positional relationships between the reference points of the subject and the sensors based on the reference points and positional relationship data of the dewar; and re-determine the positional relationships between the reference point of the subject and the sensors, based on images that are acquired by the single imaging device at different times.

An information processing device, an information processing method, a recording medium storing a program, and a biomedical-signal measuring system. The information processing device includes circuitry to obtain specific information of a first intensity distribution of a biomedical signal from a source, the specific information being displayed on a display, and extract, based on the specific information, a specified area of the first intensity distribution to obtain second intensity distribution of the biomedical signal to be superimposed on an image indicative of the source. The information processing method includes obtaining specific information of a first intensity distribution of a biomedical signal from a prescribed source, the specific information being displayed on a display, and extracting, based on the specific information, a specified area of the first intensity distribution to obtain second intensity distribution of the biomedical signal to be superimposed on an image indicative of the source.

An information processing device, an information processing method, a recording medium storing a program, and a biomedical-signal measuring system. The information processing device includes circuitry to obtain specific information of a first intensity distribution of a biomedical signal from a source, the specific information being displayed on a display, and extract, based on the specific information, a specified area of the first intensity distribution to obtain second intensity distribution of the biomedical signal to be superimposed on an image indicative of the source. The information processing method includes obtaining specific information of a first intensity distribution of a biomedical signal from a prescribed source, the specific information being displayed on a display, and extracting, based on the specific information, a specified area of the first intensity distribution to obtain second intensity distribution of the biomedical signal to be superimposed on an image indicative of the source.

An array of optically pumped magnetometers includes an array of vapor cells; and an array of beam splitters. The array of beam splitters is arranged into columns, including a first column, and rows. Each row and each column includes at least two of the beam splitters. The array of beam splitters is configured to receive light into the first column of the array and to distribute that light from the first column into each of the rows and to distribute the light from each of the rows into a plurality of individual light beams directed toward the vapor cells.

In one aspect, a computer-implemented method corrects a multi-sphere head model used in dipole localization for a set of magnetic field sensors (MEG sensors) by replacing ghost spheres with replacement spheres that are not ghost spheres. One type of ghost sphere completely encloses the brain volume but is so large that a center of the sphere is outside the brain volume. Another type of ghost sphere lies entirely outside the brain volume. Various approaches for correcting ghost spheres are disclosed.