A radiofrequency detection and acquisition system, which is based on SQUID and configured to be integrated into a nuclear magnetic resonance system, comprises a primary detection antenna, a flux transformer having an inlet winding connected to the primary detection antenna, a low critical temperature SQUID device for capturing the magnetic flux produced by an outlet winding of the flux transformer and supplying a secondary detection signal, a cryogenic device for cooling the SQUID device and the flux transformer, and means for processing the secondary detection signal emitted by the SQUID device to supply an analogue acquisition signal. The primary detection antenna may be of the volume type, comprising Helmholtz coils or saddle coils, or a more complex volume geometry, particularly gradiometric geometry. The means for processing the secondary detection signal may comprise a flux-locked loop, provided to linearize the response of the SQUID device.

A radiofrequency detection and acquisition system, which is based on SQUID and configured to be integrated into a nuclear magnetic resonance system, comprises a primary detection antenna, a flux transformer having an inlet winding connected to the primary detection antenna, a low critical temperature SQUID device for capturing the magnetic flux produced by an outlet winding of the flux transformer and supplying a secondary detection signal, a cryogenic device for cooling the SQUID device and the flux transformer, and means for processing the secondary detection signal emitted by the SQUID device to supply an analogue acquisition signal. The primary detection antenna may be of the volume type, comprising Helmholtz coils or saddle coils, or a more complex volume geometry, particularly gradiometric geometry. The means for processing the secondary detection signal may comprise a flux-locked loop, provided to linearize the response of the SQUID device.

In embodiments, devices, methods and systems to analyze the different mediums of brain function in a mathematically uniform manner may be provided. These devices, methods and systems may manifest at several levels and ways relating to brain physiology, including neuronal activity, molecular chirality and frequency oscillations. For example, in an embodiment, a computer-implemented method for determining structure of living neural tissue may comprise receiving at least one signal from at least one read modality, the signal representing at least one physical condition of the living neural tissue, determining action potentials based on the signals received from the read modalities, determining frequency oscillations based on the signals received from the read modalities and the action potentials, and determining neuron network structures based on the signals received from the read modalities, the action potentials, and the frequency oscillations.

In embodiments, devices, methods and systems to analyze the different mediums of brain function in a mathematically uniform manner may be provided. These devices, methods and systems may manifest at several levels and ways relating to brain physiology, including neuronal activity, molecular chirality and frequency oscillations. For example, in an embodiment, a computer-implemented method for determining structure of living neural tissue may comprise receiving at least one signal from at least one read modality, the signal representing at least one physical condition of the living neural tissue, determining action potentials based on the signals received from the read modalities, determining frequency oscillations based on the signals received from the read modalities and the action potentials, and determining neuron network structures based on the signals received from the read modalities, the action potentials, and the frequency oscillations.

Medical diagnostic devices and related methods of use are described in which one or multiple coils in a sensor, each coil connected with an RLC circuit and frequency counter, are held against a patient's head at predetermined cranial locations. Frequencies of the RLC circuit are measured and compared against those taken from known, control heads, to determine whether there is a medical problem and what type of problem. In some instances, too high of frequencies can reveal pooled blood in the head, a sign of hemorrhagic stroke, while too low of frequencies imply lack of blood supply, a sign of ischemic stroke. A head-mountable frame can assist a first responder in securing and guiding the coils and, along with fiducials, allow for automatic comparison of frequencies with the correct control data.

Medical diagnostic devices and related methods of use are described in which one or multiple coils in a sensor, each coil connected with an RLC circuit and frequency counter, are held against a patient's head at predetermined cranial locations. Frequencies of the RLC circuit are measured and compared against those taken from known, control heads, to determine whether there is a medical problem and what type of problem. In some instances, too high of frequencies can reveal pooled blood in the head, a sign of hemorrhagic stroke, while too low of frequencies imply lack of blood supply, a sign of ischemic stroke. A head-mountable frame can assist a first responder in securing and guiding the coils and, along with fiducials, allow for automatic comparison of frequencies with the correct control data.

A system for electrically stimulating and/or detecting bioelectrical signals of a user comprising: an array of permeable bodies configured to absorb a solution that facilitates electrical coupling with a body region of the user; a housing defining an array of protrusions conforming to the body region and comprising: an array of channels distributed across the array of protrusions, each channel at least partially surrounding a permeable body, configured to deliver the solution to the permeable body, and comprising a barrier that prevents passage of the permeable body past the barrier, and a manifold configured to distribute the solution to the array of channels; and a coupling subsystem comprising a first electrical coupling region in electrical communication with an interior of the manifold, wherein the first electrical coupling region is configured to couple to a second electrical coupling region that couples the first electrical coupling region to the electronics subsystem.

A closed-loop brain computer interface (BCI) system for treating mental or emotional disorders with responsive brain stimulation is disclosed. The system includes an implanted module including a processor configured to process neural data acquired from one or more electrodes in communication with one or more brain regions of a patient. The implanted module is configured to deliver stimulation to electrodes in contact with the brain regions. An interface is in wireless communication with the implanted module and configured to receive the neural data from the implanted module. A controller processes the patient's brain and body signals to provide patient intentional control over the stimulation applied to the one or more electrodes and to control the stimulation.

A brain stimulation apparatus and method making use of electromagnetics in the form of solenoids, in some embodiments, to stimulate brain function during sleep using oscillating low-powered electromagnetic fields to activate select regions of the brain of a subject which interact weakly with said regions, including, in some embodiments, the prefrontal cortex, the hippocampus, visual cortex, and posterior cortical hot zone.

Apparatus for applying Transcranial Magnetic Stimulation (TMS) to a patient comprising a head mount for disposition on the head of a patient, and a plurality of magnet assemblies for releasable mounting on the head mount. The magnet assemblies comprises a magnet for selectively providing a rapidly changing magnetic field capable of inducing weak electric currents for modifying the natural electrical activity of the brain of the patient. The number of magnet assemblies mounted, their individual positioning, and their selective provision of a rapidly changing magnetic field is selected to allow spatial, strength and temporal characteristics of the magnetic field to be tailored for the patient, to provide patient-specific IMS therapy, assist in diagnosis, or map out brain function. The magnet assembles can comprise magnets for provide a rapidly changing magnetic field of at least 500-600 Tesla/second corresponding to a magnet movement speed of no less than 400 Hertz.