Apparatus and methods which enable the stimulation of neurons oriented in all directions within a biological structure using applied magnetic fields.

A system for detecting bioelectrical signals of a user comprising: a set of sensors configured to detect bioelectrical signals from the user, each sensor in the set of sensors configured to provide non-polarizable contact at the body of the user; an electronics subsystem comprising a power module configured to distribute power to the system and a signal processing module configured to receive signals from the set of sensors; a set of sensor interfaces coupling the set of sensors to the electronics subsystem and configured to facilitate noise isolation within the system; and a housing coupled to the electronics subsystem, wherein the housing facilitates coupling of the system to a head region of the user.

The exemplified technology facilitates de-noising of magnetic field-sensed signal data (e.g., of an electrophysiological event) using signal reconstruction processes that fuse the magnetic field-sensed signal data with another sensed signal data (e.g., voltage gradient signal data) captured simultaneously with the magnetic field-sensed signal data. To this end, the purely algorithmic processing technique beneficially facilitates removal and/or filtering of noise from a sensor lead of a noisy captured source and rebuilds the signal for that lead from information simultaneously obtained from other leads of a different source. In some embodiments, a data are fused via a sparse approximation operation that uses candidate terms based on Van der Pol differential equations.

A frequency encoded source imaging system includes an EEG or MEG sensor array and a processing system for analyzing the signals from the sensor array in at least two different frequency bands, where the analysis is localized with respect to a three-dimensional grid corresponding to the portion of the human body. Alternately, a frequency encoded source imaging system includes an EEG or MEG sensor array and a processing system for analyzing the signals from the sensor array in a high-definition frequency band comprising frequencies greater than 70 Hz, where the analysis is localized with respect to a three-dimensional grid corresponding to the portion of the human body

Devices and methods for brain modulation are provided herein. A device may comprise a body and components for activating the brain. Such components include ultrasound transducers. The devices are used to provide ultrasound waves to brain structures in a subject wearing a device for methods to treat traumatic brain injury, affect postural control, affect wakefulness, attention, and alertness, to provide memory control, to alter cerebrovascular hemodynamics, to minimize stress, and to reinforce behavioral actions.

In a magnetic field measurement apparatus, a light source irradiates a gas cell with linearly polarized light serving as pump light and probe light in a Z axis direction, and a magnetic field generator applies, to the gas cell, a magnetic field A.sub.x which is a time function f(t) having the amplitude A.sub.0 taking n fixed values f.sub.i (where i=1, . . . , and n), and a magnetic field A.sub.y which is a time function g(t) having the amplitude A.sub.0 taking m fixed values g.sub.j (where j=1, . . . , and m) in each of X axis and Y axis directions. A calculation controller calculates a magnetic field C (C.sub.x, C.sub.y, C.sub.z) of a measurement region using the X axis and Y axis components A.sub.x and A.sub.y of an artificial magnetic field A, and a spin polarization degree M.sub.x corresponding to a measurement value W.sub.? from a magnetic sensor.

Techniques are described for determining cognitive impairment, an example of which includes accessing a set of epochs of magnetoencephalography (MEG) data of responses of a brain of a test patient to a plurality of auditory stimulus events; processing the set of epochs to identify parameter values one or more of which is based on information from the individual epochs without averaging or otherwise collapsing the epoch data. The parameter values are input into a model that is trained based on the parameters to determine whether the test patient is cognitively impaired.

Exemplary method, system and computer-accessible medium can be provided for diagnosing at least one disease and/or a subtype within a disease. For example, it is possible to determine at least one region of interest, and obtain a plurality of data points associated with each of such region(s) of interest. It is also possible to identify a particular pattern of the data points across each of such region(s) of interest. Further, it is possible, e.g., using a computer arrangement, to determine a likelihood of the disease(s) and/or the subtype by comparing the particular pattern to at least one known pattern.

A device and method is provided for stimulation of neurons. The device includes a stimulation unit that can be implanted into a body of a patient and has stimulation elements that apply a stimulation signal to tissue of the patient to stimulate neurons in the brain and/or the spinal cord of the patient. Moreover, a measuring unit receive a measurement signal that reflects a neuronal activity of the stimulated neurons. Further, a control unit generate a modulation signal from the measurement signal, and modulates an amplitude of a pulse train with the modulation signal. Individual pulses of the pulse train include a first and second pulse portions that introduce and remove charge from the tissue. Moreover, the control unit varies a pause between the pulse portions until the synchronization of the stimulated neurons is minimized or falls below a predetermined threshold.

An information displaying system is configured to display a time axis region and a signal display region on a display device. The time axis region is configured to display a time axis of a biosignal along a first direction and to display a first mark on the time axis, and signal display region is configured to display a plurality of waveforms of the biosignal side by side in a second direction which is different from the first direction. In response to receiving a designation information designating a time, the information displaying system displays, on the signal display region, the plurality of waveforms for a predetermined time range including the time designated by the designation information, and displays a line extending in the second direction at a location of the waveforms corresponding to the first mark.