Three-dimensional electrical source imaging of electrical activity in a biological system (e.g., brain or heart) may involve sensor array recording, at multiple locations, of signals (e.g. electrical or magnetic signals) of electrical activity. An initial estimate of an underlying source is obtained. Edge sparsity is imposed on the estimated electrical activity to eliminate background activity and create clear edges between an active source and background activity. The initial estimate is iteratively reweighted and a series of subsequent optimization problems launched to converge to a more accurate estimation of the underlying source. Images depicting a spatial distribution of a source are generated based on the iteratively reweighted edge sparsity, and the time-course of activity for estimated sources generated. Iterative reweighting penalizes locations with smaller source amplitude based on solutions obtained in previous iterations, and continues until a desirable solution is obtained with clear edges. The objective approach does not require subjective thresholding.

A system for electrically stimulating and/or detecting bioelectrical signals of a user comprising: an array of permeable bodies configured to absorb a solution that facilitates electrical coupling with a body region of the user; a housing defining an array of protrusions conforming to the body region and comprising: an array of channels distributed across the array of protrusions, each channel at least partially surrounding a permeable body, configured to deliver the solution to the permeable body, and comprising a barrier that prevents passage of the permeable body past the barrier, and a manifold configured to distribute the solution to the array of channels; and a coupling subsystem comprising a first electrical coupling region in electrical communication with an interior of the manifold, wherein the first electrical coupling region is configured to couple to a second electrical coupling region that couples the first electrical coupling region to the electronics subsystem.

Techniques and systems are disclosed for implementing multi-core beamforming algorithms. In one aspect, a method of implementing a beamformer technique includes using a spatial filter that contains lead-fields of two simultaneous dipole sources rather than a linear combination of the two to directly compute and obtain optimal source orientations and weights between two highly-correlated sources.

A device for stimulating neurons that includes a stimulation unit that applies mechanically tactile and/or thermal stimuli to the body surface of a patient that stimulate neurons with a pathologically synchronous and oscillatory neural activity. The device includes a measuring unit that records measurement signals of neural activity of the stimulated neurons, and a controller that controls the stimulation unit and analyzes the measurement signals. The controller actuates the stimulation unit to scan at least one part of the body surface of the patient along a path and thereby periodically applies stimuli and also selects two regions or more regions on the patient's body surface along the path where the phase synchronization between the periodic application of the stimuli and the neural activity of the stimulated neurons have a local maximum using the measurement signals. The stimuli are then applied in a delayed manner in the two regions.

A waveform display apparatus includes: a collateral information drawing unit configured to draw collateral information on waveforms with respect to the waveforms in accordance with a predetermined time, the waveforms being acquired by a plurality of sensors and displayed on a screen; a waveform extraction unit configured to extract a characteristic waveform from waveform data; a representative time determination unit configured to determine a representative time of the characteristic waveform extracted by the waveform extraction unit; and a waveform classification unit configured to classify the characteristic waveform extracted by the waveform extraction unit. The collateral information drawing unit is configured to display collateral information corresponding to the representative time of the characteristic waveform in accordance with a classification result by the waveform classification unit, the representative time being determined by the representative time determination unit.

An apparatus for nulling a magnetic field within a nulling region in an external ambient magnetic field comprising a plurality of separate magnetic field generating elements 102 are located at separate respective locations surrounding the nulling region for generating respective nulling magnetic fields extending into the nulling region. A plurality of magnetic field sensing elements 103 are positioned at a plurality of respective separate locations within the nulling region for sensing respective values of the magnetic field within the nulling region. A feedback control unit 150 controls the values of the respective nulling magnetic fields generated by each of the plurality of magnetic field generating elements in response to values of the magnetic field sensed by the plurality of magnetic field sensing elements by driving the magnetic field generating elements with respective electric currents that reduce the magnetic field values detected by respective magnetic field sensing elements to values not exceeding a pre-set threshold value corresponding to a pre-set nulling of the magnetic field within the nulling region.

An apparatus for nulling a magnetic field within a nulling region in an external ambient magnetic field comprising a plurality of separate magnetic field generating elements 102 are located at separate respective locations surrounding the nulling region for generating respective nulling magnetic fields extending into the nulling region. A plurality of magnetic field sensing elements 103 are positioned at a plurality of respective separate locations within the nulling region for sensing respective values of the magnetic field within the nulling region. A feedback control unit 150 controls the values of the respective nulling magnetic fields generated by each of the plurality of magnetic field generating elements in response to values of the magnetic field sensed by the plurality of magnetic field sensing elements by driving the magnetic field generating elements with respective electric currents that reduce the magnetic field values detected by respective magnetic field sensing elements to values not exceeding a pre-set threshold value corresponding to a pre-set nulling of the magnetic field within the nulling region.

A computer system receives a plurality of signals corresponding to first time-series magnetic data generated from a plurality of unshielded magnetometers proximate to the human subject. The first time-series magnetic data corresponds to magnetic fields generated from the human subject. The plurality of signals includes contributions from a biomagnetic field from at least a portion of the subject's organ and a background magnetic field. The computer system synchronizes the first time-series magnetic data to a common clock to generate synchronized time-series magnetic data. The computer system applies one or more filters to the synchronized time-series magnetic data to obtain filtered data. The computer system applies one or more noise reduction techniques to the filtered data to generate updated time-series magnetic data.

A computer system receives a plurality of signals corresponding to first time-series magnetic data generated from a plurality of unshielded magnetometers proximate to the human subject. The first time-series magnetic data corresponds to magnetic fields generated from the human subject. The plurality of signals includes contributions from a biomagnetic field from at least a portion of the subject's organ and a background magnetic field. The computer system synchronizes the first time-series magnetic data to a common clock to generate synchronized time-series magnetic data. The computer system applies one or more filters to the synchronized time-series magnetic data to obtain filtered data. The computer system applies one or more noise reduction techniques to the filtered data to generate updated time-series magnetic data.

A system and a method for spatial positioning of magnetometers. Said system includes: magnetometers, a magnetometer support, first positioning markers, a photogrammetry system, and a controller. The first positioning markers are a non-rotationally-symmetrical pattern. The photogrammetry system includes photographing devices configured to photograph, at at least two of a plurality of photographing sites, first image data of the first positioning markers by means of one or more photographing devices. The controller is configured to receive data of the first image photographed by the photographing devices, calculate spatial positions of the first positioning markers on the basis of pre-obtained system parameters and the first image data, and then calculate spatial positions and spatial orientations of the magnetometers.