Medical diagnostic devices and related methods of use are described in which one or multiple coils in a sensor, each coil connected with an RLC circuit and frequency counter, are held against a patient's head at predetermined cranial locations. Frequencies of the RLC circuit are measured and compared against those taken from known, control heads, to determine whether there is a medical problem and what type of problem. In some instances, too high of frequencies can reveal pooled blood in the head, a sign of hemorrhagic stroke, while too low of frequencies imply lack of blood supply, a sign of ischemic stroke. A head-mountable frame can assist a first responder in securing and guiding the coils and, along with fiducials, allow for automatic comparison of frequencies with the correct control data.

Provided herein are apparatuses, systems and methods for non-invasively assessing synaptic dysfunction in a patient with Alzheimer's Disease. Transcranial magnetic stimulation (TMS) is applied to at least one brain region of the patient. A plurality of TMS evoked potentials generated in response to the TMS applied to the at least one brain region of the patient is recorded with a plurality of electroencephalography (EEG) electrodes. At least one characteristic of the plurality of TMS evoked potentials is analyzed to assess synaptic dysfunction in the patient. An indication of the synaptic dysfunction assessment of the patient is output.

A radiofrequency detection and acquisition system, which is based on SQUID and configured to be integrated into a nuclear magnetic resonance system, comprises a primary detection antenna, a flux transformer having an inlet winding connected to the primary detection antenna, a low critical temperature SQUID device for capturing the magnetic flux produced by an outlet winding of the flux transformer and supplying a secondary detection signal, a cryogenic device for cooling the SQUID device and the flux transformer, and means for processing the secondary detection signal emitted by the SQUID device to supply an analogue acquisition signal. The primary detection antenna may be of the volume type, comprising Helmholtz coils or saddle coils, or a more complex volume geometry, particularly gradiometric geometry. The means for processing the secondary detection signal may comprise a flux-locked loop, provided to linearize the response of the SQUID device.

A radiofrequency detection and acquisition system, which is based on SQUID and configured to be integrated into a nuclear magnetic resonance system, comprises a primary detection antenna, a flux transformer having an inlet winding connected to the primary detection antenna, a low critical temperature SQUID device for capturing the magnetic flux produced by an outlet winding of the flux transformer and supplying a secondary detection signal, a cryogenic device for cooling the SQUID device and the flux transformer, and means for processing the secondary detection signal emitted by the SQUID device to supply an analogue acquisition signal. The primary detection antenna may be of the volume type, comprising Helmholtz coils or saddle coils, or a more complex volume geometry, particularly gradiometric geometry. The means for processing the secondary detection signal may comprise a flux-locked loop, provided to linearize the response of the SQUID device.

Compositions and methods are provided for the detection and/or diagnosis of traumatic brain injury.

Compositions and methods are provided for the detection and/or diagnosis of traumatic brain injury.

A system and method are presented for use in monitoring brain activity of a subject. The system comprises a control unit which comprises: a data input utility for receiving measured data comprising data corresponding to signals measured during a certain time period and being indicative of a subject's brain activity originated from locations in the subject's brain during said certain time period, and a processor utility which is configured and operable for processing the measured data and generating data indicative thereof in the form of a multi-parameter function presenting a relation between frequency and time data of the measured signals and for analyzing said relation and identifying a subject-related signature corresponding to the subject's brain neural activity.

A system and method are presented for use in monitoring brain activity of a subject. The system comprises a control unit which comprises: a data input utility for receiving measured data comprising data corresponding to signals measured during a certain time period and being indicative of a subject's brain activity originated from locations in the subject's brain during said certain time period, and a processor utility which is configured and operable for processing the measured data and generating data indicative thereof in the form of a multi-parameter function presenting a relation between frequency and time data of the measured signals and for analyzing said relation and identifying a subject-related signature corresponding to the subject's brain neural activity.

A frequency encoded source imaging system includes an EEG or MEG sensor array and a processing system for analyzing the signals from the sensor array in at least two different frequency bands, where the analysis is localized with respect to a three-dimensional grid corresponding to the portion of the human body. Alternately, a frequency encoded source imaging system includes an EEG or MEG sensor array and a processing system for analyzing the signals from the sensor array in a high-definition frequency band comprising frequencies greater than 70 Hz, where the analysis is localized with respect to a three-dimensional grid corresponding to the portion of the human body.

A frequency encoded source imaging system includes an EEG or MEG sensor array and a processing system for analyzing the signals from the sensor array in at least two different frequency bands, where the analysis is localized with respect to a three-dimensional grid corresponding to the portion of the human body. Alternately, a frequency encoded source imaging system includes an EEG or MEG sensor array and a processing system for analyzing the signals from the sensor array in a high-definition frequency band comprising frequencies greater than 70 Hz, where the analysis is localized with respect to a three-dimensional grid corresponding to the portion of the human body.