Example implementations include a device with an electrode electrically responsive to presence of a biochemical present within a biofluid, and one or more biofouling and interferent mitigation layers disposed on the electrode to block transmission of biofouling agents to the electrode and the reaction of interferents on the electrode. Example implementations also include a method of obtaining a biofluid sample, mitigating a biofouling characteristic associated with the biofluid sample, and obtaining a biochemical characteristic associated with the biofluid sample.

A system for performing measurements on a biological subject, the system including: at least one substrate including a plurality of plate microstructures configured to breach a stratum corneum of the subject; at least one sensor operatively connected to at least one microstructure, the at least one sensor being configured to measure response signals from the at least one microstructure; and, one or more electronic processing devices configured to: determine measured response signals; and, at least one of: provide an output based on measured response signals; perform an analysis at least in part using the measured response signals; and, store data at least partially indicative of the measured response signals.

The present invention provides a bio-electrode composition including (A) an ionic material and (C) a metal powder, wherein the component (A) is a polymer compound containing a repeating unit-a having a structure selected from the group consisting of an ammonium salt, a sodium salt, a potassium salt, and a silver salt of any of fluorosulfonic acid, fluorosulfonimide, and fluorosulfonamide. This can form a living body contact layer for a bio-electrode that is excellent in electric conductivity and biocompatibility, light-weight, manufacturable at low cost, and free from large lowering of the electric conductivity even though it is wetted with water or dried.

Apparatuses for making electrical connections in electrophysiological measurements and monitoring are disclosed. One such apparatus includes a first side having an electrical contact; a second side opposing the first side and having an electrode disposed over the second side; and a layer disposed between the first side and the second side. The layer is adapted to remove moisture from a region around the electrode. The apparatus also has an electrode line in electrical contact with the electrode disposed over the layer on the first side and extending over the layer on the second side. The electrode line is electrically connected to the electrical contact.

Apparatuses for making electrical connections in electrophysiological measurements and monitoring are disclosed. One such apparatus includes a first side having an electrical contact; a second side opposing the first side and having an electrode disposed over the second side; and a layer disposed between the first side and the second side. The layer is adapted to remove moisture from a region around the electrode. The apparatus also has an electrode line in electrical contact with the electrode disposed over the layer on the first side and extending over the layer on the second side. The electrode line is electrically connected to the electrical contact.

A microelectrode that is useful for implantation into, or placement adjacent, soft tissue, such as neural tissue, and includes a conductive element having a distal non-insulated portion and a proximal insulated portion. Part of the conductive element is disposed in a casing of electrically insulating non-degradable material, the casing encapsulating the non-insulated portion of the conductive element, and including at least one opening and a first structural component in which the electrically insulated portion of the conductive element can slide in an axial direction.

A microelectrode that is useful for implantation into, or placement adjacent, soft tissue, such as neural tissue, and includes a conductive element having a distal non-insulated portion and a proximal insulated portion. Part of the conductive element is disposed in a casing of electrically insulating non-degradable material, the casing encapsulating the non-insulated portion of the conductive element, and including at least one opening and a first structural component in which the electrically insulated portion of the conductive element can slide in an axial direction.

Apparatuses for making electrical connections in electrophysiological measurements and monitoring are disclosed. One such apparatus includes a first side having an electrical contact; a second side opposing the first side and having an electrode disposed over the second side; and a layer disposed between the first side and the second side. The layer is adapted to remove moisture from a region around the electrode. The apparatus also has an electrode line in electrical contact with the electrode disposed over the layer on the first side and extending over the layer on the second side. The electrode line is electrically connected to the electrical contact.

Apparatuses for making electrical connections in electrophysiological measurements and monitoring are disclosed. One such apparatus includes a first side having an electrical contact; a second side opposing the first side and having an electrode disposed over the second side; and a layer disposed between the first side and the second side. The layer is adapted to remove moisture from a region around the electrode. The apparatus also has an electrode line in electrical contact with the electrode disposed over the layer on the first side and extending over the layer on the second side. The electrode line is electrically connected to the electrical contact.

A device for performing electrical measurements for in-ear monitoring is provided. The device includes an in-ear fixture configured to fit in an ear canal of a user, a first electrode mounted on the in-ear fixture and configured to receive an electronic signal from the skin, and an internal microphone to receive an acoustic signal, propagating through the ear of the user. The device also includes an external microphone coupled to receive an external acoustic signal, propagating through an environment, and a processor that is coupled to an augmented reality headset, the processor identifies a cardiovascular condition, or a neurologic condition of the user based on at least one of the electronic signals, the internal acoustic signal, and the external acoustic signal. A memory storing instructions which, when executed by a processor cause a method of use of the above device. The memory, the processor and the method are also provided.