A body worn patient monitoring device includes a flexible substrate having a plurality of electrical connections adapted to be coupled to a skin surface to measure physiological signals. The flexible substrate is adapted to be directly and non-permanently affixed to a skin surface of a patient and configured for single patient use. A communication-computation module, removably attached to an upper surface of the flexible substrate, is configured to receive physiological signals from the flexible substrate and includes a microprocessor that is configured to process and analyze the physiological signals. A series of resistive traces screened onto the flexible substrate are configured as at least one series current-limiting resistor to protect the communication-computation module.

An isolation amplification circuit having an input stage circuitry and a control circuitry stage interconnected through a galvanic isolation barrier. The input stage circuitry includes a first filter network and a second filter network for supplying first and second output signals in response to the application of first and second electrical input signals. The input stage circuitry includes a first feedback path configured for applying a first feedback signal to a common node of the first filter network to close a first feedback loop around the first filter network and a second feedback path configured for applying a second feedback signal to a common node of the second filter network to close a second feedback loop around the second filter network.

Systems, apparatuses, and methods for electroporation ablation therapy are disclosed, with a protection device for protecting electronic circuitry, devices, and/or other components from induced currents and voltages generated during a cardiac ablation procedure. A system can include an ablation device near cardiac tissue of a heart. The system can further include a signal generator configured to generate a pulse waveform, where the signal generator coupled to the ablation device and configured to repeatedly deliver the pulse waveform to the ablation device in synchrony with a set of cardiac cycles of the heart. The system can further include a protection device configured to suppress induced current and voltage in an electronic device coupled to the protection device.

Provided is a physiological information detection sensor capable of implementing miniaturization by substantially securing a creepage distance and an air distance (e.g., implementing defibrillation protection). The physiological information detection sensor includes: a plurality of first substrates arranged in multiple tiers; a second substrate; a first connecting portion that electrically connects adjacent first substrates to each other among the plurality of first substrates; and an insulating member. Each of the plurality of first substrates has a defibrillation protection resistor mounted thereon and electrically connected to a physiological information detection unit. The second substrate has a circuit mounted thereon to process physiological information input from the physiological information detection unit via the defibrillation protection resistor. The insulating member is disposed between adjacent first substrates among the plurality of first substrates.

A computer implemented method and system for declaring arrhythmias in cardiac activity are provided. The method and system are under control of one or more processors that are configured with specific executable instructions. The method and system obtain far field cardiac activity (CA) signals for a series of beats and builds an N-dimensional data set from data values for features of interest from the CA signals. The method and system utilize a manifold structure to map the N-dimensional data set, through nonlinear dimensional reduction, onto an M-dimensional data set and declares an atrial fibrillation (AFL) episode based on a relation between the M-dimensional data set and one or more AFL classification criteria.

A basket-type EP catheter is described. The EP catheter comprises a catheter proximal end that is electrically connected to a controller by an electrical cable having a single voltage-out (Vout) conductor and a catheter distal end supporting a distal connector that is detachably connectable to a basket-shaped configuration of a plurality of splines. Each spline supports an array of electrodes. By sampling the voltage signal on each of the plurality of electrodes sequentially or consecutively, only one Vout conductor is needed to transmit the voltage sample to the controller. In comparison to conventional EP catheters, this greatly reduces the number of conductors extending along the catheter shaft. The use of a Vout conductor is implemented by connecting a polling circuit or a one-shot circuit and a signal pass-transistor or transmission gate to each electrode.

The embodiments include an apparatus used in combination with a computer for sensing biopotentials. The apparatus includes a catheter in which there is a plurality of sensing electrodes, a corresponding plurality of local amplifiers, each coupled to one of the plurality of sensing electrodes, a data, control and power circuit coupled to the plurality of local amplifiers, and a photonic device bidirectionally communicating an electrical signal with the data, control and power circuit. An optical fiber optically communicated with the photonic device. The photonic device bidirectionally communicates an optical signal with the optical fiber. An optical interface device provides optical power to the optical fiber and thence to the photonic device and receives optical signals through the optical fiber from the photonic device. The optical interface device bidirectionally communicates an electrical data, control and power signal to the computer.

The present disclosure facilitates capture of biosignal such as biopotential signals in microvolts, or sub-microvolts, resolutions that are at, or significantly below, the noise-floor of conventional electrocardiographic and biosignal acquisition instruments. In some embodiments, the exemplified system disclosed herein facilitates the acquisition and recording of wide-band phase gradient signals (e.g., wide-band cardiac phase gradient signals, wide-band cerebral phase gradient signals) that are simultaneously sampled, in some embodiments, having a temporal skew less than about 1 s, and in other embodiments, having a temporal skew not more than about 10 femtoseconds. Notably, the exemplified system minimizes non-linear distortions (e.g., those that can be introduced via certain filters) in the acquired wide-band phase gradient signal so as to not affect the information therein.

The present invention provides a circuit applied to a biopotential acquisition system, wherein the circuit includes an active current source and an amplifier. In the operations of the circuit, the active current source is configured to provide a current to two input terminals of the circuit, wherein the two input terminals of the circuit are coupled to two input electrodes of the biopotential acquisition system; and the amplifier is configured to receive input signals from the two input terminals to generate an output signal.

A computer implemented method and system for declaring arrhythmias in cardiac activity are provided. The method and system are under control of one or more processors that are configured with specific executable instructions. The method and system obtain far field cardiac activity (CA) signals for a series of beats and builds an N-dimensional data set from data values for features of interest from the CA signals. The method and system utilize a manifold structure to map the N-dimensional data set, through nonlinear dimensional reduction, onto an M-dimensional data set and declares an atrial fibrillation (AFL) episode based on a relation between the M-dimensional data set and one or more AFL classification criteria.