Disclosed are methods and systems for localizing where in a heart an arrhythmia originates. Electrical data may be recorded using an electrocardiography device, the electrical data corresponding to electrical activity in the heart of a subject. The electrical data (or portions or representations thereof) may be fed to one or more convolutional neural networks. The one or more neural networks may provide an identification of a segment of the heart at which an arrhythmia originates, and whether the arrhythmia has an epicardial or endocardial focus. Arrhythmias may localized and classified non-invasively using only data acquired using, for example, a 12-lead ECG.

A method for acquiring electrical signals from a living subject, including injecting, via an injection electrode attached to the subject, a known calibration signal to the subject and measuring respective levels of output signals generated at input electrodes attached to the subject in response to the calibration signal. The method further includes deriving respective weighting factors for the input electrodes in response to the respective levels, and applying the respective weighting factors to physiological signals acquired by the input electrodes, so as to generate respective corrected physiological signals.

Systems, devices and methods for advanced electrode management in neurological monitoring applications include receiving sockets configured to receive connectors having groups of electrodes. The physician is not required to manually map each electrode with its corresponding input channel. Electrodes are coupled to the corresponding input channels in groups through connectors having a unique identification (ID). The system is configured to read the unique ID of each connector and establish its identity. Based on the ID, the system configures itself to automatically correlate or associate each electrode with its corresponding input channel when the connectors are first inserted into the receiving sockets, and again if the connectors are removed and re-inserted into different positions in the receiving sockets, to insure the electrodes are always mapped to the same input channels.

An example method of analyzing electrocardiogram (ECG) signals includes receiving, at an ECG device, ECG signals from a multi-lead ECG system. The multi-lead ECG system includes multiple electrodes and leads, and each lead of the multi-lead ECG system provides one of the ECG signals and is coupled to more than one of the multiple electrodes, where certain electrodes are coupled to more than one lead. The method also includes detecting artifact in one or more of the ECG signals, classifying the artifact as a type of artifact, determining which leads of the multiple leads contain at least a threshold amount of the type of artifact, for the leads of the multiple leads that contain at least the threshold amount of the type of artifact identifying a common electrode to the leads, and generating a notification by the ECG device indicating that the common electrode is sensing the artifact.

Disclosed herein are methods, systems, and devices for identifying increased likelihood of non-ST elevation myocardial infarction (NSTEMI) in a patient based on ECG data. The methods can include determining based on the ECG data that the patient lacks ST elevation (STE) and that the patient exhibits a ventricular repolarization dispersion (VRD) score that exceeds a predetermined threshold value. The VRD score can be based in part on a T wave complexity ratio that serves as a temporal marker of VRD for the patient. Other markers of spatial and time qualities of repolarization can also be included in the VRD score. An elevated VRD score in the absence of STE can indicate a likelihood of NSTEMI in the patient and a potential major adverse cardiac event.

Long-term electrocardiographic and physiological monitoring over a period lasting up to several years in duration can be provided through a continuously-recording subcutaneous insertable cardiac monitor (ICM). The sensing circuitry and the physical layout of the electrodes are specifically optimized to capture electrical signals from the propagation of low amplitude, relatively low frequency content cardiac action potentials, particularly the P-waves that are generated during atrial activation. The ICM is intended to be implanted centrally and positioned axially and slightly to either the left or right of the sternal midline in the parasternal region of the chest, with at least one of the ECG sensing electrodes of the ICM being disposed for being positioned in a region overlying the sternum or adjacent to the sternum and the other of the electrodes also being disposed for being positioned over the sternum or adjacent to the sternum of on the patient's chest.

A physiological signal monitoring system comprising a pendant and a patch. The pendant includes a data store, a processor, and a cellular modem. The patch includes a cradle and electrodes mechanically and electrically connected with a flexible printed circuit board (PCB). When removably coupled with the cradle of the patch, the pendant receives from the electrodes electrical signals from a patient's heart and either stores the signals to the data store or transmits the signals. A single channel patch configuration includes two electrodes positioned at least 8.0 centimeters (CM) apart. A two channel patch configuration employs three electrodes similarly spaced. Removable auxiliary components may connect to the pendant's device interfaces, each configured to receive physiological input such as electromyogram (EMG), electroencephalogram (EEG), body temperature, heart rate, pedometer, blood pressure, pulse oximetry, respiratory rate, posture/body orientation, and sleep monitoring.

Systems and methods are provided for water resistant connectors. A male connector includes a rib or a draft angle that creates a seal when engaged with a female connector. A male connector includes an overmold that includes or is made of a thermoplastic elastomer. Male or female connectors include molds that include or are made of a thermoplastic polymer, such as polypropylene. A female connector includes spring contacts that fit within individual pockets of the female connector.

Systems and methods are provided for water resistant connectors. A male connector includes a rib or a draft angle that creates a seal when engaged with a female connector. A male connector includes an overmold that includes or is made of a thermoplastic elastomer. Male or female connectors include molds that include or are made of a thermoplastic polymer, such as polypropylene. A female connector includes spring contacts that fit within individual pockets of the female connector.

The present invention provides a medical electrode comprising a conductive metal base comprising a plate element and a boss formed on the plate element and a conductive support cylinder separate from the conductive metal base. The conductive support cylinder is rotatably mounted to the conductive metal base while remaining in electrical communication with said conductive metal base. The present invention also provides a limb clamp for an ECG device. According to the present invention, it is possible to prevent bending of the cable connecting with the medical electrode, thereby avoiding cable failure.