Detecting user contact with one or more electrodes of a physiological signal sensor can be used to ensure physiological signals measured by the physiological signal sensor meet waveform characteristics (e.g., of a clinically accurate physiological signal). In some examples, a mobile and/or wearable device can comprise sensing circuitry, stimulation circuitry, and processing circuitry. The stimulation circuit can drive one or more stimulation signals on one or more electrodes, the resulting signal(s) can be measured (e.g., by the sensing circuitry), and the processing circuitry can determine whether a user is in contact with the electrode(s). Additionally or alternatively, in some examples, mobile and/or wearable device can comprise saturation detection circuitry, and the processing circuitry can determine whether the sensing circuitry is saturated.

An implantable medical device (IMO) includes one or more stimulation engines (SEs) and selectively connectable output switching circuitry for driving a plurality of output nodes associated with a respective plurality of electrodes of the IMO's lead system when implanted in a patient. The output switching circuitry may be configured to facilitate self-test mode (STM) functionality in the IMO (e.g., when it is in a hermetically sealed package) by using a dual mode switch in series with a stimulation engine selection switch with respect to each output node in the output switching circuitry under mode selection control.

Systems and methods are disclosed for local amplification, multiplexing and analog-to-digital conversion of signals sensed from deep brain regions. In one implementation, a system for local amplification, multiplexing and analog-to-digital conversion of signals sensed from deep brain regions comprises a neural probe configured for placement within a brain; at least one signal lead extending from the neural probe; a sensing assembly included on the neural probe including a plurality of electrodes, at least one amplifier configured to generate at least one amplification signal based on the sensed electrical signals generated by the neurons, and at least one multiplexer configured to multiplex at least two amplified signals based on the sensed electrical signals generated by neurons; and an externally located processing assembly with electrical components for analogue to digital conversion of signals, a signal generator, a power source, and electronic circuitry enabling wireless transfer of data and wireless charging of power.

Systems and methods are disclosed for local amplification, multiplexing and analog-to-digital conversion of signals sensed from deep brain regions. In one implementation, a system for local amplification, multiplexing and analog-to-digital conversion of signals sensed from deep brain regions comprises a neural probe configured for placement within a brain; at least one signal lead extending from the neural probe; a sensing assembly included on the neural probe including a plurality of electrodes, at least one amplifier configured to generate at least one amplification signal based on the sensed electrical signals generated by the neurons, and at least one multiplexer configured to multiplex at least two amplified signals based on the sensed electrical signals generated by neurons; and an externally located processing assembly with electrical components for analogue to digital conversion of signals, a signal generator, a power source, and electronic circuitry enabling wireless transfer of data and wireless charging of power.

A system for monitoring a patient includes a first drive electrode configured to be in contact with the patient. The first drive electrode is configured to receive a first electrical current and inject it into the patient. The system also includes a first sense electrode configured to be in contact with the patient. The first sense electrode is configured to sense a first bio-electric signal from the patient. The first bio-electric signal is modified by the first electrical current. The system also includes an impedance circuit connected to the first drive electrode and the first sense electrode. The impedance circuit is configured to measure a bio-impedance or bio-reactance waveform in response to the first bio-electric signal. The system also includes a physiological sensor connected to the first drive electrode and the first sense electrode. The physiological sensor is configured to measure an electrocardiogram waveform based upon the first bio-electric signal.

A system for monitoring a patient includes a first drive electrode configured to be in contact with the patient. The first drive electrode is configured to receive a first electrical current and inject it into the patient. The system also includes a first sense electrode configured to be in contact with the patient. The first sense electrode is configured to sense a first bio-electric signal from the patient. The first bio-electric signal is modified by the first electrical current. The system also includes an impedance circuit connected to the first drive electrode and the first sense electrode. The impedance circuit is configured to measure a bio-impedance or bio-reactance waveform in response to the first bio-electric signal. The system also includes a physiological sensor connected to the first drive electrode and the first sense electrode. The physiological sensor is configured to measure an electrocardiogram waveform based upon the first bio-electric signal.

This disclosure relates to an active medical device which includes a generator for producing multiphase nerve stimulation pulse trains, each pulse train including at least one stimulation pulse preceded by a precharge pulse and ending with a passive discharge pulse. The active medical device also includes a sensor configured to output a control signal representative of a physiological and/or physical parameter capable of being influenced by the output of nerve stimulation pulse trains. The active medical device also includes an automatic charge compensation control circuit configured to receive at the input the control signal output by the sensor, determine an amplitude and/or a precharge pulse time as a function of at least one predetermined criterion, and output to the generator a precharge pulse control signal to be produced at the output.

A signal processing apparatus includes an input voltage selector configured to select an input voltage from a plurality of input voltages; an input element connected to the input voltage selector; and an input current controller configured to control an inflow of an input current in conjunction with an operation of the input voltage selector.

Methods and/or device facilitating and selecting among multiple modes of filtering a cardiac electrical signal, in which one filtering mode includes additional high pass filtering of low frequency signals, relative to the other filtering mode. The selection filtering modes may include comparing sensed signal amplitude to one or more thresholds, using the multiple modes of filtering. In another example, an additional high pass filter is enabled, over and above a default or baseline filtering mode, and the detected cardiac signal is monitored for indications of possible undersensing, and/or for drops in amplitude toward a threshold, and the additional high pass filter may be disabled upon finding of possible undersensing or drop in signal amplitude.

System and apparatus for measuring biopotential and implementation thereof. A device for mitigating electromagnetic interference (EMI) thereby increasing signal-to-noise ratio is disclosed. Specifically, the present disclosure relates to an elegant, novel circuit for measuring a plurality of biopotentials in useful in a variety of medical applications. This allows for robust, portable, low-power, higher S/N devices which have historically required a much bigger footprint.