Neuromuscular monitoring is described that uses a novel lead assembly and a monitor that can select the appropriate electrodes on the lead assembly and calibrate the stimulation signals applied to the patient through the lead assembly. The monitoring can also set a noise floor value to reduce the likelihood of an erroneous train of four ratio.

Neuromuscular monitoring is described that uses a novel lead assembly and a monitor that can select the appropriate electrodes on the lead assembly and calibrate the stimulation signals applied to the patient through the lead assembly. The monitoring can also set a noise floor value to reduce the likelihood of an erroneous train of four ratio.

A body worn patient monitoring device includes a flexible substrate having a plurality of electrical connections adapted to be coupled to a skin surface to measure physiological signals. The flexible substrate is adapted to be directly and non-permanently affixed to a skin surface of a patient and configured for single patient use. A communication-computation module, removably attached to an upper surface of the flexible substrate, is configured to receive physiological signals from the flexible substrate and includes a microprocessor that is configured to process and analyze the physiological signals. A series of resistive traces screened onto the flexible substrate are configured as at least one series current-limiting resistor to protect the communication-computation module.

A device for determining a physiological or psychological state of a mammal is disclosed. The device has at least one earpiece with a main body having a body of revolution with an axis of revolution, and an endpiece configured to be inserted into an ear canal. The endpiece has a cylindrical channel intended to receive a body of revolution for detachably mounting the endpiece on the main body, the endpiece being arranged to be movable in rotation about the axis of revolution in order to allow at least one electrode to be oriented toward a zone of the brain of the mammal, and the endpiece having a plurality of electrodes arranged on an outer surface of the endpiece, each electrode being configured to pick up an electrical signal in the ear canal of the mammal.

A device for determining a physiological or psychological state of a mammal is disclosed. The device has at least one earpiece with a main body having a body of revolution with an axis of revolution, and an endpiece configured to be inserted into an ear canal. The endpiece has a cylindrical channel intended to receive a body of revolution for detachably mounting the endpiece on the main body, the endpiece being arranged to be movable in rotation about the axis of revolution in order to allow at least one electrode to be oriented toward a zone of the brain of the mammal, and the endpiece having a plurality of electrodes arranged on an outer surface of the endpiece, each electrode being configured to pick up an electrical signal in the ear canal of the mammal.

Disclosed herein are apparatuses and methods for treating neurological disorders by electro-stimulation. The apparatus (10) for treating neurological disorders includes at least one electrode (12) implantable in the brain of a patient, and a processing and stimulation device (14) connected to the at least one electrode (12). The processing and stimulation device (14) may include a stimulation module (16) configured to generate a stimulation signal to be sent to the at least one electrode (12), and an acquisition module (20) that measures cerebral activity coming from the brain of the patient. The acquisition module (20) may have a front-end block (27) configured to amplify the potential difference of its input signals (V.sub.1a, V.sub.2a) and to filter a stimulus artifact and may include a multi-stage fully-differential switched capacitor circuit (e.g., an integrated circuit) configured for discrete-time signal processing.

Disclosed herein are apparatuses and methods for treating neurological disorders by electro-stimulation. The apparatus (10) for treating neurological disorders includes at least one electrode (12) implantable in the brain of a patient, and a processing and stimulation device (14) connected to the at least one electrode (12). The processing and stimulation device (14) may include a stimulation module (16) configured to generate a stimulation signal to be sent to the at least one electrode (12), and an acquisition module (20) that measures cerebral activity coming from the brain of the patient. The acquisition module (20) may have a front-end block (27) configured to amplify the potential difference of its input signals (V.sub.1a, V.sub.2a) and to filter a stimulus artifact and may include a multi-stage fully-differential switched capacitor circuit (e.g., an integrated circuit) configured for discrete-time signal processing.

A system for wirelessly obtaining physiological data from a subject includes a sensor patch and a separate electronics package. The sensor patch is disposed on and adheres to the subject, and includes a first part of a releasable electrical connector. An electronics package includes a second part of the first releasable electrical connector, which is used to physically and electrically connect the electronics package to the sensor patch. The electronics package includes a flexible substrate, with shells set on this substrate. The shells enclose the electronics. The shells are connected by a flexible circuit board. Analog front end circuitry is placed in one shell, while the wireless transceiver is placed in the other shell.

A system for wirelessly obtaining physiological data from a subject includes a sensor patch and a separate electronics package. The sensor patch is disposed on and adheres to the subject, and includes a first part of a releasable electrical connector. An electronics package includes a second part of the first releasable electrical connector, which is used to physically and electrically connect the electronics package to the sensor patch. The electronics package includes a flexible substrate, with shells set on this substrate. The shells enclose the electronics. The shells are connected by a flexible circuit board. Analog front end circuitry is placed in one shell, while the wireless transceiver is placed in the other shell.

According to some embodiments, a device for sensing neuromuscular signals is provided. The device may comprise a plurality of signal electrodes aligned along an interior portion of a wearable structure, each signal electrode being configured to detect neuromuscular signals. The device may comprise a plurality of amplifiers, wherein each amplifier includes (i) a first input operatively coupled to a corresponding signal electrode, (ii) an inverting input, and (iii) an output corresponding to a neuromuscular signal channel. The device may comprise one or more buffers configured to tap a voltage at the inverting input of a respective amplifier of the plurality of amplifiers. The device may comprise circuitry configured to operatively couple a plurality of outputs of the plurality of amplifiers to generate a common mode reference signal, wherein the common mode reference signal is provided to the inverting input of one or more amplifiers of the plurality of amplifiers.